Biocompatibility of acellular dermal matrix graft evaluated in culture of murine macrophages

Vendramini, Ana Paula; Melo, Rafaela Fernanda; Marcantonio, Rosemary Adriana Chiérici; Carlos, Iracilda Zeppone

doi:10.1590/s1678-77572006000200001

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…The release of NO and H2O2 as positive control showed statistically significantly higher values in the LPS group than in the ADM group. In the study mentioned, it was observed that serum did not show any significant difference compared with the ADM group, indicating that it did not have a therapeutic effect in the study context [109].…”

Section: Acellular Dermal Matricesmentioning

confidence: 86%

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Haller,

Sander,

Nischwitz

et al. 2023

Preprint

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Although a slight imbalance between oxidative and antioxidative mediators is part of normal physiology that enables cell aging and the removal of dead cells, burns disturb this equilibrium locally and systemically. Topical burn dressings may attenuate local and systemic oxidative stress and positively influence the post-burn clinical course. This review integrated knowledge regarding the impact of burn dressings on oxidative stress. Using keywords and in-text searches, literature was identified from PubMed, Google Scholar, and Google articles, and studies on local or topical applications of wound dressings and associated oxidative stress were selected. As im-balances between oxidative mediators and antioxidative agents significantly contribute to organ dysfunction and healing disturbance, we investigated oxidative stress on organs, metabolic changes, clinical results, and oxidative parameters influenced by applied dressings. We found positive local and systemic effects of external burn dressings in laboratory and animal tests; however, such studies were rare in humans. Nevertheless, we identified successful cases of semi-occlusive, occlusive, and biologically active dressings that reduce oxidative stress in hu-man burns. In particular, we highlight promising clinical and laboratory results from lac-tate-releasing dressings. Our review provides an invaluable resource for future development and clinical applications of burn dressings.

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Section: Acellular Dermal Matricesmentioning

confidence: 86%

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Haller,

Sander,

Nischwitz

et al. 2023

Preprint

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High-Frequency Ultrasonic Imaging of Growth and Development in Manufactured Engineered Oral Mucosal Tissue Surfaces

Winterroth

Kato

Kuo

et al. 2014

Ultrasound in Medicine & Biology

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This study uses high-resolution ultrasound to examine growth and development of engineered oral mucosal tissues manufactured under aseptic conditions. The specimens are a commercially available natural tissue scaffold, AlloDerm® and oral keratinocytes seeded onto AlloDerm® to form a ex vivo produced oral mucosal equivalent (EVPOME) suitable for intraoral grafting. The seeded cells produce a keratinized protective upper layer which smooth’s out any remaining surface irregularities on the underlying AlloDerm®. Two-dimensional acoustic imaging of unseeded AlloDerm® and developing EVPOMEs were performed at each consecutive day of their growth and development, requiring imaging each of the tissue specimens under aseptic conditions (total time from seeding to maturation: 11 days). Ultrasonic monitoring offers us an ability to determine the constituents in the EVPOME that are responsible for changes in its mechanical behavior during the manufacturing process. Ultrasonic monitoring affords us an opportunity to non-invasively assess, in real time, tissue engineered constructs prior to release for use in patient care.

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Effects of a probiotic soy product and physical exercise on formation of pre-neoplastic lesions in rat colons in a short-term model of carcinogenic

Silva

Sivieri

Rossi

2009

Journal of the International Society of Sports Nutrition

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Purpose: In this study the influence of moderate or intense physical exercise, alone or in combination with the consumption of a soya product fermented with Enterococcus faecium, on the development of colon cancer induced chemically in rats with 1,2-dimethylhydrazine (DMH), was investigated.Methods: Eighty male Wistar SPF rats were randomly allocated to 8 groups (n = 10). One week after the start of the program of product ingestion and/or physical activity, all animals except the controls (group I) were injected subcutaneously with 50 mg/kg b.w. of 1,2-dimethylhydrazine (DMH). This procedure was repeated at the end of the second week. At the end of the 6-week experiment, all the animals were euthanized; the colons were removed and numbers of ACF was estimated.Results: Twenty-four days after the induction of pre-neoplastic lesions, it was evident that the formation of ACF was not significantly reduced by the ingestion of the fermented product, by intense or moderate physical activity or by a combination of these factors, in comparison with the positive control group of rats (p < 0.05). On the other hand, the performance of intense exercise, on its own, increased the number of ACF. Conclusion:The results reported in this article show that consumption of the fermented soy product described here and the practice of physical exercise (intense or moderate) were incapable, separately or combined, of inhibiting the formation of ACF in DMH-induced rats. The intense physical exercise led to an increased number of foci in the colons of these rats and, probably, to greater susceptibility to colorectal cancer.

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Biocompatibility of acellular dermal matrix graft evaluated in culture of murine macrophages

Cited by 3 publications

References 19 publications

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

Shielding Burn Patients from Oxidative Stress: The Therapeutic Potential of Antioxidant Membranes

High-Frequency Ultrasonic Imaging of Growth and Development in Manufactured Engineered Oral Mucosal Tissue Surfaces

Effects of a probiotic soy product and physical exercise on formation of pre-neoplastic lesions in rat colons in a short-term model of carcinogenic

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