Biodegradable Dual-Cross-Linked Hydrogels with Stem Cell Differentiation Regulatory Properties Promote Growth Plate Injury Repair via Controllable Three-Dimensional Mechanics and a Cartilage-like Extracellular Matrix

Guan, Pengfei; Ji, Yuelun; Kang, Xinchang; Liu, Weilu; Yang, Qinfeng; Liu, Shencai; Lin, Yeying; Zhang, Zuyu; Li, Junji; Zhang, Yue; Liu, Can; Fan, Lei; Sun, Yongjian

doi:10.1021/acsami.2c20722

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…Guan-synthesized three-dimensional hydrogels encapsulating bone marrow mesenchymal stem cells (BMSCs) use oxidized chondroitin sulfate via dynamic Schiff base bonding. The transformation of BMSCs into chondrocytes and the repair of damaged growth plates were facilitated [ 47 ]. Hao et al demonstrated that chondroitin sulfate is involved in biomineralization in its free state which promotes bone tissue repair [ 48 ].…”

Section: Hydrogel Materialsmentioning

confidence: 99%

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

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Infected bone defects represent a common clinical condition involving bone tissue, often necessitating surgical intervention and antibiotic therapy. However, conventional treatment methods face obstacles such as antibiotic resistance and susceptibility to postoperative infections. Hydrogels show great potential for application in the field of tissue engineering due to their advantageous biocompatibility, unique mechanical properties, exceptional processability, and degradability. Recent interest has surged in employing hydrogels as a novel therapeutic intervention for infected bone repair. This article aims to comprehensively review the existing literature on the anti-microbial and osteogenic approaches utilized by hydrogels in repairing infected bones, encompassing their fabrication techniques, biocompatibility, antimicrobial efficacy, and biological activities. Additionally, the potential opportunities and obstacles in their practical implementation will be explored. Lastly, the limitations presently encountered and the prospective avenues for further investigation in the realm of hydrogel materials for the management of infected bone defects will be deliberated. This review provides a theoretical foundation and advanced design strategies for the application of hydrogel materials in the treatment of infected bone defects.

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Section: Hydrogel Materialsmentioning

confidence: 99%

Repair of Infected Bone Defects with Hydrogel Materials

Cao,

Qin,

Duns

et al. 2024

Polymers

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“…Thus, GMOCS hydrogels can achieve sustained release of active ingredients and affect the differentiation trend of MSCs, thus provide a good niche for promoting the repair of growth plates injury and cartilage regeneration. Their safety and feasibility for clinical conversion can be further evaluated in the future 167 (Table 2).…”

Section: Introductionmentioning

confidence: 99%

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

et al. 2023

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The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

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Composite Hydrogel Containing Collagen‐Modified Polylactic Acid‐Hydroxylactic Acid Copolymer Microspheres Loaded with Tetramethylpyrazine Promotes Articular Cartilage Repair

Pan,

Li,

Sun

et al. 2024

Macromolecular Bioscience

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Articular cartilage defects pose a significant challenge due to the limited self‐healing ability of cartilage. However, traditional techniques face limitations including autologous chondrocyte expansion issues. This study aims to investigate the effects of collagen‐surface modified polylactic acid‐glycolic acid (PLGA) microspheres (CPLGA) loaded with tetramethylpyrazine (TMP) on two cell types and the regeneration potential of articular cartilage. PLGA microspheres are fabricated using an emulsification‐solvent evaporation method, followed by surface grafting of type II collagen through the Steglich reaction. Microsphere identification is performed using FTIR, XPS, and fluorescence labeling. Additionally, the protein‐grafting rate, physical properties, drug loading, and drug release curves of microspheres are characterized. We evaluated the effects of TMP‐loaded microspheres on the proliferation and migration of HUVEC, and examined the antioxidant capacity, angiogenesis, and apoptosis related gene expression of HUVEC, and evaluated the compatibility of blank microspheres with bone marrow mesenchymal stem cells and their potential to promote cartilage differentiation. We evaluate the compatibility of microspheres with BMSCs and their potential to promote chondrogenic differentiation. Subcutaneous implant immune tests and cartilage defect treatment are conducted to assess biocompatibility and cartilage repair potential. The results highlight the efficacy of CPLGA microspheres in promoting tissue regeneration, attributed to improved hydrophilicity and collagen‐induced mitigation of degradation. Under hypoxic conditions, both CPLGA and PLGA TMP‐loaded microspheres exhibit inhibitory effects on HUVEC proliferation, migration, and angiogenesis. Notably, CPLGA microspheres show enhanced compatibility with BMSCs, facilitating chondrogenic differentiation. Moreover, the CPLGA microsphere‐composite hydrogel exhibits potential for cartilage repair by modulating angiogenesis and promoting BMSC differentiation.This article is protected by copyright. All rights reserved

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Biodegradable Dual-Cross-Linked Hydrogels with Stem Cell Differentiation Regulatory Properties Promote Growth Plate Injury Repair via Controllable Three-Dimensional Mechanics and a Cartilage-like Extracellular Matrix

Cited by 7 publications

References 53 publications

Repair of Infected Bone Defects with Hydrogel Materials

Repair of Infected Bone Defects with Hydrogel Materials

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Composite Hydrogel Containing Collagen‐Modified Polylactic Acid‐Hydroxylactic Acid Copolymer Microspheres Loaded with Tetramethylpyrazine Promotes Articular Cartilage Repair

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