Bioavailability of the dietary antioxidant flavonol quercetin in man

Hollman, P.C.H.; Trijp, J.M.P. van; Mengelers, Marcel; Vries, J.H.M. de; Katan, Martijn B.

doi:10.1016/s0304-3835(97)04644-2

Cited by 188 publications

(97 citation statements)

References 5 publications

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“…Inter-individual variation is evident in both the extent of absorption and rate of clearance of the dose with maximal plasma concentrations in the range of 40 ± 220 ngaml being observed at 7 h in two subjects (Figure 1). The kinetics of quercetin absorption following rutin dosing are similar to those previously reported by Hollman et al (1997b). Clearance is not complete in 24 h and so the possibility exists that signi®cant accumulation might occur in the blood after repeated daily supplementation.…”

Section: Discussionsupporting

confidence: 82%

“…For ease of analysis, plasma quercetin was measured in acid-hydrolysed samples as a marker of rutin absorption (Hollman et al, 1996c). The effects of glycosylation on quercetin absorption have been studied for quercetin, quercetin glucosides and quercetin-3-rutinoside and uptakes of 24%, 52% and 17% respectively reported (Hollman et al, , 1997b. Signi®cantly elevated plasma concentrations of quercetin were found in all three volunteers following dosing with rutin ( Figure 1).…”

Section: Discussionmentioning

confidence: 99%

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Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Boyle¹,

Dobson²,

Duthie³

et al. 2000

Eur J Clin Nutr

179

107

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Objective: To determine the potential antioxidant effect of rutin (quercetin-3-O-b-rutinoside) supplementation. Design: A 6-week randomized single-blind placebo controlled trial was conducted; 500 mg rutin supplement was compared to an equivalent amount of glucose placebo. In addition, a pharmacokinetic study was carried out. Setting: The Rowett Research Institute, Aberdeen, UK. Subjects: Eighteen healthy non-obese normocholesterolaemic female volunteers in the age range 18 ± 48 y. Main outcome measures: Plasma¯avonoids, ascorbic acid, tocopherols and carotenoids, plasma antioxidant capacity, lymphocyte DNA damage, blood chemistry and haematology, liver function tests, urinary malondialdehyde, 8-hydroxy-2H -deoxyguanosine and 8-iso-prostaglandin F 2a . Results: Eighteen volunteers completed the trial. Rutin supplementation did not induce any adverse changes in blood chemistry or indices of liver function. Plasma¯avonoids were signi®cantly elevated in the rutinsupplemented group. Endogenous oxidation of pyrimidines was signi®cantly decreased in both rutin-and placebo-treated volunteers. There was no signi®cant change in the level of urinary 8-hydroxy-2 H -deoxyguanosine or urinary malondialdehyde in either group. A linear correlation was observed between urinary malondialdehyde and urinary 8-iso-prostaglandin F 2a (R 0.54, P`0.01). Conclusion: Six weeks' rutin supplementation signi®cantly elevated the levels of three plasma¯avonoids (quercetin, kaempferol and isorhamnetin) but there was no signi®cant change in plasma antioxidant status. The decrease in the level of endogenous base oxidation in lymphocyte DNA seen in both the placebo-and rutinsupplemented subjects may re¯ect seasonal changes in other dietary antioxidants.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Boyle¹,

Dobson²,

Duthie³

et al. 2000

Eur J Clin Nutr

179

107

View full text Add to dashboard Cite

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“…The difference in absorption rate was attributed to glycosylation in quercetin metabolism. Previous studies have revealed that onions contain an abundant amount of flavonol glycosides as quercetin derivatives (9,17). Flavonoids have been used as a diuretic agent and anti-inflammatory in folk medicine and certain flavonoid-rich types of onion exhibit anticancer properties (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

Pan

Zheng

2018

Oncol Lett

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“…In Asian countries, for example, the ingestion of isoflavonoids reaches, in some cases, 28 mg daily (Fukutabe et al, 1996;Nakamura et al, 2000). The plasma concentration after ingestion of these substances is relatively high (Franke et al, 1998;Watanabe et al, 1998) and can persist for 2 days, suggesting that by repeated inclusion of certain foods in the diet, these substances could accumulate in plasma (Hollman et al, 1997;De Vries et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

ReviewLeukemia/lymphoma-associated gene fusions in normal individuals

Ms¹

2008

Genet. Mol. Res.

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ABSTRACT. Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence of these rearrangements indicates that such translocations can be generated in normal hematopoietic cells without apparent oncogenic consequences. This article reviews and discusses the data available in the literature.

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Bioavailability of the dietary antioxidant flavonol quercetin in man

Cited by 188 publications

References 5 publications

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

ReviewLeukemia/lymphoma-associated gene fusions in normal individuals

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