Biocompatibility of resin‐based materials used as pulp‐capping agents

Abstract

Both experimental pulp-capping agents allowed pulpal healing characterized by cell-rich fibrodentine and tertiary dentine deposition as well as calcified barrier formation.

Effects of light-curing time on the cytotoxicity of a restorative composite resin on odontoblast-like cells

“…In the present study, a significant reduction in the cytotoxic effects occurred when the composite resin was light-activated for 60 s (G4) and the results were similar to those of the control group (G5). Costa, et al 6 (2003) suggested that the cytotoxicity of the dental materials is inversely proportional to the light-curing time, which is in accordance with our results when a 60 s exposure to the light source was used (G4). These outcomes also agree with those of Caughmann, et al 3 (1991) who evaluated the cytotoxicity of three composite resins subjected to different light-curing times (15, 30 and 45 s) and correlated the results with the monomer conversion rate.…”

“…No statistical significance was found between these curing times. These results are not consistent with those of Costa, et al 6 (2003), who concluded that the composite resin light-cured for 20 s was more cytotoxic to MDPC-23 cells than the experimental material light-cured for 40 s, with a reduction in cell metabolism by 40.1% and 24.5%, respectively. These different findings may be due to the fact that Costa, et al.…”

Effects of light-curing time on the cytotoxicity of a restorative composite resin on odontoblast-like cells

“…In the present study, a significant reduction in the cytotoxic effects occurred when the composite resin was light-activated for 60 s (G4) and the results were similar to those of the control group (G5). Costa, et al 6 (2003) suggested that the cytotoxicity of the dental materials is inversely proportional to the light-curing time, which is in accordance with our results when a 60 s exposure to the light source was used (G4). These outcomes also agree with those of Caughmann, et al 3 (1991) who evaluated the cytotoxicity of three composite resins subjected to different light-curing times (15, 30 and 45 s) and correlated the results with the monomer conversion rate.…”

“…No statistical significance was found between these curing times. These results are not consistent with those of Costa, et al 6 (2003), who concluded that the composite resin light-cured for 20 s was more cytotoxic to MDPC-23 cells than the experimental material light-cured for 40 s, with a reduction in cell metabolism by 40.1% and 24.5%, respectively. These different findings may be due to the fact that Costa, et al.…”

Long-Term Evaluation of Pulp Vitality Preservation in Direct and Indirect Pulp Capping: A Retrospective Clinical Study

“…In the current trial, the resin-based glass ionomer exhibited a lower probability of maintaining pulp exposure vitality compared with other materials, supporting some previous findings [34][35][36]. Even if fluoride has been claimed to be beneficial due to the formation of fluoride-apatite crystals and remineralization [10,37], the diffusion of glass ionomer components into the pulp may result in long-lasting inflammation mediated by macrophages and giant cells that impairs healing and dentinal bridge formation [34][35][36][37].…”

Real–time Cell Analysis of Cytotoxicity of Dental Bonding Agents on Human Dental Pulp Cells

“…30 In contrast to this, high molecular-weighted hydrophobic materials like BIS-GMA, however, are released in very low amounts and can penetrate into the membranes at a rather low rate. 18 This view seems to partially support our study. In our study; among the two self-etch bonding agents containing TEGDMA (M.W.= 286 g/mol), which we examined, "Shofu Beautibond ® " without containing HEMA was found to be the least cytotoxic.…”

Effects of light-curing time on the cytotoxicity of a restorative composite resin on odontoblast-like cells

“…In the present study, a significant reduction in the cytotoxic effects occurred when the composite resin was light-activated for 60 s (G4) and the results were similar to those of the control group (G5). Costa, et al 6 (2003) suggested that the cytotoxicity of the dental materials is inversely proportional to the light-curing time, which is in accordance with our results when a 60 s exposure to the light source was used (G4). These outcomes also agree with those of Caughmann, et al 3 (1991) who evaluated the cytotoxicity of three composite resins subjected to different light-curing times (15, 30 and 45 s) and correlated the results with the monomer conversion rate.…”

“…No statistical significance was found between these curing times. These results are not consistent with those of Costa, et al 6 (2003), who concluded that the composite resin light-cured for 20 s was more cytotoxic to MDPC-23 cells than the experimental material light-cured for 40 s, with a reduction in cell metabolism by 40.1% and 24.5%, respectively. These different findings may be due to the fact that Costa, et al.…”

Long-Term Evaluation of Pulp Vitality Preservation in Direct and Indirect Pulp Capping: A Retrospective Clinical Study

“…In the current trial, the resin-based glass ionomer exhibited a lower probability of maintaining pulp exposure vitality compared with other materials, supporting some previous findings [34][35][36]. Even if fluoride has been claimed to be beneficial due to the formation of fluoride-apatite crystals and remineralization [10,37], the diffusion of glass ionomer components into the pulp may result in long-lasting inflammation mediated by macrophages and giant cells that impairs healing and dentinal bridge formation [34][35][36][37].…”

Real–time Cell Analysis of Cytotoxicity of Dental Bonding Agents on Human Dental Pulp Cells

“…30 In contrast to this, high molecular-weighted hydrophobic materials like BIS-GMA, however, are released in very low amounts and can penetrate into the membranes at a rather low rate. 18 This view seems to partially support our study. In our study; among the two self-etch bonding agents containing TEGDMA (M.W.= 286 g/mol), which we examined, "Shofu Beautibond ® " without containing HEMA was found to be the least cytotoxic.…”

Effects of light-curing time on the cytotoxicity of a restorative composite resin on odontoblast-like cells

“…In the present study, a significant reduction in the cytotoxic effects occurred when the composite resin was light-activated for 60 s (G4) and the results were similar to those of the control group (G5). Costa, et al 6 (2003) suggested that the cytotoxicity of the dental materials is inversely proportional to the light-curing time, which is in accordance with our results when a 60 s exposure to the light source was used (G4). These outcomes also agree with those of Caughmann, et al 3 (1991) who evaluated the cytotoxicity of three composite resins subjected to different light-curing times (15, 30 and 45 s) and correlated the results with the monomer conversion rate.…”

“…No statistical significance was found between these curing times. These results are not consistent with those of Costa, et al 6 (2003), who concluded that the composite resin light-cured for 20 s was more cytotoxic to MDPC-23 cells than the experimental material light-cured for 40 s, with a reduction in cell metabolism by 40.1% and 24.5%, respectively. These different findings may be due to the fact that Costa, et al.…”

Long-Term Evaluation of Pulp Vitality Preservation in Direct and Indirect Pulp Capping: A Retrospective Clinical Study

“…In the current trial, the resin-based glass ionomer exhibited a lower probability of maintaining pulp exposure vitality compared with other materials, supporting some previous findings [34][35][36]. Even if fluoride has been claimed to be beneficial due to the formation of fluoride-apatite crystals and remineralization [10,37], the diffusion of glass ionomer components into the pulp may result in long-lasting inflammation mediated by macrophages and giant cells that impairs healing and dentinal bridge formation [34][35][36][37].…”

Real–time Cell Analysis of Cytotoxicity of Dental Bonding Agents on Human Dental Pulp Cells

“…30 In contrast to this, high molecular-weighted hydrophobic materials like BIS-GMA, however, are released in very low amounts and can penetrate into the membranes at a rather low rate. 18 This view seems to partially support our study. In our study; among the two self-etch bonding agents containing TEGDMA (M.W.= 286 g/mol), which we examined, "Shofu Beautibond ® " without containing HEMA was found to be the least cytotoxic.…”