Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles

Elmowafy, Enas; Tiboni, Mattia; Soliman, Mahmoud E.

doi:10.1007/s40005-019-00439-x

Cited by 392 publications

(234 citation statements)

References 160 publications

(173 reference statements)

Supporting

Mentioning

208

Contrasting

Unclassified

Order By: Relevance

“…Once the monomers are formed, they are eliminated by physiological pathways. Lactic acid enters the tricarboxylic acid cycle and is metabolized and eliminated in carbon dioxide and water, while glycolic acid is excreted unchanged by the kidneys or metabolized by the tricarboxylic acid cycle (Jain et al 1998;Sinha and Trehan 2003;Elmowafy et al 2019).…”

Section: Polymer Featuresmentioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Blasi

2019

J. Pharm. Investig.

163

View full text Add to dashboard Cite

Background Poly(glycolic acid), poly(lactic acid) and poly(lactic-co-glycolic acid) were approved by the United States Food and Drug Administration (FDA) in the 1970s as materials for the manufacturing of bioresorbable surgical sutures, but soon became the reference materials for the preparation of sustained release formulations, especially injectable microparticles. Since the 1986 approval of Decapeptyl ® SR, the first product based on PLGA microspheres, more than 15 such products have been approved for clinical use. Area covered This article highlights the key steps that brought to the development of injectable poly(lactic acid)/poly(lacticco-glycolic acid) microparticles for the sustained release of active pharmaceutical ingredients. After a brief history of some pioneering works that opened the field of controlled drug delivery, the key steps that led to the development of these polymers and the approval of the first microparticle-based medicinal products are reviewed. Finally, the general characteristics of these polymers are described and the classical preparation method is explained. Expert opinion Poly(lactic acid)/poly(lactic-co-glycolic acid) microparticles are among the most successful drug delivery systems. The recent approval of new medicinal products based on PLGA microspheres is the proof that pharmaceutical companies have continued to exploit this drug delivery technology. The possible development of generics and the continuous discovery of therapeutic peptides will hopefully further the success of microsphere technology.

show abstract

Section: Polymer Featuresmentioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Blasi

2019

J. Pharm. Investig.

163

View full text Add to dashboard Cite

show abstract

“…Biocompatible scaffolds have to support normal cellular activity (cells attachment, migration, proliferation, differentiation) without any toxic effects to the host tissue [148]. Several research projects have been carried out about the biocompatibility of both natural and synthetic electrospun polymers [149][150][151]. Among the first, chitosan [152], collagen [153], gelatin [154] or cellulose [155] have been widely explored in tissue engineering due to their bio-based origin, renewability, biocompatibility and biodegradability.…”

Section: Advanced Smart Propertiesmentioning

confidence: 99%

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

et al. 2020

View full text Add to dashboard Cite

In the last few decades, the development of new electrospun materials with different morphologies and advanced multifunctional properties are strongly consolidated. There are several reviews that describe the processing, use and characterization of electrospun nanocomposites, however, based on our knowledge, no review on electrospun nanocomposites reinforced with nanoparticles (NPs) based on magnesium, Mg-based NPs, are reported. Therefore, in the present review, we focus attention on the fabrication of these promising electrospun materials and their potential applications. Firstly, the electrospinning technique and its main processing window-parameters are described, as well as some post-processing methods used to obtain Mg-based materials. Then, the applications of Mg-based electrospun nanocomposites in different fields are pointed out, thus taking into account the current trend in developing inorganic-organic nanocomposites to gradually satisfy the challenges that the industry generates. Mg-based electrospun nanocomposites are becoming an attractive field of research for environmental remediation (waste-water cleaning and air filtration) as well as for novel technical textiles. However, the mayor application of Mg-based electrospun materials is in the biomedical field, as pointed out. Therefore, this review aims to clarify the tendency in using electrospinning technique and Mg-based nanoparticles to huge development at industrial level in the near future.

show abstract

“…Chrysin-loaded poly (d, l-lactic-co-glycolic acid) PLGA and polyvinyl alcohol have been effectively developed for targeting cancer cells [79,80]. PLGA has been successfully used biocompatible and biodegradable polymer because it is converted to two secondary metabolites, glycolic acid, and lactic acid (both of these molecules are metabolized through the Krebs cycle, which decreases systemic toxicity and enhances therapeutic benefits for efficient drug delivery [81]). For example, chrysin-curcumin in PLGA-PEG (polyethylene glycol) down-regulates cyclin D1 expression and suppresses the proliferation of breast cancer cells [82,83].…”

Section: Modified Chrysinmentioning

confidence: 99%

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Atiq

Parhar

2020

Molecules

View full text Add to dashboard Cite

Clinically, gliomas are classified into four grades, with grade IV glioblastoma multiforme being the most malignant and deadly, which accounts for 50% of all gliomas. Characteristically, glioblastoma involves the aggressive proliferation of cells and invasion of normal brain tissue, outcomes as poor patient prognosis. With the current standard therapy of glioblastoma; surgical resection and radiotherapy followed by adjuvant chemotherapy with temozolomide, it remains fatal, because of the development of drug resistance, tumor recurrence, and metastasis. Therefore, the need for the effective therapeutic option for glioblastoma remains elusive. Previous studies have demonstrated the chemopreventive role of naturally occurring pharmacological agents through preventing or reversing the initiation phase of carcinogenesis or arresting the cancer progression phase. In this review, we discuss the role of natural phytochemicals in the amelioration of glioblastoma, with the aim to improve therapeutic outcomes, and minimize the adverse side effects to improve patient’s prognosis and enhancing their quality of life.

show abstract

Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles

Cited by 392 publications

References 160 publications

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview

Potential Applications of Magnesium-Based Polymeric Nanocomposites Obtained by Electrospinning Technique

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Contact Info

Product

Resources

About