Abstract:Ultra-low molecular weight heparins (ULMWHs) are being used as anticoagulant drugs that exhibit a low risk, long lifetime and high efficacy. However, a robust and cost-effective purification methodology to isolate ULMWHs from naturally occurring heparins (HPs) is lacking. Vaccinia virus envelope protein A27 and a truncated variant (sA27-aa) bind specifically to HPs for virus/cell attachment. Here, we reported that using a high-affinity bioengineered sA27-aa for heparinase depolymerisation enables extraction of… Show more
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