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Cited by 140 publications
(55 citation statements)
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“…On this basis Peters (3) and Martius (4) proposed that the inhibitory substance was a fluorotricarboxylic acid. Subsequently it was shown that 2-fluorocitrate is indeed produced metabolically via the citrate synthase reaction (5) and that in the presence of this substance the enzyme aconitase is inhibited (6). Aconitase catalyzes the conversion of citrate to isocitrate (Iso) via the obligatory intermediate cis-aconitate (Scheme I).…”
mentioning
confidence: 99%
“…On this basis Peters (3) and Martius (4) proposed that the inhibitory substance was a fluorotricarboxylic acid. Subsequently it was shown that 2-fluorocitrate is indeed produced metabolically via the citrate synthase reaction (5) and that in the presence of this substance the enzyme aconitase is inhibited (6). Aconitase catalyzes the conversion of citrate to isocitrate (Iso) via the obligatory intermediate cis-aconitate (Scheme I).…”
mentioning
confidence: 99%
“…Citrate synthase (CS) performs the first reaction in the citric acid cycle: the formation of citrate from oxaloacetate and acetate in the form of acetyl-CoA. When fluoroacetyl-CoA (from fluoroacetate) is used as a substrate instead of acetyl-CoA, 2-fluorocitrate is formed, [2] which inhibits aconitase, [3,4] the next enzyme in the citric acid cycle. This process is responsible for the lethal toxicity of fluoroacetate to humans and other mammals.…”
mentioning
confidence: 99%
“…Labeling of acetate with 18 F is a potential means to make possible the clinical use of radiolabeled acetate (39,46). Fluoroacetate is the toxic ingredient of the South African poison plant Dichapetalum chymosum and of other Dichapetalum plants (47). Fluoroacetate and its toxic metabolite fluorocitrate inhibit aconitase in brain tissue and are preferentially taken up by glial cells and lead to inhibition of the glial tricarboxylic acid cycle (TCA cycle).…”
Section: Discussionmentioning
confidence: 99%