Bioavailability of different methionine sources for growing broilers

Sangali, Cleiton Pagliari; Bruno, Luís; Nunes, Ricardo José; Neto, Adhemar Rodrigues de Oliveira; Pozza, Paulo Cesar; Oliveira, Taciana Cavalcante de; Frank, Rafael; Schone, Rodrigo André

doi:10.1590/s1516-35982014000300006

Cited by 9 publications

(28 citation statements)

References 23 publications

(28 reference statements)

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“…Although some more recent papers (Zou et al., ; Agostini et al., ; Kluge et al., ; Vazquez‐Añon et al., ) appeared to demonstrate bioequivalence between HMTBa and dl ‐methionine in poultry, the FEEDAP Panel concludes on the weight of evidence that HMTBa is likely to be less efficacious than dl ‐methionine in all non‐ruminant species. The main reasons for this lower bioefficacy are (i) the fact that the gut microbiota of the small intestine compete with the host more for HMTBa than for dl ‐methionine (Drew et al., ; Malik et al., ), (ii) commercial HMTBa and its salts may contain besides the free acid/salt, significant amounts of dimers, trimers and oligomers, known to have a lower bioefficacy depending on the manufacturing process (Boebel and Baker, ; Saunderson, ; Van Weerden et al., ; Liu et al., ; Hoehler et al., ; Zimmerman et al., ; Dilger and Baker, ; Elwert et al., ; Shoveller et al., ; Opapeju et al., ; Zelenka et al., ; Sangali et al., ) (see Appendix A).…”

Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Additives¹,

Rychen²,

Aquilina³

et al. 2018

EFS2

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The European Commission asked EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) to deliver a scientific opinion on the safety and efficacy of ADRY+®. ADRY+® consists of hydroxy analogue of methionine (HMTBa) and its calcium salt (HMTBa‐Ca), both precursors of l‐methionine. HMTBa and HMTBa‐Ca are currently authorised for use as a nutritional additives, under the functional group ‘amino acids, their salts and analogues’. ADRY+® is produced by chemical synthesis and it is intended to be used in feed for all animal species and categories. The FEEDAP Panel concluded that ADRY+® is safe for the target animals. The use of the additive in animal nutrition is not expected to result in an accumulation of HMTBa or its metabolites in edible tissues and animal products. Therefore, its use does not raise safety concerns for the consumer. ADRY+® is irritant to eyes and not irritant to the skin. The FEEDAP Panel cannot conclude on the skin sensitisation potential of this additive. The exposure of the users to the additive by inhalation is expected to be low. The use of this product as a feed additive does not represent a risk to the environment. ADRY+® is an effective source of methionine for protein synthesis in non‐ruminant animals and fish, although HMTBa may show a lower bioefficacy than dl‐methionine. In ruminants, HMTBa is more slowly degraded in the rumen than dl‐methionine.

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Section: Assessmentmentioning

confidence: 99%

Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Additives¹,

Rychen²,

Aquilina³

et al. 2018

EFS2

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show abstract

“…Тварині не потрібно витрачати додаткові життєві ресурси та енергії для переведення частини D-метіоніну в L-метіонін. Виходячи з отриманих в ході досліджень даних (Jiao et al, 2010;Kratzer, Littell, 2006;Kubińska et al, 2014;Liu et al, 2010;Mitchell, Lemme, 2008;Narayanswamy, Bhagwat, 2010;Paulicks et al, 2009;Sangali et al, 2014;Vazquez-Anon et al, 2006;Yi et al, 2007), очевидно, що джерела метіоніну мають різну ефективність. Тому метою наших досліджень було визначити вплив різних джерел метіоніну у комбікормах на продуктивність та забійні якості перепелів м'ясного напряму продуктивності.…”

Section: вступunclassified

Продуктивність Та Забійні Якості Перепелів При Використанні Різних Джерел Метоніну В Раціонах

