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“…Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19]. The pharmacological effect of orotic acid is thought to rely on the activation of anaerobic metabolism through maintenance of glycogen stores, significant increase in protein synthesis, and nucleotide metabolism [20,21].…”
Section: Introductionmentioning
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“…Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19]. The pharmacological effect of orotic acid is thought to rely on the activation of anaerobic metabolism through maintenance of glycogen stores, significant increase in protein synthesis, and nucleotide metabolism [20,21].…”
Section: Introductionmentioning