Bioavailability of cadmium from crab hepatopancreas and mushroom in relation to inorganic cadmium: A 9-week feeding study in mice

Comparative effect of water and food-chain mediated cadmium exposure in rats

“…b Feed intake was measured only for rats exposed to Cd in diet (controls were pairfed) c Cd intake of rats exposed to Cd in water and diet was calculated on the basis of the concentration of Cd in drinking water (0.3 mg Cd/l) and diet (0.4 mg Cd/kg), respectively 2002). This accounts for the use of Cd load in the liver and kidneys in the estimation of Cd uptake in the present study which is also in harmony with previous reports (Andersen et al 1992;Crowe and Morgan, 1997;Reeves and Vanderpool 1998;Lind et al 1995;Lind et al 1998). Thus the significantly (P \ 0.05) smaller combined Cd load of the liver plus that of the kidney of rats exposed to Cd via the experimental food-chain relative to those exposed to the element in drinking water for the same exposure periods (Fig.…”

“…As the liver is the first organ to receive Cd taken up from the gastro-intestinal system via the portal system, the significantly higher liver Cd load of rats fed Cd in diet for 3 months is a likely indication that Cd is more easily available via the food than via the drinking water. Contrary to the present findings Lind et al (1995) who also used Cd accumulation in the liver and kidney as a measure of Cd absorption, demonstrated that bioavailability of Cd from boiled crab hepatopancreas is slightly lower than that of Cd from mushroom and inorganic Cd. This interpretation is based on the results they obtained when female Balb/C mice were fed a diet containing 0.4 ppm Cd from either boiled crab (Cancer pagurus) hepatopancreas or dried mushroom (Agaricus augustus) or as inorganic Cd (CdCl 2 ).…”

Comparative effect of water and food-chain mediated cadmium exposure in rats

“…b Feed intake was measured only for rats exposed to Cd in diet (controls were pairfed) c Cd intake of rats exposed to Cd in water and diet was calculated on the basis of the concentration of Cd in drinking water (0.3 mg Cd/l) and diet (0.4 mg Cd/kg), respectively 2002). This accounts for the use of Cd load in the liver and kidneys in the estimation of Cd uptake in the present study which is also in harmony with previous reports (Andersen et al 1992;Crowe and Morgan, 1997;Reeves and Vanderpool 1998;Lind et al 1995;Lind et al 1998). Thus the significantly (P \ 0.05) smaller combined Cd load of the liver plus that of the kidney of rats exposed to Cd via the experimental food-chain relative to those exposed to the element in drinking water for the same exposure periods (Fig.…”

“…As the liver is the first organ to receive Cd taken up from the gastro-intestinal system via the portal system, the significantly higher liver Cd load of rats fed Cd in diet for 3 months is a likely indication that Cd is more easily available via the food than via the drinking water. Contrary to the present findings Lind et al (1995) who also used Cd accumulation in the liver and kidney as a measure of Cd absorption, demonstrated that bioavailability of Cd from boiled crab hepatopancreas is slightly lower than that of Cd from mushroom and inorganic Cd. This interpretation is based on the results they obtained when female Balb/C mice were fed a diet containing 0.4 ppm Cd from either boiled crab (Cancer pagurus) hepatopancreas or dried mushroom (Agaricus augustus) or as inorganic Cd (CdCl 2 ).…”

Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects.

“…As in the present study, a lack of correlation between BCd or UCd, on the one hand, and Cd intake, on the other, has been reported previously at low exposure levels (Berglund et al 1994). One reason for the present lack of association may be the low and varying bioavailability of Cd from food items (Chan et al 2001;Lind et al 1995Lind et al , 1998 and/or the uncertainty in estimation of Cd intake. In Japan, with a higher dietary exposure and with rice contributing about 40% of the dietary Cd intake, a correlation has been seen Watanabe et al 2000).…”

A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet

“…However, bioavailability of Cd from ingested feed does not always occur with ease. For instance, the bioavailability of Cd from crab hepatopancreas is slightly lower than that from mushroom (Lind et al 1995). With particular reference to the control diet and control rat liver, the evidence here indicates that they were not free of Cd.…”

