Biodegradation trend of poly(ε-caprolactone) and nanocomposites

Fukushima, Kikku; Abbate, Cristina; Tabuani, D.; Gennari, Mara; Rizzarelli, Paola; Camino, Giovanni

doi:10.1016/j.msec.2010.02.012

Cited by 77 publications

(41 citation statements)

References 28 publications

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“…These drawbacks could be overcome by dispersion of nanoparticles in PCL to prepare nanocomposites that has proven to be suitable for several applications. [5][6][7][8][9][10] In this work PCL/bentonite (PCL/MMT) and PCL/organo-modified bentonite (PCL/OMMT) nanocomposites were processed by melt extrusion followed by injection. Bentonite is natural clay whose main component is the mineral montmorillonite; bentonites are a valuable mineral class for industrial applications because of their high cation exchange capacity and high surface area.…”

Section: -4mentioning

confidence: 99%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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Section: -4mentioning

confidence: 99%

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

et al. 2016

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“…In the antifungal activity test (72 h), we observed that NIS antifungal activity was statistically similar to NIS-NP. This delayed antifungal activity could be related to an enzymatic degradation of PCL nanoparticles by enzymes inside C. albicans (12,44,45). It is well known that some microorganisms such as Fusarium solani (44) and Streptomyces thermoviolaceus subsp.…”

Section: Resultsmentioning

confidence: 99%

“…Several polymers are used to obtain nanostructured reservoirs, standing out the use of the copolymer of lactic-coglycolic acid-acid (PLGA), poly (cyano acrylate) (PCA), and poly-ε-caprolactone (PCL) (11). Under physiological conditions, PCL is degraded by the hydrolysis of ester linkages constituents (12). This degradation mechanism may indicate its potential use in the prepare of nanosystems, which act as reservoir in vaginal mucosa with enhanced mucous penetration in view the preparation of long term implantable devices.…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

et al. 2016

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Abstract. The aim of this work was the development and characterization of nisin-loaded nanoparticles and the evaluation of its potential antifungal activity. Candidiasis is a fungal infection caused by Candida sp. considered as one of the major public health problem currently. The discovery of antifungal agents that present a reduced or null resistance of Candida sp. and the development of more efficient drug release mechanisms are necessary for the improvement of candidiasis treatment. Nisin, a bacteriocin commercially available for more than 50 years, exhibits antibacterial action in food products with potential antifungal activity. Among several alternatives used to modulate antifungal activity of bacteriocins, polymeric nanoparticles have received great attention due to an effective drug release control and reduction of therapeutic dose, besides the minimization of adverse effects by the preferential accumulation in specific tissues. The nisin nanoparticles were prepared by double emulsification and solvent evaporation methods. Nanoparticles were characterized by dynamic light scattering, zeta potential, Fourier transform infrared, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. Antifungal activity was accessed by pour plate method and cell counting using Candida albicans strains. The in vitro release profile and in vitro permeation studies were performed using dialysis bag method and pig vaginal mucosa in Franz diffusion cell, respectively. The results revealed nisin nanoparticles (300 nm) with spherical shape and high loading efficiency (93.88 ± 3.26%). In vitro test results suggest a promising application of these nanosystems as a prophylactic agent in recurrent vulvovaginal candidiasis and other gynecological diseases.

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“…An example of a biodegradable polymer which undergoes microbial degradation, both in contact with living organisms, and in terms of the natural environment is poly(-caprolactone), which can degrade in several biotic environments, including sea, river and lake water, sewage sludge, farm soil and compost [5][6][7][8][9][10][11][12]. According to the literature degradation of poly(-caprolactone) in a living environment can result of simple chemical hydrolysis of ester bonds or from enzymatic attack or both [13].…”

Section: Introductionmentioning

confidence: 99%

Environmental degradability of polycaprolactone under natural conditions

2016

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Abstract. The aim of this work was an estimation of susceptibility of biodegradable poly(-caprolactone) (PCL) to environmental degradation in different natural environments. The commercial poly(-caprolactone) film, the trade name "CAPA 680", was degraded in the compost, pond, open and harbour area of the Baltic Sea. Characteristic parameters of all natural environments were monitored during the incubation of polymer samples and their influence on degradation of PCL was discussed. Susceptibility of PCL to degradation in natural environments was evaluated based on changes of weight, crystallinity and polymer surface morphology. The rate of environmental degradation of PCL depended on the incubation place, environmental conditions and decreased in order: compost>harbour area of the Baltic Sea>open area of the Baltic Sea>pond.

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Biodegradation trend of poly(ε-caprolactone) and nanocomposites

Cited by 77 publications

References 28 publications

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

Hydrolytic and Thermal Degradation of PCL and PCL/Bentonite Compounds

Development and Characterization of Nisin Nanoparticles as Potential Alternative for the Recurrent Vaginal Candidiasis Treatment

Environmental degradability of polycaprolactone under natural conditions

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