Biocompatible, Luminescent Silver@Phenol Formaldehyde Resin Core/Shell Nanospheres: Large‐Scale Synthesis and Application for In Vivo Bioimaging

Abstract

Biocompatible and green luminescent monodisperse silver/phenol formaldehyde resin core/shell spheres with controllable sizes, in the range of 180 to 1000 nm, and interesting architectures (centric, eccentric, and coenocytic core/shell spheres) have been synthesized by a facile one‐step hydrothermal approach. These spheres can be used as bioimaging labels for human lung cancer H1299 cells. The results demonstrate that the nanoparticles can be internalized into cells and exhibit no cytotoxic effects, showing that such novel biocompatible core/shell structures can potentially be used as in vivo bioimaging labels. This facile one‐pot polymerization and encapsulation technique may provide a useful tool to synthesize other core/shell particles that have potential application in biotechnology.

Antimicrobial Activity of Silver Nanocrystals Encapsulated in Mesoporous Silica Nanoparticles

“…Gold, semiconductor, and iron oxide nanocrystals can be incorporated within mesoporous silica nanoparticles to create a yolk/shell architecture without collapsing the mesostructure. [24][25][26][27] In comparison to the traditional coating of inorganic nanocrystals with nonporous silica or polymer, [28][29][30][31][32] the mesoporous silica shell offers the advantage of being able to store molecules or to slowly release the encapsulated inorganic materials. [33,34] Based on the works by Trewyn et al in synthesizing mesoporous nanoparticles that release bactericidal cationic surfactants, [35] and Jiang et al in preparing mesoporous nanoparticles that slowly release trapped salt crystals, [34] we have developed a system in which the antimicrobial materials are strongly embedded within the nanoparticles.…”

Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport

“…Nano Res. method through ammonia-catalysed hydrolysis of tetraethylorthosilicate (TEOS) in an aqueous basic solution [30]. This mesoporous silica layer provided monodispersity based on framed structures where polymerisation of polyaniline (PANI) could occur.…”

Fluorescent glutathione probe based on MnO 2 -phenol formaldehyde resin nanocomposite

“…Recently, Yu's group has reported a one-step hydromental approach of green luminescent phenol formaldehyde resin (PFR) nanoparticles with the characteristic of stable luminescence and good monodispersibility (Guo et al, 2008;Yang et al, 2012a;Yang et al, 2012b). Moreover, PFR nanoparticles are low toxicity in water with controllable size.…”