Comparative effect of water and food-chain mediated cadmium exposure in rats

“…b Feed intake was measured only for rats exposed to Cd in diet (controls were pairfed) c Cd intake of rats exposed to Cd in water and diet was calculated on the basis of the concentration of Cd in drinking water (0.3 mg Cd/l) and diet (0.4 mg Cd/kg), respectively 2002). This accounts for the use of Cd load in the liver and kidneys in the estimation of Cd uptake in the present study which is also in harmony with previous reports (Andersen et al 1992;Crowe and Morgan, 1997;Reeves and Vanderpool 1998;Lind et al 1995;Lind et al 1998). Thus the significantly (P \ 0.05) smaller combined Cd load of the liver plus that of the kidney of rats exposed to Cd via the experimental food-chain relative to those exposed to the element in drinking water for the same exposure periods (Fig.…”

“…As the liver is the first organ to receive Cd taken up from the gastro-intestinal system via the portal system, the significantly higher liver Cd load of rats fed Cd in diet for 3 months is a likely indication that Cd is more easily available via the food than via the drinking water. Contrary to the present findings Lind et al (1995) who also used Cd accumulation in the liver and kidney as a measure of Cd absorption, demonstrated that bioavailability of Cd from boiled crab hepatopancreas is slightly lower than that of Cd from mushroom and inorganic Cd. This interpretation is based on the results they obtained when female Balb/C mice were fed a diet containing 0.4 ppm Cd from either boiled crab (Cancer pagurus) hepatopancreas or dried mushroom (Agaricus augustus) or as inorganic Cd (CdCl 2 ).…”

Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects.

“…As in the present study, a lack of correlation between BCd or UCd, on the one hand, and Cd intake, on the other, has been reported previously at low exposure levels (Berglund et al 1994). One reason for the present lack of association may be the low and varying bioavailability of Cd from food items (Chan et al 2001;Lind et al 1995Lind et al , 1998 and/or the uncertainty in estimation of Cd intake. In Japan, with a higher dietary exposure and with rice contributing about 40% of the dietary Cd intake, a correlation has been seen Watanabe et al 2000).…”

A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet

“…However, bioavailability of Cd from ingested feed does not always occur with ease. For instance, the bioavailability of Cd from crab hepatopancreas is slightly lower than that from mushroom (Lind et al 1995). With particular reference to the control diet and control rat liver, the evidence here indicates that they were not free of Cd.…”

Comparative effect of water and food-chain mediated cadmium exposure in rats

“…b Feed intake was measured only for rats exposed to Cd in diet (controls were pairfed) c Cd intake of rats exposed to Cd in water and diet was calculated on the basis of the concentration of Cd in drinking water (0.3 mg Cd/l) and diet (0.4 mg Cd/kg), respectively 2002). This accounts for the use of Cd load in the liver and kidneys in the estimation of Cd uptake in the present study which is also in harmony with previous reports (Andersen et al 1992;Crowe and Morgan, 1997;Reeves and Vanderpool 1998;Lind et al 1995;Lind et al 1998). Thus the significantly (P \ 0.05) smaller combined Cd load of the liver plus that of the kidney of rats exposed to Cd via the experimental food-chain relative to those exposed to the element in drinking water for the same exposure periods (Fig.…”

“…As the liver is the first organ to receive Cd taken up from the gastro-intestinal system via the portal system, the significantly higher liver Cd load of rats fed Cd in diet for 3 months is a likely indication that Cd is more easily available via the food than via the drinking water. Contrary to the present findings Lind et al (1995) who also used Cd accumulation in the liver and kidney as a measure of Cd absorption, demonstrated that bioavailability of Cd from boiled crab hepatopancreas is slightly lower than that of Cd from mushroom and inorganic Cd. This interpretation is based on the results they obtained when female Balb/C mice were fed a diet containing 0.4 ppm Cd from either boiled crab (Cancer pagurus) hepatopancreas or dried mushroom (Agaricus augustus) or as inorganic Cd (CdCl 2 ).…”

Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects.

“…As in the present study, a lack of correlation between BCd or UCd, on the one hand, and Cd intake, on the other, has been reported previously at low exposure levels (Berglund et al 1994). One reason for the present lack of association may be the low and varying bioavailability of Cd from food items (Chan et al 2001;Lind et al 1995Lind et al , 1998 and/or the uncertainty in estimation of Cd intake. In Japan, with a higher dietary exposure and with rice contributing about 40% of the dietary Cd intake, a correlation has been seen Watanabe et al 2000).…”

A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet

“…However, bioavailability of Cd from ingested feed does not always occur with ease. For instance, the bioavailability of Cd from crab hepatopancreas is slightly lower than that from mushroom (Lind et al 1995). With particular reference to the control diet and control rat liver, the evidence here indicates that they were not free of Cd.…”