Biochemical and histological liver changes occurred after iron supplementation and possible remediation by garlic consumption

Abstract

Iron liver excess is associated to biochemical and histological liver perturbations. Our aim was to know even if fresh garlic consumption can remediate these problems. Three groups of rats were utilized: control group A, iron overload group B and garlic and iron overload group C. Important morphological and biochemical modifications were obtained in group B rats comparatively to control group A. Indeed, body and liver weights and liver iron contents increased, respectively, by 12.5 ± 0.06%; 17 ± 0.25% and 35 ± 0.11% comparatively to controls. Radical cation scavenging ability in liver cytosol of group B rats was significantly low (54 ± 0,1%) in comparison to group A. Garlic consumption allowed the group C to achieve an increase by 46 ± 0,11 and 75 ± 0,14% of total antioxidant capacity comparatively to group A and B rats. For the serum ALAT, ASAT, triglyceride and LDH levels, they increased in iron-treated rats, respectively, by 25 ± 0.21; 15 ± 0.12; 30 ± 0.14 and 22 ± 0.16% comparatively to controls. These perturbations were accompanied by deep histological changes. After food fresh garlic supplementation, we had found a deep regulation of all modified parameters showing a hepatoprotective effect of garlic against iron liver excess. Garlic chemical compounds have curative effects on iron liver excess.

Protective effects of lycopene on oxidative stress, proliferation and autophagy in iron supplementation rats

“…An increased serum iron with decreased TIBC in iron group was shown here. When plasma iron concentration exceeds the iron-binding capacity of transferrin, iron accumulates in the body as non-transferrin bound iron and prone to the formation of reactive oxygen species (ROS) and causes cell damages (Papanikolaou and Pantopoulos, 2005;Ghorbel et al, 2011). However, lycopene treatment in the combined group prevented iron-damages by decreasing the level of serum iron and increasing the iron-binding capacity.…”

Polyphenolic constituents and antioxidant/antiradical activity in different extracts of Alstonia scholaris (Linn.)

“…Recently, much attention has been paid on dietary supplementation of phytochemicals having potent radicals scavenging capacity and reducing lipid peroxidation during oxidative damage in mammals (Ghorbel et al, 2011;Shirzad et al, 2011;Yoon et al, 2012). Studies have shown that A. scholaris extract supplementation inhibit radiation induced lipid peroxidation and glutathione level (Gupta et al, 2008) by protecting the hematopoietic system against radiation induced alterations in mice (Gupta et al, 2013).…”