Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging

Watcharin, Waralee; Schmithals, Christian; Pleli, Thomas; Köberle, Verena; Korkusuz, H.; Huebner, Frank; Zeuzem, Stefan; Korf, Hans W.; Vogl, Thomas J.; Rittmeyer, Claudia; Terfort, Andreas; Piiper, Albrecht; Gelperina, Svetlana; Kreuter, Jörg

doi:10.1016/j.ejpb.2013.12.010

Cited by 37 publications

(24 citation statements)

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“…However, a recent study argue against the involvement of SPARC in nab-paclitaxel treatment of metastatic breast cancer [280]. More recent examples are biodegradable albumin-based nanoparticles containing contrast agents for magnetic resonance imaging of hepatocellular carcinoma [281], iron-oxide containing magnetic nanoparticles for tumor imaging [227], anti-elastin antibody and EDTA-loaded nanoparticles for targeting to degraded elastic lamina of vascular diseases [228,229] as well as inhalable nanoparticles containing drugs targeting lung cancer [230]. Examples of therapeutic molecules that have been encapsulated in albumin-based nanoparticles are listed in Table 2.…”

Section: Albumin-based Nanoparticlesmentioning

confidence: 99%

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

Bern

Sand

Nilsen

et al. 2015

Journal of Controlled Release

162

135

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Section: Albumin-based Nanoparticlesmentioning

confidence: 99%

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

Bern

Sand

Nilsen

et al. 2015

Journal of Controlled Release

162

135

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“…hydroxysulfo-succinimide (sulfo-NHS) reaction with incubation at room temperature for 3 h to prepare rhodamine labelled nanoparticles [23,24]. The labelled nanoparticles were subjected to dialysis against deionized water to remove any excess dye.…”

Section: Development Of Artemether-loaded Hsa Nanoparticlesmentioning

confidence: 99%

Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes

Sidhaye¹,

Bhuran²,

Zambare³

et al. 2016

Nanomedicine

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Aim: The intra-erythrocytic development of the malarial parasite is dependent on active uptake of nutrients, including human serum albumin (HSA), into parasitized red blood cells (pRBCs). We have designed HSA-based nanoparticles as a potential drug-delivery option for antimalarials. Methods: Artemether-loaded nanoparticles (AAN) were designed and antimalarial activity evaluated in-vitro/in-vivo using Plasmodium falciparum/Plasmodium berghei species, respectively. Results: Selective internalisation of AAN into Plasmodiuminfected RBCs in preference to healthy erythrocytes was observed using confocal-imaging.In-vitro studies showed 50% dose reduction for AAN as compared to drug-only controls to achieve IC50 levels of inhibition. The nanoparticles exhibited 2-fold higher peak drug concentrations in RBCs with antimalarial activity at 50% of therapeutic doses in P.bergeiinfected mice. Conclusion: HSA-based nanoparticles offer safe and effective approach for selective targeting of antimalarial drugs.

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“…The signal intensities measured for the T1-weighed MRI were in good accordance with the ICP results. Earlier studies reported 4.7-8.5 mg Gd/g nanoparticle concentration in HSA nanoparticles after covalent linking of DTPA to the protein nanoparticles obtained by desolvation, which was found to be considerably high for in vivo MRI studies [5].…”

Section: Evaluation Of Contrast Signal Using In Vitro Mrimentioning

confidence: 97%

“…Theranostic nanodelivery systems offer a versatile combination of therapeutic and diagnostic features and have been applied to this task earlier [3,4]. A variety of contrast agents such as gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), shorten the longitudinal relaxation time, and were widely used for both vascular and tumor magnetic resonance imaging (MRI) [4,5]. One major limitation of this technique lies in the short half-life of the contrast agent as well as the poor specificity for the target site.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, Gd-DTPA-conjugated human serum albumin (HSA) nanoparticles improved the contrast of MRI compared to Gd-DTPA aqueous solution in vivo [3][4][5]. Unfortunately, even after conjugation of polyethylene glycol (PEG) to the particle surface, HSA nanoparticles exhibit only short circulation time [6] and the potential for scale-up of this technology is rather limited [7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

Feczkó¹,

Piiper²,

Pleli³

et al. 2019

Preprint

Self Cite

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Background: Efficient delivery of the poorly water-soluble compound sorafenib still poses a challenge to current formulation strategies. To incorporate the lipophilic molecule into biocompatible and biodegradable theranostic nanoparticles has great potential for improving efficacy and safety of cancer therapy. Results: In this study, sorafenib nanoencapsulation was optimized using poly(D,L-lactide-co-glycolide) and polyethylene glycol-poly(D,L-lactide-co-glycolide) copolymers comparing three different technologies. The particles ranged in size between 220 and 240 nm with encapsulation efficiencies from 76.1 ± 1.7 % to 69.1 ± 10.1 %. A remarkable maximum drug load of 9.0 % was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface transforming the nanospheres into theranostic devices allowing the localization using magnetic resonance imaging. Conclusion: The manufacture of sorafenib-loaded nanoparticles and the functionalization of the particle surface with a gadolinium complex resulted in a high drug loading, a strong MRI signal, optimal stability features and a sustained release profile.

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Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging

Cited by 37 publications

References 50 publications

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

Bio-inspired artemether-loaded human serum albumin nanoparticles for effective control of malaria-infected erythrocytes

Theranostic polymeric nanocarriers modified by enhanced gadolinium conjugation techniques

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