Biochemical Changes in Tissues of Wistar Albino Rats Following Exposure to Diet Incorporated with Locally Processed Fish

Nwaogu, L. A.; Onyeze, G. O. C.

doi:10.9734/arrb/2015/18830

Cited by 3 publications

(6 citation statements)

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“…Administration of MWE, MEE and MDEE to CPO-CCD rats significantly (p<0.05) increase the activity of SOD and CAT in the liver, kidney and brain when compare with the CPO-CCD only and CPO-CCD + Tween 80 respectively. The marked reduction in SOD activity of rats fed CPO-CCD and the enhanced SOD activity when M. myristica extracts was administered were in agreement with other studies (Nwaogu et al, 2011;Sunmonu and Oloyede, 2007). The inhibition of CAT activity during CPO-CCD induced toxicity may be due to the increased generation of reactive free radicals, which can lead to oxidative stress in the cells.…”

Section: Resultssupporting

confidence: 92%

“…However, treatment of rats fed CPO-CCD with the different extracts significantly decreased the level of MDA as compared with that of the control. The excessive ROS generated during crude petroleum oil toxicity rapidly reacted with lipid membranes to initiate the lipid peroxidation chain reaction, resulting in lipid peroxyl radicals' formation (Ita and Edagha, 2016;Ujowundu et al, 2012;Nwaogu et al, 2011). The elevation of lipid peroxidation in rats administered crude petroleum oil has been previously reported (Sunmonu and Oloyede, 2007), which is in this study.…”

Section: Resultssupporting

confidence: 72%

“…Antioxidant enzymes can be inactivated by lipid peroxides (Alantary et al, 2014;Hamza and Al-Harbi, 2015). Subchronic exposure of rats to crude oil, decreases catalase activities in the tissues (Nwaogu et al, 2011). Several studies have shown that, direct exposure to crude oil can disrupt antioxidant status in serum, liver, kidney and brain (Adedara et al, 2012;Ebokaiwe and Farombi, 2016).…”

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confidence: 99%

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Assessment of antioxidant indices after incorporating crude oil contaminated Catfish and African nutmeg (<i>Monodora myrstica</i>) extracts into rat diet

Okpoghono¹,

George²,

Achuba³

2018

Journal of Applied Sciences and Environmental Management

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This study was carried out to assess the antioxidant status of rats fed with diets of catfish contaminated by crude oil and aqueous, ethanol and diethyl ether extracts of Africa nutmeg. Thirty albino rats of weight 180 to 200 g were used for the experiment. They were divided into six groups of five rats each as follows: group 1: control, group 2: rats fed crude petroleum oil contaminated catfish diet (CPO-CCD) only, group 3: CPO-CCD plus tween 80, group 4, 5, and 6 were given CPO-CCD and then treated with M. myristica water extract (MWE), M. myristica ethanol extract (MEE) and M. myristica diethyl ether extract (MDEE). The experiment lasted four weeks. The results showed significant (p < 0.05) decrease in blood reduced glutathione (GSH), blood oxidised glutathione (GSSG), superoxide dismutase (SOD), catalase (CAT) and increase malondialdehyde (MDA) level in the liver, kidney and brain of rats fed CPO-CCD only and CPO-CCD + tween 80 compared to the control. Administration of MWE, MEE and MDEE to the rats fed CPO-CCD significantly (p<0.05) increased the level of blood GSH, blood GSSG, SOD, CAT and decrease MDA level in the liver, kidney and brain when compared with the CPO-CCD only and CPO-CCD + Tween 80. No significant difference was observed in the blood GSH: GSSG ratio in all the experimental groups. In conclusion, M. myristica extracts exhibited beneficial effect on the antioxidant status by evading the oxidative insults elicited by the CPO-CCD intoxication in the various tissues.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 72%

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confidence: 99%

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Assessment of antioxidant indices after incorporating crude oil contaminated Catfish and African nutmeg (<i>Monodora myrstica</i>) extracts into rat diet

Okpoghono¹,

George²,

Achuba³

2018

Journal of Applied Sciences and Environmental Management

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“…The marked reduction in SOD and catalase activities of rats fed COD and the enhanced SOD and catalase activities when red palm oil was administered were in agreement with other studies (Achuba and Otuya, 2006;Sunmonu and Oloyede, 2007;Nwaogu et al, 2011) (Tables 2 and 3). Treatment of COD with red palm oil reversed the activities of antioxidant enzymes: superoxide dismutase and catalase in the organs/tissues of rats.…”

