Biodegradation of Sodium Diclofenac and Mefenamic Acid: Kinetic studies, identification of metabolites and analysis of enzyme activity

Murshid, Shabnam; Dhakshinamoorthy, Gnana Prakash

doi:10.1016/j.ibiod.2019.104756

Cited by 29 publications

(12 citation statements)

References 58 publications

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Section: Resultsmentioning

confidence: 99%

“…These peaks could be considered degradation products of DFC, suggesting a biodegradation process. According to Murshid and Dhakshinamoorthy, 39 these peaks could be secondary metabolites from cellular enzymatic activity such as hydroxylated forms (phase 1) of the enzyme activity of the cytochrome P450 complex. 40,41 On the other hand, IBU has been characterized as biodegradable, implying a likelihood that a percentage of this has been bio-transformed into metabolites that could not be measured in this study.…”

Section: Pharmaceutical Compounds Removalmentioning

confidence: 99%

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Cell growth and removal capacity of ibuprofen and diclofenac by Parachlorella kessleri at bench scale

Jiménez-Bambague

Florez-Castillo

Gómez-Angulo

et al. 2021

J of Chemical Tech & Biotech

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BACKGROUND The presence of pharmaceutical compounds has been studied in several countries in Latin America, and many xenobiotic compounds have been identified in wastewater, surface water and even drinking water, including ibuprofen and diclofenac. Microalgal‐based systems have been identified as a good alternative for removing these micropollutants, particularly under tropical conditions, and they are associated with low operational cost and high removal efficiency. Although studies for removing pharmaceutical compounds with Parachlorella kessleri are scarce, this microalga has demonstrated good performance in the treatment of wastewater. RESULTS Using doses of ibuprofen of 1000 and 16 000 μg L−1 and of diclofenac of 100 and 500 μg L−1, the removal efficiency of P. kessleri was evaluated under controlled conditions for periods of 12, 48 and 96 h during cell growth. A hormesis process was identified after an alarm phase at the first 12 h and a recovery at 48 h for ibuprofen, because the diclofenac curve achieved an early death phase, which was associated with oxidative damage. Total removal of up to 51.3% and 55.7% was obtained for ibuprofen and diclofenac, respectively. These removal efficiencies were mostly influenced by microalgae by the process of bioaccumulation/adsorption (23.3% for ibuprofen and 37.1% for diclofenac) and by other mechanisms (40.6% for ibuprofen and 44% for diclofenac). CONCLUSION Removal efficiencies were mainly associated with the presence of microalgae and removal mechanisms such as bioaccumulation and biodegradation for diclofenac, and biodegradation for ibuprofen. © 2021 Society of Chemical Industry (SCI).

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Section: Resultsmentioning

confidence: 99%

Section: Pharmaceutical Compounds Removalmentioning

confidence: 99%

Cell growth and removal capacity of ibuprofen and diclofenac by Parachlorella kessleri at bench scale

Jiménez-Bambague

Florez-Castillo

Gómez-Angulo

et al. 2021

J of Chemical Tech & Biotech

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“…However, further increasing the inoculation dose did not improve the average OTC degradation efficiency, which could be due to the depletion of the nutrient sources in the reaction system. 72 The obtained results indicated that no significant difference was observed in the average OTC degradation efficiency with the bacterium BC inoculation doses of 15% and 20% (v/w) within a month's incubation. The inoculation dose was an important indicator to evaluate the practical application of the engineered functional bacteria.…”

Section: Resultsmentioning

confidence: 84%

Bioremediation of tetracycline antibiotics-contaminated soil by bioaugmentation

et al. 2020

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“…In the majority of a few published reports affirming the DCF degradation, the microorganism responsible for the process of degradation has not been identified [42], [43]. A bacterial consortium of Alcaligenes faecelis, Staphylococcus aureus, Staphylococcus haemolyticus and Proteus mirabilis, have been reported to degrade 150 mg L -1 DCF within 120 h with the help of monooxygenase and glucuronidase enzyme [44]. Quintana et al…”

Section: Efficient Dcf Degrading Strainsmentioning

confidence: 99%

Eco-Friendly Remediation to Mitigate the Toxic Effects of Emerging Contaminant Diclofenac

Sharma*,

Setia*

2019

IJRTE

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Diclofenac (DCF), a non-steroidal antiinflammatory drug has turned into an anthropogenic pollutant of emerging concern. Chronic exposure to DCF not only draws special attention to health issues for aquatic organisms, arthropods, and higher plants but also leads to serious damage to human beings. Its persistence in the ecosystem and synergistic interactions with existing pollutants may lead to proliferation of newly emerging contaminants which further disrupt the balance of nature. This comprehensive review highlights the toxicity effects of DCF and its metabolites. To counter this critical environmental imbalance, bioremediation is exploited for effective environmental clean-up. It is a fast, simple, cost effective and eco –friendly approach that explores microbial communities for mitigating the harmful effects of such toxic contaminants to control the levels of pollution. The practice of bioremediation approach using beneficial microorganisms in DCF degradation is important as it generates less hazardous compounds by maintaining the environment stability. Microorganisms adapt in the extreme conditions to transform DCF into innocuous intermediate metabolic products. These beneficial bioremediators can be used in the biological treatment of waste water thereby providing cleaner water resources to reduce the levels of water pollution, which is a great concern worldwide

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Biodegradation of Sodium Diclofenac and Mefenamic Acid: Kinetic studies, identification of metabolites and analysis of enzyme activity

Cited by 29 publications

References 58 publications

Cell growth and removal capacity of ibuprofen and diclofenac by Parachlorella kessleri at bench scale

Cell growth and removal capacity of ibuprofen and diclofenac by Parachlorella kessleri at bench scale

Bioremediation of tetracycline antibiotics-contaminated soil by bioaugmentation

Eco-Friendly Remediation to Mitigate the Toxic Effects of Emerging Contaminant Diclofenac

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