Biodegradability and Safety Study of LifeMesh™, a Novel Self-adhesive Mesh, in Sprague-Dawley Rats

Abstract

Self-adhesive meshes are being developed to avoid complications due to traumatic fixation methods. LifeMesh™ is a novel selfadhesive mesh with a biodegradable gelatin adhesive layer developed for hernia repair. The aim of this study was to assess the safety and biodegradability of LifeMesh in Sprague-Dawley (SD) rats for 6 weeks, in comparison to a bare polypropylene (BPP) mesh fixed with sutures. LifeMesh was tolerated well and its implantation did not result in any adverse local reaction, and its adhesive layer was substantially degraded after 4 weeks. Histopathological examination revealed that the presence of the adhesive contributed to a uniform thickness of the granulation tissue surrounding the mesh, in contrast to a nonuniform granulation tissue with BPP. Nonuniform granulation tissue suggests that there will be poorer integration of the mesh to the abdominal wall. The use of LifeMesh also resulted in less adhesions of internal organs with a smaller surface area of involvement. These findings lend support to the potential benefit of LifeMesh for hernia repair in humans and expand the available information on the typical histopathological findings expected with biodegradable implants in the peritoneal cavity of SD rats.

Local Tolerability and Performance Evaluation in Domestic Pigs of a Fractional Radiofrequency Device for Dermatologic Treatment

“…23 In accordance with the increasing number of medical devices being developed, information on preclinical animal trials with such devices is also growing. [24][25][26][27][28] Specifically for fractional RF devices, it is important to evaluate the consistency and lack of fractional RF effects in the tissue adjacent to the application site, and the lack of any inflammatory reaction at the surrounding tissue. Furthermore, it is essential to observe that normal wound healing process takes place in the application site, with formation of normal skin at this site.…”

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

“…141 A new innovative line of research is the manufacture of self-adhesive meshes based on a biodegradable gelatin layer (LifeMesh™) and PP with largepores and lightweight for hernia repair. 142 In a comparative study between the composite LifeMesh™ and PP meshes, LifeMesh™ showed good tolerance and its implantation did not lead to any adverse local reaction. Its adhesive layer degraded during the 4 weeks after implantation and a histopathological examination revealed that the presence of the adhesive contributed to a uniform thickness of the granulation tissue surrounding the mesh, suggesting that the mesh will better integrate with the abdominal wall.…”

“…The use of this type of mesh resulted in less adherence to the internal organs, which is very important in preventing adverse effects. 142…”

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

“…The recovery after inguinal hernia interventions with Parietex™ Progrip TM showed that this type of mesh is able to significantly reduce the surgery time [136]. A new innovative line of research is the manufacture of self-adhesive meshes based on a biodegradable gelatin layer (LifeMesh™) and PP with largepores and lightweight for hernia repair [137]. In a comparative study between the composite LifeMesh™ and PP meshes, LifeMesh™ showed good tolerance and its implantation did not lead to any adverse local reaction.…”

“…Its adhesive layer degraded during the 4 weeks after implantation and a histopathological examination revealed that the presence of the adhesive contributed to a uniform thickness of the granulation tissue surrounding the mesh, suggesting that the mesh will better integrate with the abdominal wall. The use of this type of mesh resulted in less adherence to the internal organs, which is very important in preventing adverse effects [137].…”