Biodegradable Synthetic Antimicrobial with Aggregation-Induced Emissive Luminogens for Temporal Antibacterial Activity and Facile Bacteria Detection

Abstract

Aiming to address the antimicrobial resistance and environmental burdens because of the widespread indulgence in biocides, a synthetic formula of biocides with controllable antibacterial activities and biodegradable characters are encouraged for the emergence of a novel spectrum of green biocides. In this respect, a polymeric antimicrobial catiomer, with the polymeric backbone sequentially attached with the functional cationic moieties and lipophilic moieties is synthesized. The striking antibacterial potency is achieved for treatment of both amoxicillin (AMO)-resistant Gram-positive S. aureus and Gram-negative E. coli. Moreover, the anionic aggregation-induced emission (AIE) compound is strategically introduced into the aforementioned polymeric antibacterial system, consequently employed as a facile reporter for the utility of bacteria detection based on the electrostatic reaction of anionic species in the bacterial membrane with the cationic polymeric antibacterials to liberate the anionic AIE compound. Ultimately, the proposed system is determined to afford appreciable temporal antibacterial potency by virtue of the readily available cleavage of the ester linkage in the presence of lipase, thereby eliminating the possibility of the antimicrobial resistance and environmental burdens. Hence, the proposed system provided a bottom-up approach for construction of an intriguing green antibacterial molecule.

Polymer Brush Decorated MOF Nanoparticles Loaded with AIEgen, Anticancer Drug, and Supramolecular Glue for Regulating and In Situ Observing DOX Release

“…And the amount of PGEDA in the UiO‐PGEDA was calculated to be approximately 81 wt% post polymer‐modification using thermogravimetric analysis. On the other hand, the synthetic scheme for preparation of carboxyl‐functionalized TPE was depicted in Scheme S2, Supporting Information, and the synthetic procedures were followed by our previously reported protocol . The protons of the anticipated structures were also verified in good agreement with the corresponding 1 H NMR spectra, suggesting the successful synthesis of TPE‐(COOH) 4 (Figure S2, Supporting Information).…”

Highly-branched poly(N-isopropyl acrylamide) functionalised with pendant Nile red and chain end vancomycin for the detection of Gram-positive bacteria

“…Also, we provided evidence to show that equivalent linear polymer did not aggregate the bacteria despite being shown to bind the target D-alanyl-D-alanyl (D-Ala-D-Ala) [14] , [15] , [16] . Recently, Chen et al reported a bactericidal branched cationic polymer [17] . The central hypothesis developed on the action of these polymers has been that ligands placed at the chain ends of a highly branched polymer are available for binding to cellular targets in both the open-coil solvated form and the desolvated globular form.…”

Antimicrobial Activity of Hybrid Nanomaterials Based on Star and Linear Polymers of N,N′-Dimethylaminoethyl Methacrylate with In Situ Produced Silver Nanoparticles

“…Poly( N , N ′-(dimethylamino)ethyl methacrylate) (PDMAEMA) is a good cationic polymer for stabilizing AgNPs and exhibits biocidal properties by itself [ 10 , 11 , 12 ]. Functional amine groups of these polymers are often additionally quaternized to enhance their bactericidal activity [ 11 , 13 , 14 , 15 ] because they are capable of interacting with negatively charged bacterial cell surface structures. Alkyl halides are most commonly used for the quaternization reaction [ 11 , 12 ].…”