Biodegradable Shape‐Memory Polymers

Behl, Marc; Zotzmann, J.; Schroeter, Michael; Lendlein, Andreas

doi:10.1002/9783527635818.ch8

Cited by 5 publications

(9 citation statements)

References 80 publications

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“…reports biodegradable SMPs developed in the four primary SMP network structure categories of covalently crosslinked crystalline and amorphous networks, and physically crosslinked crystalline and amorphous networks. [32] Multiple PCL based physically and covalently crosslinked crystalline biodegradable polymers have also been reported. [32] Particularly, covalently crosslinked amorphous biodegradable SMP networks, as proposed in this work, have been reported from coupling star-shaped hydroxyl- telechelic polyesters with a diisocyanate.…”

Section: Discussionmentioning

confidence: 99%

“…[32] Multiple PCL based physically and covalently crosslinked crystalline biodegradable polymers have also been reported. [32] Particularly, covalently crosslinked amorphous biodegradable SMP networks, as proposed in this work, have been reported from coupling star-shaped hydroxyl- telechelic polyesters with a diisocyanate. [33] In this polymeric system, star shaped precursors were developed from reaction of polyfunctional initiators such as 1, 1, 1 - tris(hydroxymethyl)ethane, and pentaerythrite with copolyester segments from diglycolide or other cyclic diesters, and dilactide.…”

Section: Discussionmentioning

confidence: 99%

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Low density biodegradable shape memory polyurethane foams for embolic biomedical applications

et al. 2014

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Low density shape memory polymer foams hold significant interest in the biomaterials community for their potential use in minimally invasive embolic biomedical applications. The unique shape memory behavior of these foams allows them to be compressed to a miniaturized form, which can be delivered to an anatomical site via a transcatheter process, and thereafter actuated to embolize the desired area. Previous work in this field has described the use of a highly covalently crosslinked polymer structure for maintaining excellent mechanical and shape memory properties at the application-specific ultra low densities. This work is aimed at further expanding the utility of these biomaterials, as implantable low density shape memory polymer foams, by introducing controlled biodegradability. A highly covalently crosslinked network structure was maintained by use of low molecular weight, symmetrical and polyfunctional hydroxyl monomers such as Polycaprolactone triol (PCL-t, Mn 900 g), N,N,N0,N0-Tetrakis (hydroxypropyl) ethylenediamine (HPED), and Tris (2-hydroxyethyl) amine (TEA). Control over the degradation rate of the materials was achieved by changing the concentration of the degradable PCL-t monomer, and by varying the material hydrophobicity. These porous SMP materials exhibit a uniform cell morphology and excellent shape recovery, along with controllable actuation temperature and degradation rate. We believe that they form a new class of low density biodegradable SMP scaffolds that can potentially be used as “smart” non-permanent implants in multiple minimally invasive biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low density biodegradable shape memory polyurethane foams for embolic biomedical applications

et al. 2014

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“…An important class of such materials are shape memory polymers (SMPs) . These can be deformed and fixed in a temporary shape until they are exposed to an environmental stimulus, i.e., temperature, organic solvent, mechanical stress, electromagnetic fields, and react to that by recovering their original, permanent shape. Besides conventional SMPs that are capable to switch between two shapes, recently multiple‐shape memory polymers have been introduced .…”

Section: Introductionmentioning

confidence: 99%

Tunable Multiple‐Shape Memory Polyethylene Blends

Hoeher

Raidt

Krumm

et al. 2013

Macro Chemistry & Physics

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Shape memory polymers (SMPs) are an important class of smart materials. Usually, these polymers can be switched between two shapes. Recently, the possibility of switching more than two shapes was introduced for SMPs with relatively low strain storage capability. In this work, a lightly cross-linked polyethylene blend comprising 80 wt% EOC, 15 wt% LDPE, and 5 wt% HDPE is prepared in order to obtain a tunable multiple-shape memory polymer with high strain storage capacity. It is found that depending on the programming procedure, this SMP obtains a dual-, triple-, or quadruple-shape memory effect, with well-defi ned intermediate temporary shapes (retraction < 0.5% K −1 ) over a signifi cantly broad temperature range (up to 30 K), large storable strains (up to 1700%), and nearly full recovery of all shapes ( > 98.9%). transition range. [14][15][16][17][18] For instance, Xie [ 19 ] obtained a tunable multiple-shape memory for PFSA (perfl uorosulfonic acid ionomer), which possesses a broad glass transition from 55 to 130 ° C, by correlating certain temporary shapes to different temperatures within its glass transition range. Kolesov and Radusch [ 20 ] showed a triple-shape memory for cross-linked polyethylene blends of HDPE and two different ethylene-1-octene copolymers (EOC), by correlating different temporary shapes to distinct temperatures within a broad melting range. With this system, they were able to store strains of up to 100% with an intermediate shape at 44%. In general, multiple-shape memory polymers store strains of up to 240%, which limit the relative retraction response. We have recently found that the stored strain of PE-SMPs can be greatly enhanced by lowering the degree of cross-linking in a way that the resulting network is at the borderline between thermoplastics and elastomers. [ 21 ] In the present manuscript, this concept is extended to polyethylene blends in order to obtain a tunable multiple-shape memory polymer with large strain storage capability. Experimental Section MaterialsHigh density polyethylene (HDPE) (Lupolen 6021D, M w = 220 000 g mol −1 , PDI = 10, 0.5 branches per 1000 C atoms) [ 22 ]

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“…Finally, no statistically significant change in the FTIR spectra was noticed for the 0P-HDI composition (control) throughout the degradation period, which is again in agreement with its negligible mass loss. Several biodegradable SMPs have been reported in the literature [194]. A recent review by Behl et al reports biodegradable SMPs developed in the four primary SMP network structure categories of covalently crosslinked crystalline and amorphous networks, and physically crosslinked crystalline and amorphous networks [194].…”

Section: Mass Lossmentioning

confidence: 99%

“…Several biodegradable SMPs have been reported in the literature [194]. A recent review by Behl et al reports biodegradable SMPs developed in the four primary SMP network structure categories of covalently crosslinked crystalline and amorphous networks, and physically crosslinked crystalline and amorphous networks [194].…”

Section: Mass Lossmentioning

confidence: 99%

Ultra Low Density Shape Memory Polymer Foams With Tunable Physicochemical Properties for Treatment of intracranial Aneurysms

Singhal

2013

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Biodegradable Shape‐Memory Polymers

Cited by 5 publications

References 80 publications

Low density biodegradable shape memory polyurethane foams for embolic biomedical applications

Low density biodegradable shape memory polyurethane foams for embolic biomedical applications

Tunable Multiple‐Shape Memory Polyethylene Blends

Ultra Low Density Shape Memory Polymer Foams With Tunable Physicochemical Properties for Treatment of intracranial Aneurysms

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