Sychov

Chsherbina

2017

Ukr J Ecol

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The authors have investigated the effect of different sources of metonin in the diets of quails on their productivity and carcass quality. Experimental studies were carried out with Pharaoh quails in Problematic Research Laboratory of Feed Additives in the National University of Life and Environmental Sciences of Ukraine. The experiment was carried out by method of groupsanalogues. Compound feed were fed in dry crumbled form; young birds were fed in a group. The daily amount of compound feed was divided in two parts -morning and evening rations with different sources of metonin (DL-metonin, L-metonin and МНА)). We have found that compound feed with the L-metonin contributes to live body weight increase by 5.3% or 13 g, average daily growth by 5.9 % or 0.37 g, reduces feed conversion by 2.1%, increases the mass of not gutted carcass, semi gutted carcass and gutted carcass of 12.5 (6.2%), 12.5 (6.2%), and 10.5 g (6.4%); increases the mass of pectoral muscles and muscles of the pelvic limbs by 7.37 and 6.49 g (18.2% and 24.5%) and mass of liver by 0.94 g. Use of diets with MНA and DL-methionine did not significantly effect the productivity and carcass quality, whereas entry to the diet of MNA increased feed conversion by 5.4%. During the study period the safety of livestock which was fed with different sources of metonin ranged from 93 to 96%. We believed the further research are needed to examine the impact of different sources of metonin on the egg production of egg-laying quails, morphological and chemical composition of eggs and their hatching quality. Key words: quail, DL -metonin, L -metonin, MHA, live weight, average daily gain, safety, feed conversion, carcass yield.Продуктивність та забійні якості перепелів при використанні різних джерел метоніну в раціонах М.Ю. Сичов, А.М. ЩербинаНаціональний університет біоресурсів і природокористування України, Київ, Україна, E-mail: sychov@ukr.netПроведено оцінку впливу різних джерел метіоніну в раціонах перепелів на продуктивність та забійні якості. Експериментальні дослідження проводились в умовах проблемної науково-дослідної лабораторії кормових добавок Національного університету біоресурсів і природокористування України. Матеріалом для науково-господарського досліду були перепели породи фараон м'ясного напряму продуктивності. Дослід проводився за методом груп-аналогів. Комбікорми згодовували у сухому розсипному вигляді. Годівля молодняку була груповою. Добову кількість комбікорму роздавали дворазово -вранці та ввечері. Вивчено вплив використання різних джерел метіоніну (DL-метіонін, L-метіонін та МНА) в комбікормах на продуктивність та забійні якості молодняку перепелів. Встановлено, що згодовування комбікормів з L-метіоніном сприяє збільшенню живої маси 5,3% або 13 г, середньодобових приростів на 5,9 % або 0,37 г., поліпшує показник конверсії корму на 2,1%, збільшує масу непатраної, напівпатраної і патраної тушки на 12,5 (6,2%), 12,5 (6,2%) та 10,5 г (6,4%), збільшує маси грудних м'язів та м'язів задніх кінцівок на 7,37 і 6, 49 г (18,2% і 24,5%), а печінки на 0,94...

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“…Liquid DL-HMBA has 88% purity while powdered DLM has 98% purity. These two sources have biochemical and physical differences [6]. Methionine serves as a methyl group donor which is involved in non-proteingenic functions.…”

Section: Introductionmentioning

confidence: 99%

Comparative effect of methionine and cysteine supplementation on growth performance and blood profile of Desi chicks

Malik

Iftikhar²

2019

PAB

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Methionine and cysteine are sulfur containing amino acids and have important role in protein synthesis and increases feed efficiency. This study was conducted to evaluate the comparative effect of methionine and cysteine on 22 day old Rhode Island Red (RIR) chicks. The effect of methionine and cysteine was assessed on blood profile and Feed Conversion Ratio (FCR) of Rhode Island Red chicks. Chicks were divided into 7 groups, A,B,C groups were given methionine, having concentrations 0.4 gram per kg (g/kg) body weight (BW), 0.6g/kg BW and 0.7g/kg BW respectively, while groups D,E,F were given the cysteine, having concentrations 0.4g/kg BW, 0.6g/kg BW and 0.7g/kg BW respectively and G was control group that was given the normal basal diet. FCR of the chicks was decreased significantly which indicates better growth performance at all concentrations of methionine and cysteine. Hematological parameters including Hemoglobin (Hb), Hematocrit (PCV), Red Blood Cells (RBCs), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC) and Mean Corpuscular Volume (MCV) were increased in all treatment groups. It is concluded that sulfur containing amino acid are growth enhancer. These amino acid supplements should be added in animal's diet to improve growth and blood parameters. The study asserts further research on amino acid supplement to examine its effectiveness in other animals.

show abstract

Bioavailability of different methionine sources for growing broilers

Cited by 9 publications

References 23 publications

Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Продуктивність Та Забійні Якості Перепелів При Використанні Різних Джерел Метоніну В Раціонах

Comparative effect of methionine and cysteine supplementation on growth performance and blood profile of Desi chicks

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