Biochemical Characterization of Human Guanylate Kinase and Mitochondrial Thymidine Kinase: Essential Enzymes for the Metabolic Activation of Nucleoside Analog Prodrugs

Abstract

I would like to express my deepest gratitude to Dr. Manfred Konrad for offering me the opportunity to do my Ph.D. research work in the Enzyme Biochemistry Research Group. It was indeed an honor and great experience to work under his supervision, and in the very dynamic scientific environment of MPI-bpc, Goettingen. I am highly grateful for his guidance and great support in starting several collaborative projects. I am highly thankful to him for reviewing my PhD thesis, and for his very constructive critique and useful comments.My profound gratitude to the Ph.D. thesis committee members, Prof. Dr. Kai Tittmann and