Biodegradation of Silicones (Organosiloxanes)

Łukasiak, Jerzy; Dorosz, Agnieszka; Prokopowicz, Magdalena; Rosciszewski, Pawel; Falkiewicz, Bogdan

doi:10.1002/3527600035.bpol9024

Cited by 18 publications

(23 citation statements)

References 147 publications

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“…4 On the surface of PDMS electrical insulators, that were degraded in outdoor environments, linear molecules with different end groups were formed by ringopening of the cyclic constituents. 5 In addition, linear low-molecular-weight (LMW) compounds already exist in the bulk of the material and migrate to the surface when chain scission occurs (e.g., by discharge). Chain scission results in loss of hydrophobicity (since hydrophilic groups are formed) and the migrating LMW compounds are responsible for the hydrophobic recovery of the surface.…”

Section: Introductionmentioning

confidence: 99%

Degradation of biomedical polydimethylsiloxanes during exposure to in vivo biofilm environment monitored by FE‐SEM, ATR‐FTIR, and MALDI‐TOF MS

Kaali

Momcilovic

Markström

et al. 2009

J of Applied Polymer Sci

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Polymers used for biomedical purposes in medical devices are usually requested to be inert to degradation. This article describes that slow irreversible changes were observed in silicone surfaces exposed to in vivo biofilms even if silicone, in general, is supposed to have excellent long-term properties. Tracheostomy tubes made of silicone rubber were exposed to in vivo biofilm environments in clinical tests for periods of 1, 3, and 6 months. The chemical degradation was monitored by MALDI-TOF MS, ATR-FTIR, and FE-SEM. In addition, the physical changes were monitored by contact angle and hardness measurements. Cyclic polydimethylsiloxane (PDMS) was detected on the surfaces of new (unaged) silicones. On the surfaces of the in vivo samples new compounds, presumably linear methyl-hydroxyl-terminated PDMS, were detected in addition to cyclic PDMS. These compounds may be formed as a result of the hydrolysis of linear dimethyl terminated PDMS, which is also present in the silicone rubber. ATR-FTIR spectroscopy confirmed that hydrolysis had indeed occurred during the in vivo exposure, since SiAOH groups were detected. Furthermore, significant changes in the topography were detected by FE-SEM, indicating the initiation of degradation. No significant changes in the contact angle of the in vivo used samples were observed, but this information may be shielded by the fact that biofilm may remain on the surface, despite the thorough cleaning before the analysis. It is also possible that the surface hydrophobicity was recovered by the diffusion of linear low-molecular-weight compounds from the bulk.

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Section: Introductionmentioning

confidence: 99%

Degradation of biomedical polydimethylsiloxanes during exposure to in vivo biofilm environment monitored by FE‐SEM, ATR‐FTIR, and MALDI‐TOF MS

Kaali

Momcilovic

Markström

et al. 2009

J of Applied Polymer Sci

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“…Finally, the possibility that the unreacted CPMS groups could participate in the biocidal activity should also be considered because it has been shown recently that poly(3‐chloropropylmethylsiloxane) itself is active against bacteria 15…”

Section: Discussionmentioning

confidence: 99%

Electrochemical‐Reduction‐Assisted Assembly of a Polyoxometalate/Graphene Nanocomposite and Its Enhanced Lithium‐Storage Performance

Wang

et al. 2013

Chemistry A European J

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Herein, we present an electrochemically assisted method for the reduction of graphene oxide (GO) and the assembly of polyoxometalate clusters on the reduced GO (rGO) nanosheets for the preparation of nanocomposites. In this method, the Keggin-type H4 SiW12O40 (SiW12) is used as an electrocatalyst. During the reduction process, SiW12 transfers the electrons from the electrode to GO, leading to a deep reduction of GO in which the content of oxygen-containing groups is decreased to around 5%. Meanwhile, the strong adsorption effect between the SiW12 clusters and rGO nanosheets induces the spontaneous assembly of SiW12 on rGO in a uniformly dispersed state, forming a porous, powder-type nanocomposite. More importantly, the nanocomposite shows an enhanced capacity of 275 mAh g(-1) as a cathode active material for lithium storage, which is 1.7 times that of the pure SiW12. This enhancement is attributed to the synergistic effect of the conductive rGO support and the well-dispersed state of the SiW12 clusters, which facilitate the electron transfer and lithium-ion diffusion, respectively. Considering the facile, mild, and environmentally benign features of this method, it is reasonable as a general route for the incorporation of more types of functional polyoxometalates onto graphene matrices; this may allow the creation of nanocomposites for versatile applications, for example, in the fields of catalysis, electronics, and energy storage.

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“…The chain-ends may adsorb an increasing amount of water which can further catalyze the reaction and lead to the complete breakdown of the material. This is the typical degradation mechanism for polyesters, polyamides and polycarbonates, however, the hydrolytic degradation of the stable poly(dimethylsiloxane) may also occur during in vivo use (Kaali et al, 2010a, Lukasiak et al, 2003. Recent long-term studies have confirmed that silicone tracheostomy tubes undergo hydrolytic degradation during use (Kaali et al, 2010a).…”

Section: Degradation Mechanisms Of Medical Polymersmentioning

confidence: 99%

Prevention of Biofilm Associated Infections and Degradation of Polymeric Materials Used in Biomedical Applications

Kaali¹,

Strömberg²,

Karlsson³

2011

Biomedical Engineering, Trends in Materials Science

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Biodegradation of Silicones (Organosiloxanes)

Abstract: Introduction Historical Outline Chemical Structures Occurrence and Functions Properties, Degradation and Biodegradation Degradation and Biodegradation In vitro Biodegradation In vivo … Show more

Cited by 18 publications

References 147 publications

Degradation of biomedical polydimethylsiloxanes during exposure to in vivo biofilm environment monitored by FE‐SEM, ATR‐FTIR, and MALDI‐TOF MS

Degradation of biomedical polydimethylsiloxanes during exposure to in vivo biofilm environment monitored by FE‐SEM, ATR‐FTIR, and MALDI‐TOF MS

Electrochemical‐Reduction‐Assisted Assembly of a Polyoxometalate/Graphene Nanocomposite and Its Enhanced Lithium‐Storage Performance

Prevention of Biofilm Associated Infections and Degradation of Polymeric Materials Used in Biomedical Applications

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