Biodegradable ceramic-polymer composites for biomedical applications: A review

Dziadek, Michał; Stodolak-Zych, Ewa; Cholewa‐Kowalska, Katarzyna

doi:10.1016/j.msec.2016.10.014

Cited by 167 publications

(93 citation statements)

References 186 publications

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“…Porous biomaterials for TE have to meet several requirements: (1) uniformly distributed and interconnected highly porous structure with suitable pore size and shape to provide adequate space for cells seeding or growth, blood vessel ingrowth and flow transport of nutrients and metabolic waste; (2) biodegradable or bioresorbable with a controllable degradation and resorption rate, appropriate to match tissue growth in vivo and with non-cytotoxic degradation products; (3) suitable surface topography, chemistry and wettability for cell attachment, proliferation and differentiation; (4) mechanical properties matching those of the tissues at the site of implantation [2,6,7]. Furthermore, materials for bone tissue engineering (BTE) should possess bone-bonding ability, as well as osteoconductive/osteoinductive properties [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…bioactive glasses, glass-ceramics, silica, wollastonite, calcium phosphates) in biodegradable polymer matrix is another strategy for modulating a number of properties of porous materials for TE [3,8]. Such approach is particularly suitable for BTE applications because of the polymer/ceramic composites ability to mimic the structure of natural bone [9].…”

Section: Introductionmentioning

confidence: 99%

“…Such composites combine excellent biocompatibility, relatively high mechanical strength, ease of processing, as well as low degradation rate of PCL [9,[18][19][20] with excellent bone-bonding ability, osteoconductive and/or osteoinductive character, stiffness and high hydrophilicity of bioactive glasses [8,9,18,21,22]. Furthermore, there is a possibility to use sol-gel-derived glass particles that have a larger surface area and -OH groups present in their structure, and therefore usually exhibit higher bioactivity than conventional melt-derived glasses [23,24].…”

Section: Introductionmentioning

confidence: 99%

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Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Dziadek¹,

Zagrajczuk²,

Menaszek

et al. 2017

J Mater Sci

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In contrast to currently used materials, membranes for the treatment of bone defects should actively promote regeneration of bone tissue beyond their physical barrier function. What is more, both material properties and biological features of membranes should be easily adaptable to meet the needs of particular therapeutic applications. Therefore, the role of preparation methods (nonsolvent-induced phase separation and thermal-induced phase separation) of poly(ε-caprolactone)-based membranes and their modification with gel-derived bioactive glass (BG) particles of two different sizes (\45 and \3 μm) in modulating material morphology, polymer matrix crystallinity, surface wettability, kinetics of in vitro bioactivity and also osteoblast response was investigated. Both surfaces of membranes were characterised in terms of their properties. Our results indicated a possibility to modulate microstructure (pore size ranging from submicron to hundreds of micrometres), wettability (from hydrophobic to fully wettable surface) and polymer crystallinity (from 19 to 60%) in a wide range by the use of various preparation methods and different BG particle sizes. Obtained composite membranes showed excellent in vitro hydroxyapatite forming ability after incubation in simulated body fluid. Here we demonstrated that bioactive layer formation on the surface of membranes occurred through ACP-OCP-CDHA-HCA transformation, that mimic in vivo bone biomineralization process. Composite membranes supported human osteoblast proliferation, stimulated cell differentiation and matrix mineralization. We proved that kinetics of bioactivity process and also osteoinductive properties of membranes can be easily modulated with the use of proposed variables. This brings new

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Dziadek¹,

Zagrajczuk²,

Menaszek

et al. 2017

J Mater Sci

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“…Functional polymer‐based composite films have recently attracted attention as prospective materials in a wide range of applications including sensorics, optoelectronics, organic light‐emitting diodes (which demand materials with high luminescence properties), and high‐performance electrodes for supercapacitors . Polymers are promising materials in electronics due to high transparency, high flexibility, and solution‐processing properties .…”

Section: Introductionmentioning

confidence: 99%

“…Functional polymer-based composite films have recently attracted attention as prospective materials in a wide range of applications including sensorics, optoelectronics, organic light-emitting diodes (which demand materials with high luminescence properties), and high-performance electrodes for supercapacitors. [1][2][3][4][5][6] Polymers are promising materials in electronics due to high transparency, high flexibility, and solution-processing properties. 7 Although indium tin oxide and fluorine tin oxide are widely used as a transparent electrode material for optoelectronic devices, their mechanical flexibility is insufficient for stretchable plasmonic devices, and implantable and other flexible device applications.…”

Section: Introductionmentioning

confidence: 99%

Composite multilayer films based on polyelectrolytes and in situ‐formed carbon nanostructures with enhanced photoluminescence and conductivity properties

Ermakov

Prikhozhdenko

Demina

et al. 2019

J of Applied Polymer Sci

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We report a facile route for the fabrication of thin composite films based on polyelectrolytes and carbon nanostructures. Composite films were made by layer‐by‐layer assembly of polyelectrolyte multilayers utilizing embedded dextran sulfate (Dex) solution as a carbon source. Raman measurements indicate the formation of carbon nanostructures from the Dex precursor over the whole film. Formation of these nanostructures results in enhanced photoluminescence and an increase in conductivity by two orders of magnitude to about 0.055 S cm−1. The latter corresponds to the level of wide‐gap semiconductors, in contrast to the initial insulating polyelectrolyte film. A distinct peak of photoluminescence of the films is found in the blue region at the wavelength of 450 nm. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47718.

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Potential of Graphene–Polymer Composites for Ligament and Tendon Repair: A Review

et al. 2020

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Tendon/ligament injuries are debilitating conditions that affect the life quality of a great percentage of the adult population. Several challenges still have to be addressed regarding the repair of these tissues, as current treatments show limited success. The use of biocompatible and biodegradable polymeric scaffolds potentially helps accomplish a complete and long‐term functional repair but, unfortunately, these materials lack adequate mechanical properties to be used in such demanding applications. Graphene is a subject of interest for tissue‐repair applications due to its electrical conductivity and mechanical properties. If incorporated adequately, it may significantly improve the physical properties of the composite, even at small loadings. Furthermore, graphene presents a biocompatible surface that may enhance cell adhesion, proliferation and differentiation and demonstrates promising outcomes in several in vitro and in vivo biological applications. Therefore, herein, the potential of graphene materials for the reinforcement of biodegradable polymers of interest for tendon/ligament repair is explored. The effect of graphene on relevant features such as mechanical properties, biodegradability, and biocompatibility is revised, to understand the feasibility of these composites to fulfill the requirements associated with these tissues and conclude how their applicability is extended to this field.

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Biodegradable ceramic-polymer composites for biomedical applications: A review

Cited by 167 publications

References 186 publications

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Poly(ε-caprolactone)-based membranes with tunable physicochemical, bioactive and osteoinductive properties

Composite multilayer films based on polyelectrolytes and in situ‐formed carbon nanostructures with enhanced photoluminescence and conductivity properties

Potential of Graphene–Polymer Composites for Ligament and Tendon Repair: A Review

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