Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

Volna, Jana; Kemlink, David; Kalousová, Marta; Vávrová, Jana; Majerová, Veronika; Mestek, Oto; Švarcová, Jana; Šonka, Karel; Zima, Tomáš

doi:10.12659/msm.881935

Cited by 49 publications

(29 citation statements)

References 38 publications

(39 reference statements)

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“…In agreement with Tazaki, Ye, Feng and Volna [9,32,35,41], we observed in the whole group of OSAS subjects a positive correlation between MMP-9 and AHI, and between MMP-9 and ODI and also a negative correlation between MMP-9 and mSO 2 . In this study no significant correlation among MMP-2, TIMP-1, TIMP-2 and polysomnographic parameters was demonstrated.…”

Section: Discussionsupporting

confidence: 92%

“…As well as the hypoxic stress induced by OSAS promotes the synthesis of inflammatory mediators [31,35] involved in the development and the progression of the atherosclerotic disease, similarly the hypoxic stress seems to be able to modify the pattern of MMPs and TIMPs itself.…”

Section: Discussionmentioning

confidence: 99%

“…Differently, in children with OSAS no correlation between MMP-9 levels and OSAS severity has been observed [14]. Volná et al [35] evaluated both the gelatinases in OSAS subjects and they observed a significant correlation only between MMP-9 and some polysomnographic parameters, such as oxygen desaturation index (ODI) and mean oxygen saturation. Chuang et al [3] studied plasma levels of MMP-1, -2, -3, and -9 and of TIMP-1 and also plasma MMP-9 activity in OSAS subjects subdivided according to the severity of the disease; they found only elevated concentration and activity of MMP-9, especially after sleep.…”

Section: Introductionmentioning

confidence: 98%

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Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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Abstract. Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into two subgroups according to the apnea/hypopnea index (AHI): Low (L = 21 subjects with AHI <30) and High (H = 27 subjects with AHI >30). We measured plasma concentration of the gelatinases and their inhibitors using ELISA kits. We observed a significant increase in plasma concentration of MMP-9, MMP-2, TIMP-1 and TIMP-2 in the entire group of OSAS subjects and in the two subgroups, with higher levels in the H in comparison with the L subgroup. In the whole group of OSAS subjects we also noted a significant decrease in MMP-9/TIMP-1 ratio in comparison with normal controls. Only MMP-9 was significantly correlated with the severity of the disease, expressed as AHI, with the oxygen desaturation index and also with the mean oxygen saturation. MMPs pattern is altered in OSAS and significantly influenced by the severity of the disease; it probably contributes to the vascular remodeling that leads to the atherosclerotic disease and cardiovascular complications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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“…These abnormal respiratory events lead to hypoxia and reoxygenation cycles which eventually results in oxidative stress. Oxidative stress gives rise the production of reactive oxygen species which may regulate MMP levels in various cells and in vitro systems (21). MMP-9 is suggested to be a strong predictor of oxidative stress in OSA patients (21).…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress gives rise the production of reactive oxygen species which may regulate MMP levels in various cells and in vitro systems (21). MMP-9 is suggested to be a strong predictor of oxidative stress in OSA patients (21). Thus, reactive oxygen species produced during oxidative stress may contribute to elevated levels and activity of MMP-9 in patients with OSAS.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-9 Level and Gene Polymorphism in Sleep DisorderedBreathingPatientswithorwithout CardiovascularDisorders

Yüksel

Okur²,

Öğünç

et al. 2013

Balkan Med J

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IntroductionIncreased cardiovascular morbidity and mortality are wellknown consequences of obstructive sleep apnea syndrome (OSAS) (1,2). Epidemiological data demonstrated definite associations between OSAS and cardiovascular disorders such as hypertension, ischemic heart disease, congestive heart failure, and stroke (3). Clinical and experimental studies yielded convincing evidence that various acute (negative intrathoracic pressure, hypoxia and arousals) and chronic (sympathetic nervous system activity, hormonal alterations) factors resulting from repetitive abnormal respiratory events during sleep may play key roles in the development of cardiovascular disorders during the course of OSAS. However, the pathophysiological link between sleep apnea syndrome and cardiovascular disorders is not clear. Recently, matrix metalloproteinases have become an important focus of research in the pathogenesis of atherosclerotic cardiovascular diseases and hypertension (4).Matrix metalloproteinase-9 (MMP-9) is a proteolytic enzyme which contributes to extracellular matrix degradation and vascular remodeling (5). MMP-9 shows proteolytic activity on type IV collagen which forms a basement membrane under the endothelium of all blood vessels. Studies have shown that certain cardiovascular disorders such as coronary artery disease, arterial stiffness, atherosclerosis and hypertension may be associated with MMP-9 polymorphism and serum levels (4, 6, 7). There is also an association between increased serum levels and activity of MMP-9 and severity of OSAS (8, 9). Systemic inflammatory markers such as C-reactive protein, interleukin-6 (IL-6) and TNF-α were found to be positively correlated with MMP-9 activity in patients with OSAS (8, 9). However, there are no published studies reporting MMP-9 levels in OSAS patients with or without cardiovascular disorders who carry different alleles of MMP-9 gene polymorphism. In addition, although it has been shown that genetic polymorphism of MMP-9 does not necessarily affect the plasma activity in healthy subjects (10), the relationship of MMP-9 polymorphism and serum MMP-9 level was not assessed in sleep apnea patients.In this study, we aimed to investigate MMP-9 polymorphism and level in OSAS patients with or without cardiovascular (CV) disorders. We also aimed to yield further evidence for the lack of association between MMP-9 polymorphism and serum MMP-9 level. We hypothesized that MMP-9 level is higher in CV-positive (CV-P) OSAS patients with respect to CV-negative (CV-N) OSAS patients. ABSTRACTObjective: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. We aimed to investigate the matrix metalloproteinase-9 (MMP-9) level and MMP-9 gene polymorphism in sleep apnea patients with or without cardiovascular disease.Study Design: Case-control study.Material and Methods: Two hundred nine patients [Mean age (±SD), 47 (±12) yrs; M/F, 170/39] diagnosed with sleep-disordered breathing were included in the study. Serum MMP-9 level was performe...

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Free Radicals and Sleep Apnea

Kanlı́kama

Baysal

2015

Free Radicals in ENT Pathology

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Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

Cited by 49 publications

References 38 publications

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Matrix Metalloproteinase-9 Level and Gene Polymorphism in Sleep DisorderedBreathingPatientswithorwithout CardiovascularDisorders

Free Radicals and Sleep Apnea

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