Biochemical Biomarkers of Mucosal Healing for Inflammatory Bowel Disease in Adults

Krzystek−Korpacka, Małgorzata; Kempiński, Radosław; Bromke, Mariusz A.; Neubauer, Katarzyna

doi:10.3390/diagnostics10060367

Cited by 48 publications

(46 citation statements)

References 145 publications

(123 reference statements)

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“…We decided not to include data on CRP or imaging markers (magnetic resonance imaging, ultrasound) in detecting MH. A previous comprehensive analysis regarding the role of CRP in this setting was recently published by Krzystek-Korpacka et al [ 11 ]. In this review of 30 studies, there was a large variation in the selected optimal cutoff values, ranging from 0.4 mg/L to 28 mg/L.…”

Section: Discussionmentioning

confidence: 99%

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Surrogate markers of mucosal healing in inflammatory bowel disease: A systematic review

State¹,

Negreanu²,

Voiosu³

et al. 2021

WJG

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BACKGROUND Mucosal healing (MH) has emerged as a key therapeutic target in inflammatory bowel disease (IBD), and achievement of this goal is documented by endoscopy with biopsy. However, colonoscopy is burdensome and invasive, and substitution with an accurate noninvasive biomarker is desirable. AIM To summarize published data regarding the performance of noninvasive biomarkers in assessing MH in IBD patients. METHODS We conducted a systematic review of studies that reported the performance of biomarkers in diagnosing MH in patients with IBD. The main outcome measure was to review the diagnostic accuracy of serum and fecal markers that showed promising utility in assessing MH. RESULTS We screened 1301 articles, retrieved 46 manuscripts and included 23 articles for full-text analysis. The majority of the included manuscripts referred to fecal markers (12/23), followed by circulatory markers (8/23); only 3/23 of the included manuscripts investigated combined markers (serum and/or fecal markers). Fecal calprotectin (FC) was the most investigated fecal marker for assessing MH. In ulcerative colitis, for cutoff levels ranging between 58 mcg/g and 490 mcg/g, the sensitivity was 89.7%-100% and the specificity was 62%-93.3%. For Crohn’s disease, the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g (sensitivity 50%-95.9% and specificity 52.3%-100%). The best performance for a serum marker was observed for the endoscopic healing index, which showed a comparable accuracy to the measurement of FC and a higher accuracy than the measurement of serum C-reactive protein. CONCLUSION Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization.

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Section: Discussionmentioning

confidence: 99%

“…Neither imaging markers nor urine-based markers were included in this analysis. Studies investigating the role of C-reactive protein (CRP) in detecting MH were also not included, as a comprehensive analysis regarding this subject was recently published[ 11 ]. In this review, 30 eligible publications regarding CRP were included.…”

Section: Methodsmentioning

confidence: 99%

Surrogate markers of mucosal healing in inflammatory bowel disease: A systematic review

State¹,

Negreanu²,

Voiosu³

et al. 2021

WJG

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“…Regarding fecal biomarkers, there is still controversy about the optimal cut-off points determining remission. However, as shown on the table, the mean values for calprotectin and lactoferrin were above the suggested thresholds of remission [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

et al. 2020

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Branched-chain amino acids (BCAAs) are involved in immune system’s metabolic pathways and play fundamental role in gut health. Our aim was to assess BCAA plasma levels in patients with ulcerative colitis (UC) and associations of plasma BCAAs with disease-related parameters. This was a case-control study in adult patients with UC and BMI-matched controls. A total of 150 volunteers were screened between May 2016 and June 2017; 43 patients and 34 healthy controls were enrolled. Medical and dietary history (3 × 24 h recalls, MedDiet score), anthropometric measurements, blood and fecal samples were collected. We measured BCAAs in plasma with gas chromatography-mass spectrometry. In patients, fecal calprotectin, lactoferrin, lysozyme and defensin were quantified. Dietary pattern was similar in patients and controls. Plasma-free BCAA profiles did not differ between groups. Regression analysis showed that i) valine was inversely associated with calprotectin (p = 0.007) and ii) isoleucine with age (p = 0.031), after adjusting for age, sex, PMS and smoking. Leucine was negatively associated with age (p = 0.015) after adjusting for age, sex and PMS, but this association vanished when smoking was introduced. No correlation was observed between total BCAAs with any of the parameters. Plasma-free valine is negatively associated with calprotectin in patients with UC.

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“…Therapeutic strategy in UC has evolved into a "treat to target" approach. The most commonly accepted therapeutic targets became endoscopic remission (defined as Mayo Endoscopic Score; MES ≤ 1) and clinical remission, that is, patient-reported outcome (defined as resolution of rectal bleeding and diarrhea/altered bowel habit) [115,116]. Both current and novel treatment options are now evaluated based on their efficiency in the mucosal healing (MH) induction [117].…”

Section: Markers Of Mucosal Healingmentioning

confidence: 99%

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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Biochemical Biomarkers of Mucosal Healing for Inflammatory Bowel Disease in Adults

Cited by 48 publications

References 145 publications

Surrogate markers of mucosal healing in inflammatory bowel disease: A systematic review

Surrogate markers of mucosal healing in inflammatory bowel disease: A systematic review

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

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