Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine

Fukuhira, Yukako; Kitazono, Eiichi; Hayashi, Takami; Kaneko, Hiroaki; Tanaka, Masaru; Shimomura, Masatsugu; Sumi, Yôichi

doi:10.1016/j.biomaterials.2005.10.019

Cited by 114 publications

(96 citation statements)

References 12 publications

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“…Although the initial roughness of these substrate types is initially challenging, the roughness level could be lowered either by adjusted fabrication parameters or by additional (bio)coatings. Another biodegradable and well investigated polymer for substrate use is poly lactic acid [14]. For further detailed information about this material class, the authors recommend the excellent overview about biodegradable polymers given by Breulmann and co-workers [15].…”

Section: Substrate Materialsmentioning

confidence: 99%

“…The semiconductors are used as gate-controlled charge transport material between the source and drain electrodes [23]. Additionally, natural chlorophyll, hemin, phenazine, terpenoid molecules and indigo (13a) are listed as natural p-and n-type semiconductors, whereas nature inspired materials such as indanthrene yellow G, brilliant orange RF, epindolidione (14), perylene diimide (15) [27] and also determined the charge carrier mobilities in the range of ~10 −4 cm 2 V −1 ·s −1 when applied in OTFTs. Ambipolar indigoids and quindacridones showed the most promising semiconductor properties due to their long-range order, crystallinity and highly dielectric characteristics.…”

Section: Organic Semiconductorsmentioning

confidence: 99%

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Bio-Organic Electronics—Overview and Prospects for the Future

Mühl

Beyer

2014

Electronics

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Abstract:In recent years, both biodegradable and bio-based electronics have attracted increasing interest, but are also controversially discussed at the same time. Yet, it is not clear whether they will contribute to science and technology or whether they will disappear without major impact. The present review will address several aspects while showing the potential opportunities of bio-organic electronics. An overview about the complex terminology of this emerging field is given and test methods are presented which are used to evaluate the biodegradable properties. It will be shown that the majority of components of organic electronics can be substituted by biodegradable or bio-based materials. Moreover, application scenarios are presented where bio-organic materials have advantages compared to conventional ones. A variety of publications are highlighted which encompass typical organic devices like organic light emitting diodes, organic solar cells and organic thin film transistors as well as applications in the field of medicine or agriculture.

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Section: Substrate Materialsmentioning

confidence: 99%

Section: Organic Semiconductorsmentioning

confidence: 99%

Bio-Organic Electronics—Overview and Prospects for the Future

Mühl

Beyer

2014

Electronics

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“…32 The film has a unique surface structure, characterized by pores of a Okuda et al A honeycomb-patterned film that prevents wound adhesion in filtration surgery -6 -hexagonal shape interconnecting horizontally along the film surface on one side.…”

Section: The Honeycomb-patterned Filmmentioning

confidence: 99%

“…32 It has a honeycomb structure that allows tissue attachment on one side and a smooth structure that prevents adhesion on the other side. Therefore, the film can stick to the tissue surface on the honeycomb side, while preventing adhesion of other tissues to the smooth side.…”

Section: Introductionmentioning

confidence: 99%

A Thin Honeycomb-patterned Film as an Adhesion Barrier in an Animal Model of Glaucoma Filtration Surgery

