Bioavailability of microencapsulated ferrous sulfate in powdered milk produced from fortified fluid milk: a prophylactic study in rats

Lysionek, Alexis; Zubillaga, Marcela; Salgueiro, M.; Piñeiro, Adriana; Ricardo, A.; Weill, R; Boccio, José

doi:10.1016/s0899-9007(01)00742-0

Cited by 24 publications

(6 citation statements)

References 10 publications

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“…Liposome technology as a special kind of microencapsulation technique has been extensively investigated and used in many fields as a delivery system (Huang, 2008;Keller, 2001;Lasic, 1998;Mozafari et al, 2008). The common iron salt, ferrous sulfate, has been microencapsulated with liposomes (Lysionek et al, 2002;Olivares, 2002;Xia and Xu, 2005). Because iron have been encapsulated in the interior volume of liposomes, to keep the iron from contacting the other components of food by the phospholipids bilayer membrane, the interaction between iron in liposomes and the other components of food is restricted.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and the stability of ferrous glycinate nanoliposomes

Ding

Zhang

Hayat

et al. 2011

Journal of Food Engineering

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization and the stability of ferrous glycinate nanoliposomes

Ding

Zhang

Hayat

et al. 2011

Journal of Food Engineering

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“…The effect of this phagocytosis is the passive incorporation of the entrapped drug into a desirable organ such as the liver, spleen, or kidney . The common iron salt ferrous sulfate has been microencapsulated with liposomes , , . Because iron compounds were encapsulated in the interior phase of liposomes, the iron was kept from contacting the other components of food by the phospholipid bilayer membrane, so the interaction between iron compounds in liposomes and the other components of food was restricted.…”

Section: Introductionmentioning

confidence: 99%

Preparation and pH Stability of Ferrous Glycinate Liposomes

Ding

Xia

Hayat

et al. 2009

J. Agric. Food Chem.

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Ferrous glycinate liposomes were prepared by reverse phase evaporation method. The effects of cholesterol, Tween 80, ferrous glycinate concentration, hydrating medium, pH of hydrating medium, and sonication strength on the encapsulation efficiency of liposomes were investigated. Encapsulation efficiency was significantly influenced by the different technique parameters. Ferrous glycinate liposomes might be obtained with high encapsulation efficiency of 84.80% under the conditions of optimized technique parameters. The zeta potential and average particle size of liposomes in the hydrating medium of pH 7.0 were 9.6 mV and 559.2 nm, respectively. The release property of ferrous glycinate liposomes in vitro was investigated in simulated gastrointestinal juice. A small amount of ferrous glycinate was released from liposomes in the first 4 h in simulated gastrointestinal juice. The mean diameters of liposomes increased from 559.2 to 692.9, 677.8, and 599.3 nm after incubation in simulated gastrointestinal juice of pH 1.3, 7.5, and 7.5 in the presence of bile salts, respectively. Results showed that the stability of ferrous glycinate in strong acid environment was greatly improved by encapsulation in liposomes, which protected ferrous glycinate from disrupting the extracapsular environment by lipid bilayer. The bioavailability of ferrous glycinate, as the iron source for biological activity including hemoglobin formation, may be increased. The ferrous glycinate liposomes may be a kind of promising iron fortifier.

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“…Um composto com todas essas características era desconhecido até pouco tempo, porém com o advento do processo de microencapsulação de FeSO 4 , essa possibilidade tornou-se promissora. Na Argentina, um composto de ferro microencapsulado com lecitina de soja, SFE141 ® , demonstrou elevada biodisponibilidade, tanto em testes in vitro como in vivo [14][15][16][17] . O propósito deste estudo foi avaliar a biodisponibilidade de um novo composto de ferro revestido de uma camada de polissacarídeo natural, genericamente denominado Ferlim, desenvolvido no Brasil pelo Instituto de Pesquisas Tecnológicas do Governo do Estado de São Paulo (IPT) 18,19 , para ser utilizado na fortificação de farinha de trigo 20 .…”

Section: N T R O D U ç ã Ounclassified

Avaliação por métodos in vitro e in vivo da biodisponibilidade de sulfato ferroso microencapsulado

et al. 2007

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OBJETIVO: Avaliar, por métodos in vitro e in vivo, a biodisponibilidade de uma nova forma de sulfato ferroso microencapsulado (genericamente denominado Ferlim), desenvolvido para a fortificação de alimentos, comparando-a com a de ferro eletrolítico (Fe0). MÉTODOS: A avaliação da dialisabilidade in vitro utilizou como matriz leite em pó reconstituído. A avaliação in vivo, utilizando o método de recuperação de hemoglobina em leitões anêmicos, teve duração de 13 dias e os animais (n=23) foram agrupados de acordo com o produto do peso (kg) x hemoglobina (g/dL). Como controle foi utilizado FeSO4.7H2O. RESULTADOS: As porcentagens médias de ferro dialisado foram 2,2 (desvio-padrão=0,1)%, 3,4 (desvio-padrão=0,1)% e 3,6 (desvio-padrão=0,0)% para FeSO4.7H2O, Ferlim e Fe0, respectivamente (p<0,05). A absorção de ferro foi de 16,0 (desvio-padrão=3,1)% para o grupo controle, de 15,1 (desvio-padrão=3,8)% para o grupo Ferlim e de 12,8 (desvio-padrão=4,3)% para o grupo Fe0, não sendo significantemente diferentes (p>0,05). As porcentagens de absorção do valor biológico relativo do FeSO4.7H2O foram de 94,2 (desvio-padrão=23,8)% para o grupo Ferlim e de 79,7 (desvio-padrão=26,6)% para o grupo Fe0, sem diferenças significantes (p>0,05). Em valores numéricos (p>0,05), o grupo Fe0 apresentou menor média de absorção (%) valor biológico relativo de concentração de ferro total, de ferro heme e não-heme no fígado. CONCLUSÃO: A microencapsulação do sulfato ferroso com alginato mantém sua biodisponibilidade, caracterizando-se como boa alternativa para a fortificação de misturas sólidas.

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Bioavailability of microencapsulated ferrous sulfate in powdered milk produced from fortified fluid milk: a prophylactic study in rats

Cited by 24 publications

References 10 publications

Preparation, characterization and the stability of ferrous glycinate nanoliposomes

Preparation, characterization and the stability of ferrous glycinate nanoliposomes

Preparation and pH Stability of Ferrous Glycinate Liposomes

Avaliação por métodos in vitro e in vivo da biodisponibilidade de sulfato ferroso microencapsulado

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