Biodegradable metallic bone implants

Shuai, Cijun; Li, Sheng; Peng, Shuping; Feng, Pei; Lai, Yuxiao; Gao, Chengde

doi:10.1039/c8qm00507a

Cited by 174 publications

(102 citation statements)

References 169 publications

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“…Cytocompatibility. Good biocompatibility was of great significance for the bone implants [49][50][51]. In present study, the PLLA/0.5CNTs scaffold with optimal mechanical properties was used to further evaluate the cytocompatibility, with the PLLA scaffold as control.…”

Section: Discussionmentioning

confidence: 99%

Crystallinity and Reinforcement in Poly-L-Lactic Acid Scaffold Induced by Carbon Nanotubes

Wang

Yang

et al. 2019

Advances in Polymer Technology

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Poly-L-Lactic Acid (PLLA) is a bioabsorbable implant material due to its favorable biocompatibility and inherent degradability, while the insufficient mechanical strength hinders its further bone repair application. In present work, carbon nanotubes (CNTs) were introduced into PLLA scaffolds fabricated via selective laser sintering. It was found that the crystallinity of PLLA increased considerably since CNTs could promote the orderly stacking of its molecular chains, thereby improving the mechanical strength of PLLA scaffold. Furthermore, the fracture surface analysis revealed that CNTs acted as a bridge across the cracks and hindered their further expansion. Moreover, CNTs pulled out from the matrix to consume a large amount of fracture energy, which enhanced the resistance to external forces. As a consequence, the compressive strength, Vickers hardness and tensile strength of the scaffold were enhanced by 22.7%, 58.8% and 17.6%, respectively. Besides, the cells exhibited good attachment, spreading and proliferation on the scaffold. This study demonstrated that PLLA/CNTs scaffold was a promising candidate as bone implant.

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Section: Discussionmentioning

confidence: 99%

Crystallinity and Reinforcement in Poly-L-Lactic Acid Scaffold Induced by Carbon Nanotubes

Wang

Yang

et al. 2019

Advances in Polymer Technology

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“…Although there are numerus Reviews focusing on the design and degradation pattern of biodegradable metals,24,25 testing methods of corrosion mode of Mg‐based metals,21 current reported clinical trials,20 and interaction between biomaterials and cells,26 it still remains unclear with regards to the repair mechanism of Mg ions in bone fracture repair, extension of future clinical indications, and strategies for its application at high weight‐bearing skeletal sites. Therefore, we would like to address these questions in this Review and hope to broaden our understanding on its basic medical sciences and extend the use of Mg‐based implants in orthopedics.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

et al. 2020

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Biodegradable Mg‐based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg‐based orthopedic implants. First, the properties between Mg‐based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg‐based implants, peri‐implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg‐containing hybrid systems) are discussed to address the limitations of Mg‐based metals prior to their clinical applications at weight‐bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg‐based orthopedic implants are discussed. Taken together, the progress made on the development of Mg‐based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

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“…The electrochemical behaviors of Fe/Mg 2 Si composites were tested by an IM6 electrochemical workstation (Zahner, Germany) in simulated body fluid (SBF) at 37°C. The SBF with a pH of 7.4 contained 8.035 g·L −1 NaCl, 0.225 g·L −1 KCl, 0.311 g·L −1 MgCl 2 ·6H 2 O, 0.231 g·L −1 K 2 HPO 4 ·3H 2 O, 6.118 g·L −1 (CH 2 OH) 3 CNH 2 , 0.355 g·L −1 NaHCO 3 , 0.292 g·L −1 CaCl 2 , and 0.072 g·L −1 Na 2 SO 4 [ 2 , 35 ]. The typical three-electrode cell, containing the saturated calomel electrode (SCE, reference electrode), the sample (working electrode), and the platinum electrode (auxiliary electrode), was used to perform electrochemical tests.…”

Section: Methodsmentioning

confidence: 99%

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Shuai

Peng

et al. 2020

IJB

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Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg2Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg2Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg2Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg2Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.

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Biodegradable metallic bone implants

Abstract: This review summarizes the current research status on biodegradable metals as bone implants, including their biodegradability, mechanical properties, and biocompatibility.

Cited by 174 publications

References 169 publications

Crystallinity and Reinforcement in Poly-L-Lactic Acid Scaffold Induced by Carbon Nanotubes

Crystallinity and Reinforcement in Poly-L-Lactic Acid Scaffold Induced by Carbon Nanotubes

Biodegradable Magnesium‐Based Implants in Orthopedics—A General Review and Perspectives

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

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