Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)–poly(ethylene glycol)–poly(trimethylene carbonate) macromonomers and nanoclay particles

Sharifi, Shahriar; Blanquer, Sébastien; Kooten, Theo G. van; Grijpma, Dirk W.

doi:10.1016/j.actbio.2012.09.014

Cited by 73 publications

(43 citation statements)

References 38 publications

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“…Natural polymers, i.e., alginate and methyl cellulose, have been used for the preparation of clay NC gels. 16 poly(ethylene oxide)-block-poly(propylene oxide)-blockpoly(ethylene oxide), 18 and poly(trimethylene carbonate) -block-PEG-block-poly(trimethylene carbonate), 19 NC gels with good biocompatibility and enhanced mechanical properties can be fabricated without sacrificing their biocompatibility. In addition, the incorporated clay nanoparticles might also act as drug reservoirs, 20 21 which released drug in stomach and intestine with reduced/no burst release in initial period.…”

Section: Nanocomposite Hydrogelmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

220

101

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Traditional hydrogels usually possess inferior mechanical properties as well as lacking multi-functionalities. Nano-sized particles/fillers, both inorganic and organic materials, have unique chemical, physical, and biological functions, and have been extensively studied as biomaterials or bio-functional materials. Nanocomposite hydrogels, which combine the advantages of both nano-fillers and hydrogel matrices, may result in improved mechanical and biological properties and find their potential applications in biomedical field. This paper reviews recent developments in the synthesis, preparation, and characterization of nanocomposite hydrogels; their biomedical applications, such as drug delivery matrices and tissue engineering scaffolding materials are also summarized.

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Section: Nanocomposite Hydrogelmentioning

confidence: 99%

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Song¹,

Li²,

Wang³

et al. 2015

j biomed nanotechnol

220

101

View full text Add to dashboard Cite

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“…To crosslink saturated elastomers (such as ethylene propylene rubber) or unsaturated ones (such as PB) numerous approaches have been developed thus far including sulfur systems, peroxides, urethane crosslinkers and so on [10][11][12][13]. But, in some special technologies (such as coating) or applications (such as in-vivo implantation) different processes like photoinitiating systems are needed for in-situ crosslinking of resins [3,[14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

In-situ photocrosslinkable nanohybrid elastomer based on polybutadiene/polyhedral oligomeric silsesquioxane

Mirmohammadi

Nekoomanesh‐Haghighi

Gezaz

et al. 2016

Materials Science and Engineering: C

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Hydroxyl functionalized nano-sized POSS or ethyleneglycol as diol monomers was incorporated to hydroxyl-terminated polybutadiene (HTPBD) chain in the presence of fumaryl chloride as extender. Blue light photocrosslinking system based on camphorquinone (photoinitiator) and dimethylaminoethyl methacrylate (accelerator) was applied to cure these two synthesized fumarate based macromers. Self-crosslinkability of unsaturated macromers and also crosslinking in presence of a reactive diluent were investigated in absence and presence of 1,4-butanediol dimethacrylate, respectively. Finally, photocured samples were characterized by XRD, SEM, equilibrium swelling study, TGA, DMTA, AFM and cell culture. The results showed that incorporation of POSS nanoparticle into the polymer matrix with a perfect distribution and dispersion can enhance thermal stability, mechanical and biocompatibility properties which can prove a good potential of this in-situ photocrosslinkable nanohybrid in medical applications.

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“…Sharifi et al [93] produced soft nanocomposite hydrogel structures by the polymerization of a solution, consisting of methacrylate-functionalized triblock copolymers of PEG and PTMC with colloidal dispersions of clay nanoparticles (Laponite …”

Section: Polymer/ceramic Blendsmentioning

confidence: 99%

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Pereira

Bartolo

2014

Tissue Engineering

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Stereolithography is an additive technique that produces three-dimensional (3D) solid objects using a multi-layer procedure through the selective photoinitiated curing reaction of a liquid photosensitive material. Stereolithographic processes have been widely employed in Tissue Engineering for the fabrication of temporary constructs, using natural and synthetic polymers, and polymer-ceramic composites. These processes allow the fabrication of complex structures with a high accuracy and precision at physiological temperatures, incorporating cells and growth factors without significant damage or denaturation. Despite recent advances on the development of novel biomaterials and biocompatible crosslinking agents, the main limitation of these techniques are the lack number of available photocrosslinkable materials, exhibiting appropriate biocompatibility and biodegradability. This chapter gives an overview of the current state-of-art of materials and stereolithographic techniques to produce constructs for tissue regeneration, outlining challenges for future research.

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Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)–poly(ethylene glycol)–poly(trimethylene carbonate) macromonomers and nanoclay particles

Cited by 73 publications

References 38 publications

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

Nanocomposite Hydrogels and Their Applications in Drug Delivery and Tissue Engineering

In-situ photocrosslinkable nanohybrid elastomer based on polybutadiene/polyhedral oligomeric silsesquioxane

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

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