Biocomputers: Problems They Solve, State of the Art, and Prospects

Готовцев, П. М.; Kirillova, D. A.; Василов, Р. Г.

doi:10.1134/s1995078020010036

Cited by 4 publications

(4 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This synergy between AI and organoids, highlights a possible future of biocomputing, integrating advanced biological models with cutting-edge computational technologies. Biologically-based computation faces challenges in standardization, control, and interfacing with digital systems, yet it holds promise for areas where traditional computing falls short [17,18,26,[31][32][33][34]. Despite its nascent stage, there exists much opportunity to explore this emerging domain.…”

Section: On Biocomputing and Organoidsmentioning

confidence: 99%

Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration

Palmer,

Akafia,

Woodson

et al. 2024

Organoids

View full text Add to dashboard Cite

Organoids present immense promise for studying organ systems and their functionality. Recently, they have become the subject of exploration outside of purely biomedical uses in multiple directions. We will explore the rapidly evolving landscape of organoid research over the 21st century, discussing significant advancements in organoid research and highlighting breakthroughs, methodologies, and their transformative impact on our understanding of physiology and modeling. In addition, we will explore their potential use for biocomputing and harnessing organoid intelligence, investigate how these miniaturized organ-like structures promise to create novel computational models and processing platforms allowing for innovative approaches in drug discovery, personalized medicine, and disease prediction. Lastly, we will address the ethical dilemmas surrounding organoid research by dissecting the intricate ethical considerations related to the creation, use, and potential implications of these in vitro models. Through this work, the goal of this paper is to provide introductory perspectives and bridges that will connect organoids to cybersecurity applications and the imperative ethical discourse accompanying its advancements with commentary on future uses.

show abstract

Section: On Biocomputing and Organoidsmentioning

confidence: 99%

Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration

Palmer,

Akafia,

Woodson

et al. 2024

Organoids

View full text Add to dashboard Cite

show abstract

“…The enhancement of cell-to-cell communications and the efficiency of taxis are related to the realization of computational procedures inside the cells [ 70 , 83 , 84 ]. Today, the most common approach is based on genetic logic circuits [ 13 , 64 ].…”

Section: Synthetic Biology Approaches For Microbial Cell-based Micror...mentioning

confidence: 99%

“…The number of logic gates in the single cell can be limited because of the usage of cellular recourse (amino acids, energy intermediates, etc. ), but computation can be separated between different cells with chemical communications for signal transfer [ 83 , 84 ]. Thus, combinations of cells with different goals can be discussed for some applications [ 61 ].…”

Section: Synthetic Biology Approaches For Microbial Cell-based Micror...mentioning

confidence: 99%

Microbial Cells as a Microrobots: From Drug Delivery to Advanced Biosensors

Готовцев

2023

Biomimetics

View full text Add to dashboard Cite

The presented review focused on the microbial cell based system. This approach is based on the application of microorganisms as the main part of a robot that is responsible for the motility, cargo shipping, and in some cases, the production of useful chemicals. Living cells in such microrobots have both advantages and disadvantages. Regarding the advantages, it is necessary to mention the motility of cells, which can be natural chemotaxis or phototaxis, depending on the organism. There are approaches to make cells magnetotactic by adding nanoparticles to their surface. Today, the results of the development of such microrobots have been widely discussed. It has been shown that there is a possibility of combining different types of taxis to enhance the control level of the microrobots based on the microorganisms’ cells and the efficiency of the solving task. Another advantage is the possibility of applying the whole potential of synthetic biology to make the behavior of the cells more controllable and complex. Biosynthesis of the cargo, advanced sensing, on/off switches, and other promising approaches are discussed within the context of the application for the microrobots. Thus, a synthetic biology application offers significant perspectives on microbial cell based microrobot development. Disadvantages that follow from the nature of microbial cells such as the number of external factors influence the cells, potential immune reaction, etc. They provide several limitations in the application, but do not decrease the bright perspectives of microrobots based on the cells of the microorganisms.

show abstract

“…First, there is still no distinct set of particular computational problems that demonstrate a substantial superiority of a biocomputer over modern conventional computational systems. The second basic problem is that computations are slow, being limited by the rates of biochemical reactions" [10]. Other researchers echo this opinion that biocomputers might not likely be competitors to traditional computers in a number of areas, suggesting that the potential applications for biocomputing lie in biosensing, rather than in computation [11].…”

Section: Related Workmentioning

confidence: 99%

Human-Centric Functional Modeling of Biocomputers

Williams¹

2021

Preprint

View full text Add to dashboard Cite

This paper explores how the technique of Human-Centric Functional Modeling might potentially be used to represent a broad subset of proposed implementations of biocomputing with anywhere from narrow to general problem-solving ability within a given domain, or across multiple domains, and how such functional models might be implemented by libraries of biological computing mechanisms. This paper also explores the insights to be gained from modeling biocomputers this way, and how Human-Centric Functional Modeling might significantly accelerate research and increase the impact of research in biocomputing through significantly increasing capacity for reuse of both biocomputing hardware and software.

show abstract

Biocomputers: Problems They Solve, State of the Art, and Prospects

Cited by 4 publications

References 100 publications

Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration

Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration

Microbial Cells as a Microrobots: From Drug Delivery to Advanced Biosensors

Human-Centric Functional Modeling of Biocomputers

Contact Info

Product

Resources

About