Section: Resultssupporting

confidence: 92%

“…Excessive free radical is generated during crude oil toxicity that initiates membrane lipid disintegration (Achuba and Osakwe, 2003;Nwaogu et al, 2011;Ujowundu et al, 2012;Ita and Edagha, 2016). This explains the increase in membrane lipid peroxidation in the tissues of rats fed COD (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Modulation of crude oil induced alteration of oxidative stress indices in rat by red palm oil

Achuba¹

2018

Journal of Applied Sciences and Environmental Management

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The toxic properties of crude oil were hitherto described. Therefore, several materials are being tested for protective potential counter to petroleum toxicity. This study evaluated the oxidative stress status of rats fed diet incorporating petroleum tainted diet with red palm oil. Four groups with six rats in each group were employed in this study. Rats in group 1 were fed with fish feed only while rats in group 2 were fed with crude oil tainted diet and rats in groups 3 and 4 were fed with contaminated feed that was pre-treated with 4 ml and 8 ml of red palm oil respectively. The rats were exposed to the respective diet for 30 days and had water freely. Thereafter standard analytical methods were used to measure oxidative stress markers in organs/tissues of rats. The results showed that crude oil tainted diet stimulated lipid peroxidation and cause decline in reduced glutathione level, superoxide dismutase and catalase activities in the organ/tissues of rats which were significant (P < 0.05) relative to control. Pre-treatment of the rat diets with red palm oil significantly (P < 0.05) drop lipid peroxidation and increase level of antioxidant markers in the organ/tissues of rats in relation to the values in rats fed with diet tainted with crude oil only. This study has confirmed that red palm oil can evade the oxidative insult elicited by crude oil intoxication in various organs/tissues. Therefore, red palm oil should be made a major dietary component for inhabitants of petroleum producing areas of the world.

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Phytochemical and Vitamin Contents of Mangifera indica (Mango) Fruits Subjected to Ripening by Artificial Methods

Iheagwam¹,

Onyeike²,

Augustine³

2019

IJEAB

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Phytochemical and vitamin contents of ripe, unripe as well as unripe mango (Mangifera indica) fruits subjected to different ripening methods (use of dark polybag, calcium carbide and hot water) were investigated. The Phytochemicals namely carotenoids, phenols, terpenes, alkaloids, tannins, saponins, phytosterols, flavonoids and glycosides were quantified. Natural ripening (control) increased carotenoids (6.53±0.02mg/100g to 11.46±0.04mg/100g), phenols (15.13±0.02 mg/100g to 25.27±0.02 mg/100g), terpenes (0.08±0.02 mg/100g to 1.77±0.02 mg/100g) but decreased alk aloids (0.61±0.00 mg/100g to 0.53±0.02 mg/100g), tannins (2.06±0.02 mg/100g to 1.08±0.02 mg/100g) and flavonoids (56.80±0.01 mg/100g to 35.88±0.02 mg/100g) among others. Among the naturally ripe (control), unripe and artificially ripened mango fruits, there were no significant differences (p<0.05) in vitamins A, B1, B2, and B3. No significant difference (p<0.05) was obtained in the values of B6 for the naturally and artificially ripened mangoes which ranged from 0.20±0.01 mg/100g in calcium carbide group to 0.28±0.06 mg/100g in hot water group, but each was significantly higher than the value for the unripe mango group (0.13±0.02 mg/100g) The levels of vitamin C (mg/100g) was highest in the unripe fruits (51.06±0.05 mg/100g) followed by hot water treated fruits (50.06±0.05 mg/100g) which did not differ significantly (p<0.05) from the values for polybag treated fruits (49.54±0.19 mg/100g) but each was significantly higher than the value for the naturally ripe fruits (30.90±0.14 mg/100g). In general, it may be concluded that artificial ripening methods increased the phytochemical constituents and vitamin levels in the fruits investigated.

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Biochemical Changes in Tissues of Wistar Albino Rats Following Exposure to Diet Incorporated with Locally Processed Fish

Cited by 3 publications

References 0 publications

Assessment of antioxidant indices after incorporating crude oil contaminated Catfish and African nutmeg (<i>Monodora myrstica</i>) extracts into rat diet

Assessment of antioxidant indices after incorporating crude oil contaminated Catfish and African nutmeg (<i>Monodora myrstica</i>) extracts into rat diet

Modulation of crude oil induced alteration of oxidative stress indices in rat by red palm oil

Phytochemical and Vitamin Contents of Mangifera indica (Mango) Fruits Subjected to Ripening by Artificial Methods

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