Biocidal potential of biosynthesized silver nanoparticles against fungal threats

Abstract

Microbes are the major cause for the hospitalacquired infections which lead to prolonged illness, disability or even death. The increasing microbial resistance calls for the search for newer drugs. Evolving nanotechnology in drug delivery produces drug action in lesser amounts and with several times more potency. In the present work, we have synthesized AgNPs using the aqueous extracts of Amaranthus dubius, Amaranthus polygonoides, Alternanthera sessilis, Portulaca oleracea, Pisonia grandis, and Kedrostis foetidissima. Sonication method yielded a facile and rapid method of biogenic synthesis of nanosilver. The TEM images revealed the synthesized AgNPs to be of size ranging between 6 and 23 nm without agglomeration. Antifungal activity of the synthesized AgNPs against C. albicans and S. cerevisiae carried out by agar well diffusion method showed good zones of inhibition disclosing the antifungal potential of the biogenic silver nanoparticles.

Biologically synthesized silver nanoparticles by aqueous extract of Satureja intermedia C.A. Mey and the evaluation of total phenolic and flavonoid contents and antioxidant activity

“…Previously, noble nanoparticles were synthesized by using various plant materials like: Mentha piperita [10]; Ipomoea pescaprae [11]; Ocimum sanctum [12]; Amaranthus dubius [13] etc. The exact mechanism of SNPs synthesis mediated by plant extracts is not yet fully understood.…”

In Vitro Evaluation of Antimicrobial Activity and Cytotoxicity of Different Nanobiotics Targeting Multidrug Resistant and Biofilm Forming Staphylococci

“…There are challenges facing the application of this strategy for clinical use including the interaction of nanobiotics with cells, tissues, and organs [34, 44]. Theoretically, nanoparticles are retained much longer in the body than antibiotics, which could be beneficial for achieving sustained therapeutic effects [45, 46].…”

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“…This fact was reaffirmed by the toxicity study of a polyherbal formulation 9 of which Pisonia grandis constituted one-fifth of the concentration of the formulation that showed no mortality even at the dosage of 1000mg/kg body weight. Yet another biherbal formulation 33 38 exhibited significant antifungal activity 39 and found to be useful in biomedical imaging 40 . The zinc oxide (ZnO) and magnesium oxide (MgO) nanoparticles from leaf extract of Pisonia grandis were found to exhibit high anti-bacterial activity against M. luteus and K. pneumonia and a higher anti-fungal activity against C. albicans strain.…”