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Cited by 238 publications
(92 citation statements)
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“…With respect to the subtypes of the enzyme, it was shown that MPP+ potently and competitively inhibits MAO-A, which therefore does not significantly contribute to the conversion of MPTP to MPP +. The B form of the enzyme which appears to be only slightly inhibited by MPP + (Fritz et al, 1985), plays the predominant role in the bioactivation of MPTP (Singer et al, 1987). However, in the light of the present findings, i.e.…”
Section: Discussioncontrasting
confidence: 54%
See 1 more Smart Citation
“…With respect to the subtypes of the enzyme, it was shown that MPP+ potently and competitively inhibits MAO-A, which therefore does not significantly contribute to the conversion of MPTP to MPP +. The B form of the enzyme which appears to be only slightly inhibited by MPP + (Fritz et al, 1985), plays the predominant role in the bioactivation of MPTP (Singer et al, 1987). However, in the light of the present findings, i.e.…”
Section: Discussioncontrasting
confidence: 54%
“…However, in the light of the present findings, i.e. the increase of both endogenous 5-HT and the 5-HT/5-HIAA ratio by nanomolar concentrations of the neurotoxin (Figure 2), the ability of MPP + to inhibit MAO in 5-hydroxytryptaminergic terminals may be of greater importance than suggested by Singer et al (1987).…”
Section: Discussioncontrasting
confidence: 52%
“…There is evidence in the literature supportive of a role for mitochondrial dysfunction in other neurodegenerative disorders such as Alzheimer's disease (67) and a form of Parkinson's disease (68). Studies of scrapie-infected hamsters have reported physical disruption of the mitochondria as well as decreased activity of important mitochondrial enzymes (69).…”
Section: Discussionmentioning
confidence: 99%
“…However, most of the debate centered around the 'mitochondrial hypothesis', namely that, despite their dissimilar structures, MPP ÷ acts like rotenone to inhibit mitochondrial respiration versus the 'oxidative stress' hypothesis, which assumes that the effects of hydroxyl and superoxide radicals caused nigrostriatal cell death. The ultimate question, which remains open, is whether the similarity in neuronal lesions and neurological symptoms elicited by MPTP and its congeners and those seen in idiopathic parkinsonism suggests that evironmental compounds of related structure may be causative agents in human parkinsonism [13][14]. The present review summarizes recent advances in these areas and other advances of interest to the biochemical community.…”
Section: Introductionmentioning
confidence: 99%