Biocompatibility of resin composites subcutaneously implanted in rats with experimentally induced arthritis

Αναγνώστου, Μαρία; Chatzigianni, Emmy; Doucoudakis, S.; Potamianou, A.; Tesseromatis, C.

doi:10.1016/j.dental.2008.09.012

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…These effects have been extensively reviewed in the literature [16–21]. On the other hand, a significant amount of scientific effort has been focused during the past few years by several research groups in the world on the determination of the molecular mechanisms underlying the dental composites’ toxicological effects (cytotoxicity and genotoxicity).…”

Section: Introductionmentioning

confidence: 99%

Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials

Bakopoulou

Papadopoulos

Garefis

2009

IJMS

172

149

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Resin-based dental restorative materials are extensively used today in dentistry. However, significant concerns still remain regarding their biocompatibility. For this reason, significant scientific effort has been focused on the determination of the molecular toxicology of substances released by these biomaterials, using several tools for risk assessment, including exposure assessment, hazard identification and dose-response analysis. These studies have shown that substances released by these materials can cause significant cytotoxic and genotoxic effects, leading to irreversible disturbance of basic cellular functions. The aim of this article is to review current knowledge related to dental composites’ molecular toxicology and to give implications for possible improvements concerning their biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials

Bakopoulou

Papadopoulos

Garefis

2009

IJMS

172

149

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“…30 Bu durumun; lokal veya sistemik toksisite, alerjik ve östrojenik etkiler gibi biyolojik reaksiyonlara sebep olabildiği belirtilmiştir. 24,[31][32][33][34] Oral dokular ile restorasyonlar arasındaki direkt etkileşim biyouyumluluğu etkileyebilmektedir. Plak ve jinjival indekslerde olduğu gibi sondlanabilen cep derinliğinin de beş-altı yıllık direkt kompozit rezin restorasyonlara komşu bölgelerde yüksek bulunduğu bildirilmiştir.…”

Section: Discussionunclassified

Investigation of the Cytotoxic Effect of Composite Materials on Gingival Fibroblast Cells

Taghizadehghalehjoughi¹,

Ok²,

Kamalak³

2019

Turkiye Klinikleri J Dental Sci

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“…While in some studies the specimens were directly implanted into subcutaneous connective tissues [4], in the others they were placed in tubes and then implanted [3, 5]. In this study 2 mm thick resin composite discs were used to mimic clinical conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Researches conducting on biocompatibility of resin composites showed the accepted biocompatibility of these materials [3, 5]. Also, the other studies on cytotoxicity of resin composites cured with different curing units and different light-emitting methods have shown various outcomes.…”

Section: Introductionmentioning

confidence: 99%

Reaction of Rat Subcutaneous Connective Tissue to Resin Composites Polymerized with Different Light Curing Units and Different Lightening Methods

Feiz

Zavareh

Razavi³

et al. 2012

International Journal of Dentistry

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The aim of the study was to determine and compare the reaction of rat subcutaneous connective tissue to resin composites polymerized with different lights curing and lightening methods. In this in vivo study, 20 mature Wister Albino rats were used. The composite discs, 4 mm in diameter and 2 mm thick, were cured by QTH or LED light curing units with 4 different lightning methods (full power QTH, full power LED, pulse LED, and ramp LED). Five resin composite discs were implanted in each rat, so that 4 of 5 discs for implantation of cured composite discs differently and central one as control without implantation. After sacrificing at 7, 14, 30, and 60 days the inflammatory grade, fibrosis, and necrosis were determined. Freedman and Cochran tests were used to analyze the data using SPSS software ver. 15. The results of the study showed significant differences in inflammation grade and fibrosis among control group and 4 experimental groups at day 14 (P < 0.05). In necrosis, there was no significant difference among 4 groups in different times (P > 0.05). In conclusion, neither the type of light curing units (LED or QTH) nor the lightening methods can affect the grade of inflammatory reaction.

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Biocompatibility of resin composites subcutaneously implanted in rats with experimentally induced arthritis

Cited by 7 publications

References 19 publications

Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials

Molecular Toxicology of Substances Released from Resin–Based Dental Restorative Materials

Investigation of the Cytotoxic Effect of Composite Materials on Gingival Fibroblast Cells

Reaction of Rat Subcutaneous Connective Tissue to Resin Composites Polymerized with Different Light Curing Units and Different Lightening Methods

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