Okuda

Higashide

Fukuhira

et al. 2009

Journal of Glaucoma

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Purpose. To evaluate the effectiveness and safety of a thin honeycomb-patterned biodegradable film for glaucoma filtration surgery in rabbits.Methods. A 7μm-thick film made from poly(L-lactide-co-ε-caprolactone) was placed in the subconjunctival space in one eye of rabbits, with or without full-thickness filtration surgery. The film had a honeycomb-patterned surface that faced the subconjunctival Tenon tissue and the other side was smooth. Filtration surgery was also performed in the fellow eye, which received either no adjunctive treatment or 0.4 mg/ml mitomycin C (MMC; n=6 each). Intraocular pressure (IOP) measurements and bleb evaluations using ultrasound biomicroscopy were performed periodically for 28 days after surgery followed by histological observation.Results. Postoperative IOPs of the film-treated eyes were significantly lower than that of control eyes from day 10 to day 28 (P<0.05), but were not significantly different from those of MMC-treated eyes. The subconjunctival filtration space, detected by ultrasound biomicroscopy, disappeared in five control eyes, one MMC-treated eye, but none of the film-treated eyes. A bleb leak occurred postoperatively in two MMC-treated eyes. Histologically, in eyes without filtration surgery, fibrotic tissue with the film partly attached to it was noted on the honeycomb side, but was minimal on the sclera that faced the smooth side of the film. In eyes with filtration surgery, the honeycombpatterned film lined the inner bleb wall with minimal inflammatory reaction.Conclusions. The thin honeycomb-patterned film that attached to the inner bleb wall worked as an adhesion barrier in glaucoma filtration surgery in rabbits, which is worthy of further investigation. Methods. A 7μm-thick film made from poly(L-lactide-co-ε-caprolactone) was placed in the subconjunctival space in one eye of rabbits, with or without full-thickness filtration surgery. The film had a honeycomb-patterned surface that faced the subconjunctival Tenon tissue and the other side was smooth. Filtration surgery was also performed in the fellow eye, which received either no adjunctive treatment or 0.4 mg/ml mitomycin C (MMC; n=6 each). Intraocular pressure (IOP) measurements and bleb evaluations using ultrasound biomicroscopy were performed periodically for 28 days after surgery followed by histological observation.Results. Postoperative IOPs of the film-treated eyes were significantly lower than that of control eyes from day 10 to day 28 (P<0.05), but were not significantly different from those of MMC-treated eyes. The subconjunctival filtration space, detected by ultrasound biomicroscopy, disappeared in five control eyes, one MMC-treated eye, but none of the film-treated eyes. A bleb leak occurred postoperatively in two MMC-treated eyes. Histologically, in eyes without filtration surgery, fibrotic tissue with the film partly attached to it was noted on the honeycomb side, but was minimal on the sclera that faced the smooth side of the film. In eyes with filtration surgery, the honeycomb-pattern...

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“…Porous films were prepared by the BF method, generally as described elsewhere [30] and as simply illustrated in Figure 1 A. Solutions of the copolymer 96/4 L-lactide/D-lactide (PLDLA, purified, medical grade, IV midpoint 2.0 dl/g, PURASORB PLD 9620, Corbion Purac, Netherlands) and the surfactant dioleoyl phosphatidylethanolamine (DOPE, Sigma, Japan) were initially prepared in chloroform to a concentration of 10 mg ml -1 and 0.1 mg ml -1 , respectively.…”

Section: Preparation Of Honeycomb Filmsmentioning

confidence: 99%

Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering

et al. 2017

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Age-related macular degeneration (AMD) is the leading cause of vision loss in senior citizens in the developed world. The disease is characterised by the degeneration of a specific cell layer at the back of the eye -the retinal pigment epithelium (RPE), which is essential in retinal function. The most promising therapeutic option to restore the lost vision is considered to be RPE cell transplantation. This work focuses on the development of biodegradable biomaterials with similar properties to the native Bruch's membrane as carriers for RPE cells. In particular, the breath figure (BF) method was used to create semi-permeable microporous films, which were thereafter used as the substrate for the consecutive Langmuir-Schaefer (LS) deposition of highly organised layers of collagen type I and collagen type IV. The newly developed biomaterials were further characterised in terms of surface porosity, roughness, hydrophilicity, collagen distribution, diffusion properties and hydrolytic stability.Human embryonic stem cell-derived RPE cells (hESC-RPE) cultured on the biomaterials showed good adhesion, spreading and morphology, as well as the expression of specific protein markers. Cell function was additionally confirmed by the assessment of the phagocytic capacity of hESC-RPE.Throughout the study, microporous films consistently showed better results as cell culture materials for 2 hESC-RPE than dip-coated controls. This work demonstrates the potential of the BF-LS combined technologies to create biomimetic prosthetic Bruch's membranes for hESC-RPE transplantation.

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Biodegradable honeycomb-patterned film composed of poly(lactic acid) and dioleoylphosphatidylethanolamine

Cited by 114 publications

References 12 publications

Bio-Organic Electronics—Overview and Prospects for the Future

Bio-Organic Electronics—Overview and Prospects for the Future

A Thin Honeycomb-patterned Film as an Adhesion Barrier in an Animal Model of Glaucoma Filtration Surgery

Langmuir-Schaefer film deposition onto honeycomb porous films for retinal tissue engineering

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