Biofilm inhibition in Candida albicans with biogenic hierarchical zinc-oxide nanoparticles

Joshi, Kanchan M.; Shelar, Amruta; Kasabe, Umesh; Nikam, Latesh K.; Pawar, Ramdas A.; Sangshetti, Jaiprakash N.; Kale, Bharat B.; Singh, Ajay Vikram; Patil, Rajendra; Chaskar, Manohar G.

doi:10.1016/j.msec.2021.112592

Cited by 33 publications

(19 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Herein, H & E staining was applied to study the process of wound healing from a histological perspective ( Figure 9 e). The skin tissues in the untreated group and the blank substrate group exhibited acute inflammatory responses and displayed very little sprouting angiogenesis on the 14 days [ 37 ]. The results showed that the wound healing was in a transitional stage between inflammation and regeneration, indicating the infections in the wound were not resolved.…”

Section: Resultsmentioning

confidence: 99%

Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

Guan-ping

Cai

et al. 2022

JFB

View full text Add to dashboard Cite

Antibacterial coating with antibiotics is highly effective in avoiding device-associated infections (DAIs) which is an unsolved healthcare problem that causes significant morbidity and mortality rates. However, bacterial drug resistance caused by uncontrolled release of antibiotics seriously restricts clinical efficacy of antibacterial coating. Hence, a local and controlled-release system which can release antibiotics in response to bacterial infected signals is necessary in antibacterial coating. Herein, a multi-stimulus responsive multilayer antibacterial coating was prepared through layer-by-layer (LbL) self-assembly of montmorillonite (MMT), chlorhexidine acetate (CHA) and Poly(protocatechuic acid-polyethylene glycol 1000-bis(phenylboronic acid carbamoyl) cystamine) (PPPB). The coating can be covered on various substrates such as cellulose acetate membrane, polyacrylonitrile membrane, polyvinyl chloride membrane, and polyurethane membrane, proving it is a versatile coating. Under the stimulation of acids, glucose or dithiothreitol, this coating was able to achieve controlled release of CHA and kill more than 99% of Staphylococcus aureus and Escherichia coli (4 × 108 CFU/mL) within 4 h. In the mouse infection model, CHA releasing of the coating was triggered by infected microenvironment to completely kill bacteria, achieving wounds healing within 14 days.

show abstract

Section: Resultsmentioning

confidence: 99%

Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

Guan-ping

Cai

et al. 2022

JFB

View full text Add to dashboard Cite

show abstract

“…Regarding the antifungal activity, Table 2 revealed that most quinolinequinones exhibited an inversely inhibitory tendency to their antibacterial activity, though weaker than the antibacterial activity. Predominantly, two quinolinequinones ( QQ7 and QQ8 ) showed a profound effect against C. albicans with a MIC value of 4.88 μg/mL, equal to the reference drug clotrimazole [ 34 ]. In addition, when we investigated the inhibitory activity of the same quinolinequinones ( QQ7 and QQ8 ) against C. parapsilosis strains, QQ7 and QQ8 had acceptable activity compared with the reference drug amphotericin B, which had 5-fold and 10-fold less inhibitory potency, respectively.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Relationships between Structure and Antimicrobial Potency of Quinolinequinones

et al. 2022

View full text Add to dashboard Cite

Microorganisms are responsible for hospital infections, and methicillin-resistant Staphylococcus aureus is one of them. In looking for the most effective lead structures to cope with the rise of antimicrobial (antibiotic) resistance, we evaluated the antimicrobial profile of quinolinequinones for potential antimicrobial applications. 1,4-quinone molecules fused with heteroatom have been studied extensively for many years as a source of drugs and lead structures. The aims of this study were to evaluate the antimicrobial activity of quinolinequinones against bacterial and fungal strains, and to probe for potential lead structures. For this reason, the activity of these compounds against three different strains of Candida fungi (C. albicans, C. parapsilosis, and C. tropicalis) and Gram-positive and Gram-negative pathogenic bacteria were investigated, searching for potential lead compounds. Five of nine quinolinequinones showed activity mainly against the Gram-positive strains with a minimal inhibitory concentration within the Clinical and Laboratory Standards Institute (CLSI) levels. The results revealed that quinolinequinones have significant activity against bacteria including Staphylococcus aureus and Staphylococcus epidermidis, and fungi including Candida albicans and Candida parapsilosis. QQ1, QQ2, QQ3, QQ5, and QQ6 exhibited the highest growth inhibition against two essential species of the Gram-positive strains (Staphylococcus epidermidis and Staphylococcus aureus). Among these, four molecules (QQ2, QQ3, QQ5, and QQ6) were also active against Enterococcus faecalis, the other member of the Gram-positive strains. The antifungal profile of two quinolinequinones (QQ7 and QQ8) indicated that they were as effective as the reference drug Clotrimazole against Candida albicans. The same molecules also have potential inhibitory antifungal activity against Candida tropicalis. For better understanding, the most active two quinolinequinones (QQ2 and QQ6) were examined for biofilm inhibition and a time-kill kinetic study.

show abstract

“…and affects the oral cavity, skin, reproductive tract, and gastrointestinal tract [ 1 , 2 , 3 , 4 ]. Candida infections can also occur systemically and lead to life-threatening candidaemia [ 5 , 6 ]. The annual incidence of Candida infections is approximately four million cases worldwide [ 7 ] with a mortality rate about 40% [ 8 , 9 ], resulting in a significant economic burden owing to high drug costs and long hospital stay [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticles to Combat Candida albicans Infections: An Update

et al. 2023

View full text Add to dashboard Cite

Candidiasis is an opportunistic mycosis with high annual incidence worldwide. In these infections, Candida albicans is the chief pathogen owing to its multiple virulence factors. C. albicans infections are usually treated with azoles, polyenes and echinocandins. However, these antifungals may have limitations regarding toxicity, relapse of infections, high cost, and emergence of antifungal resistance. Thus, the development of nanocarrier systems, such as metal nanoparticles, has been widely investigated. Metal nanoparticles are particulate dispersions or solid particles 10–100 nm in size, with unique physical and chemical properties that make them useful in biomedical applications. In this review, we focus on the activity of silver, gold, and iron nanoparticles against C. albicans. We discuss the use of metal nanoparticles as delivery vehicles for antifungal drugs or natural compounds to increase their biocompatibility and effectiveness. Promisingly, most of these nanoparticles exhibit potential antifungal activity through multi-target mechanisms in C. albicans cells and biofilms, which can minimize the emergence of antifungal resistance. The cytotoxicity of metal nanoparticles is a concern, and adjustments in synthesis approaches or coating techniques have been addressed to overcome these limitations, with great emphasis on green synthesis.

show abstract

Biofilm inhibition in Candida albicans with biogenic hierarchical zinc-oxide nanoparticles

Cited by 33 publications

References 72 publications

Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

Multi-Stimulus Responsive Multilayer Coating for Treatment of Device-Associated Infections

Exploring the Relationships between Structure and Antimicrobial Potency of Quinolinequinones

Metal Nanoparticles to Combat Candida albicans Infections: An Update

Contact Info

Product

Resources

About