2020
DOI: 10.3389/fmicb.2020.01455
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Abstract: Histoplasma capsulatum is a dimorphic fungus that causes an important systemic mycosis called histoplasmosis. It is an infectious disease with high prevalence and morbidity that affects the general population. Recently, the ability of these fungi to form biofilms, a phenotype that can induce resistance and enhance virulence, has been described. Despite some efforts, data regarding the impact of nutrients and culture media that affect the H. capsulatum biofilm development … Show more

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Cited by 7 publications
(8 citation statements)
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“…(Sańchez-Vargas et al, 2013;Chandra and Mukherjee, 2015) and Cryptococcus neoformans (Martinez and Casadevall, 2007), our results showed that H. capsulatum exhibits a slower growth as a biofilm structure, similar to those found on Paracoccidioides brasiliensis (Sardi et al, 2015) and Sporothrix schenckii complex (Brilhante et al, 2018) biofilms. Also, EH-315 formed a more robust biofilm compared to G186A, corroborating with the findings of Goncalves et al (2020).…”
Section: Discussionsupporting
confidence: 82%
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“…(Sańchez-Vargas et al, 2013;Chandra and Mukherjee, 2015) and Cryptococcus neoformans (Martinez and Casadevall, 2007), our results showed that H. capsulatum exhibits a slower growth as a biofilm structure, similar to those found on Paracoccidioides brasiliensis (Sardi et al, 2015) and Sporothrix schenckii complex (Brilhante et al, 2018) biofilms. Also, EH-315 formed a more robust biofilm compared to G186A, corroborating with the findings of Goncalves et al (2020).…”
Section: Discussionsupporting
confidence: 82%
“…The biofilm formation was performed as described by Goncalves et al (2020). To test the influence of H. capsulatum Hsp60 in the biofilm development, the protein was blocked through the treatment with the Hsp60 mAb 7B6.…”
Section: Biofilm Developmentmentioning
confidence: 99%
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“…The method applied was a slight modification of the method used in a previous work [ 22 ]. LCEO (from 0.54 to 0.00026 mg/mL and the 0 mg/mL was set as control) was two-fold diluted in TSB and equally mixed with 100 μL A. baumannii TSB suspensions (10 4 CFU/mL) respectively in a 96-well microtiter plate.…”
Section: Methodsmentioning
confidence: 99%