Biochemical markers of cerebrospinal ischemia after repair of aneurysms of the descending and thoracoabdominal aorta

A Novel Microwave Sensor to Detect Specific Biomarkers in Human Cerebrospinal Fluid and Their Relationship to Cellular Ischemia During Thoracoabdominal Aortic Aneurysm Repair

“…In the patients that developed spinal cord ischaemia there was a strong correlation between S100β and lactate levels in the CSF compared to those who did not. Anderson et al analysed the CSF and serum of 11 patients who underwent thoracoabdominal aneurysm surgery and measured S100β, lactate, neuronal specific endolase, glial fibrillary acidic protein [30]. One patient suffered stroke following surgery, which cause significant rises in all biochemical markers measured in the CSF.…”

“…However, although there is a good correlation to spinal cord ischaemia and rises in CSF lactate, there is a lag between its rise and development of CSF lactate [25]. There is now considerable interest with respects to specific biomarkers that can be biochemically analysed and are more sensitive to spinal cord ischaemia than lactate [26][27][28][29][30][31]. In particular, interest has arisen in the area of protein level monitoring, and so the aim of this work is to determine the ability of EM wave sensors to measure varying quantities of protein.…”

Glial and Axonal Body Fluid Biomarkers Are Related to Infarct Volume, Severity, and Outcome

“…11,[25][26][27] One patient described by Anderson et al developed a stroke following surgery for an aneurysm of the thoracoabdominal aorta. 28 To the best of our knowledge, there are no published studies on combined CSF and serum S100B levels in a well defined cohort of patients with an ischaemic cerebrovascular event.…”

Multilevel somatosensory evoked potentials and cerebrospinal proteins: indicators of spinal cord injury in thoracoabdominal aortic aneurysm surgery

“…Such markers will generally reflect release from any CNS tissue. A pilot study demonstrated an increase in several biochemical markers with both cerebral and spinal cord injury [8].…”