Biochemical markers of cerebrovascular injury in sleep apnoea syndrome

Jordan, Wolfgang; Hagedohm, J; Wiltfang, Jens; Laier-Groeneveld, G; Tumani, Hayrettin; Rodenbeck, Andrea; Rüther, E; Hajak, Göran

doi:10.1183/09031936.02.00862001

Cited by 21 publications

(20 citation statements)

References 39 publications

(50 reference statements)

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“…Another limitation is that neuronal injury caused by ischemia during CEA might be too small to cause a measurable increase of NfH SMI35 in peripheral-venous blood. This was also suggested for other biomarkers of subtle brain ischemia such as neuron-specific enolase, S100B and b-trace protein [20]. Also, DWI is a sensitive method for confirming brain ischemia but detection of every lesion may have been missed since it was applied within 2 days after the intervention.…”

Section: Discussionmentioning

confidence: 95%

The Value of the Serum Neurofilament Protein Heavy Chain as a Biomarker for Peri-operative Brain Injury After Carotid Endarterectomy

Sellner

Petzold²,

Sadikovic

et al. 2009

Neurochem Res

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This prospective study examined the value of serum neurofilament protein levels for detecting peri-operative brain damage following carotid endarterectomy. An ELISA was used for quantification of neurofilament protein heavy chain (NfH(SMI35)) levels from patients undergoing endarterectomy for symptomatic (n = 17) and asymptomatic high-grade internal carotid artery stenosis (n = 30). All patients underwent diffusion-weighted brain imaging before and after the procedure. NfH(SMI35) levels were significantly higher in patients with a symptomatic carotid artery stenosis (0.131 ng/ml) if compared to asymptomatic patients (0.055 ng/ml, P = 0.01). However, serum NfH(SMI35) levels were not related to signs of brain ischemia on routine brain imaging techniques. Our pilot data suggests that raised NfH(SMI35) serum levels in patients with symptomatic carotid artery disease may be a sensitive biomarker for diffuse ischemic damage to the CNS. We conclude that NfH(SMI35) failed to qualify as a biomarker for peri-operative brain injury in CEA and factors that may have compromised the validation of this biomarker are discussed and need to be taken into account for the design of further studies.

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Section: Discussionmentioning

confidence: 95%

The Value of the Serum Neurofilament Protein Heavy Chain as a Biomarker for Peri-operative Brain Injury After Carotid Endarterectomy

Sellner

Petzold²,

Sadikovic

et al. 2009

Neurochem Res

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“…31,32 Higher serum BTP values have been associated with lower serum albumin values and more severe sleep apnea, suggesting a possible link with vascular or endothelial dysfunction. [33][34][35][36] The Mild and Moderate Kidney Disease study examined the association of BTP adjusted for measured GFR with CKD progression in 177 patients (29 kidney failure outcomes). 37 The results showed a HR of 2.80 for BTP after adjustment for age, sex, measured GFR, and proteinuria, consistent with the hypothesis that non-GFR determinants of BTP may be associated with kidney disease progression.…”

Section: Discussionmentioning

confidence: 99%

Filtration Markers May Have Prognostic Value Independent of Glomerular Filtration Rate

Tangri

Inker

Tighiouart

et al. 2012

Journal of the American Society of Nephrology

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Serum levels of creatinine, cystatin C, or b trace protein allow estimation of GFR, but whether these markers contribute additional prognostic information beyond that reflected in GFR is unknown. Here, we analyzed data from the Modification of Diet in Renal Disease study, which provided baseline levels of these markers for 816 participants with a median follow-up of 16.6 years. We examined associations between the reciprocals of these filtration markers and 125 I iothalamate GFR, expressed per SD, with kidney failure and mortality. In univariate analysis, lower GFR and higher levels of each filtration marker associated with a higher risk for all outcomes. After adjustment for GFR in a Cox proportional hazards model, higher creatinine associated with a higher risk for kidney failure but a lower risk for all-cause mortality. Higher cystatin C and b trace protein associated with a higher risk for both kidney failure and all-cause mortality. In models including either cystatin C or b trace protein, the association of GFR with all-cause mortality was no longer significant after the addition of the filtration marker, suggesting the possibility of multicollinearity. In summary, after adjustment for GFR, levels of creatinine, cystatin C, and b trace protein, each remained directly associated with kidney failure but differed with respect to their associations with mortality. These differences may be a result of non-GFR-related associations of filtration markers, residual confounding by GFR, or collinearity between the filtration markers and GFR. b trace protein and cystatin C seem to provide more consistent prognostic information than creatinine.

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“…Jordan et al 27 have also investigated biochemical markers, including NSE, S100B and beta-trace proteins, of brain damage in OSAS patients just before and after sleep. However, their results were showed that no difference between controls and patients.…”

Section: Discussionmentioning

confidence: 99%