Bioavailability and catabolism of green tea flavan-3-ols in humans

Rio, Daniele Del; Calani, Luca; Cordero, Chiara; Salvatore, Sara; Pellegrini, Nicoletta; Brighenti, Furio

doi:10.1016/j.nut.2009.09.021

Cited by 164 publications

(135 citation statements)

References 22 publications

Supporting

Mentioning

131

Contrasting

Order By: Relevance

“…Bioavailability of dietary plant metabolites based on detection in plasma (Donovan, Manach, Faulks, & Kroon, 2006) is likely underestimations of true bioavailability if metabolites of colonic flora are also considered (Del Rio et al, 2010). Thus, assuming plant polyphenolics are bioavailable to gut, the question remains as to whether in vitro mechanisms of inhibition are likely to be operative in vivo.…”

Section: Significance Of In Vitro Results For In Vivo Efficacymentioning

confidence: 99%

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Patten

Abeywardena

Head

et al. 2012

Journal of Functional Foods

View full text Add to dashboard Cite

Section: Significance Of In Vitro Results For In Vivo Efficacymentioning

confidence: 99%

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Patten

Abeywardena

Head

et al. 2012

Journal of Functional Foods

View full text Add to dashboard Cite

“…In a cohort of elderly Japanese individuals, the composition of the gut microbiota was highly correlated with the rate of quercetin metabolism. The abundance of Surreellaceae and Oscillospiraceae were negatively correlated with quercetin metabolism, while Fusobacteria and Enterobacteriaceae showed a positive correlation [64], Furthermore, using 20 healthy volunteers who were administered green tea, one study found that colonic microbiota produced polyhydroxyphenyl-γ-valerolactones, which was the urinary catabolite produced in the greatest concentrations; it was shown to have a 10 times greater concentration than the other flavan-3-ol conjugates [65]. Recently phenyl-γ-valerolactones have been purported to provide protection to brown adipocytes against oxidative damage, which may provide an important observation for research into obesity [66].…”

Section: The Gut Microbiota and Its Role In The Generation Of Bioactimentioning

confidence: 99%

The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice

Pasinetti

Singh

Westfall

et al. 2018

JAD

View full text Add to dashboard Cite

A growing body of experimental data suggests that microbes in the gut influence behavior and can alter brain physiology and neurochemistry. Although promising, researchers are only starting to understand the potential of the gut microbiota for use in neurological disease. Recent evidence demonstrated that gastrointestinal activities are linked to mood disorders such as anxiety, depression, and most recently, cognitive functions in age-related neurodegenerative disorders. Studies from our group and others are uncovering new evidence suggesting that the gut microbiota plays a crucial role in the metabolism and bioavailability of certain dietary compounds and synthetic drugs. Based on this evidence, this review article will discuss the implications of the gut microbiota in mechanisms of bioavailability and biotransformation with an emphasis on dietary polyphenol compounds. This will be followed by a survey of ongoing innovative research identifying the ability of individual gut bacteria to enhance the bioavailability of gut-derived, brain-penetrating, bioactive polyphenol metabolites that ultimately influence mechanisms associated with the promotion of resilience against psychological and cognitive impairment in response to stress. Lastly, current research initiatives aimed at promoting the generation of brain bioactive polyphenol metabolites by specialized gut microbes will be discussed, specifically the use of gnotobiotic mice to develop bioengineered second generation probiotics. We propose that leveraging the gut microbial ecosystem to generate brain targeted bioactive metabolites from dietary polyphenols can attenuate lifestyle risk factors and promote resilience against age-related cognitive decline.

show abstract

“…To understand these findings, it is important to consider the results from bioavailability studies, which unanimously report large interindividual differences [28,30,41,42,43]. Genetic predisposition [44] and nutrition patterns interacting with polyphenol absorption [40,45] are among the factors that were postulated to contribute to the interindividual variations.…”

Section: Introductionmentioning

confidence: 99%

“…Genetic predisposition [44] and nutrition patterns interacting with polyphenol absorption [40,45] are among the factors that were postulated to contribute to the interindividual variations. The microbiome hypothesis seeks to explain the varying effects of green tea administration through the impact of the gut microbiome [28,42]. Not only do colonic ring fission valerolactones account for almost 90% of excreted catechin metabolites, they also show wide variability that is likely to result from differences in the colonic microflora [42].…”

Section: Introductionmentioning

confidence: 99%

“…The microbiome hypothesis seeks to explain the varying effects of green tea administration through the impact of the gut microbiome [28,42]. Not only do colonic ring fission valerolactones account for almost 90% of excreted catechin metabolites, they also show wide variability that is likely to result from differences in the colonic microflora [42]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Megow¹,

Darvin²,

Meinke³

et al. 2017

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Background: Oxidative stress plays an important role in the pathogenesis of various skin diseases. Thus, the antioxidant network of the skin relies on the uptake of exogenous antioxidants to ensure cell protection against radical formation. Green tea is one of the main sources of polyphenolic antioxidant compounds, but only few data are available on its cutaneous antioxidant effects. Methods: The radical scavenging properties of Benifuuki and Yabukita green tea were investigated in the human skin. Thirty-two participants who met the inclusion criteria were randomized to consume 3 cups per day of either Benifuuki tea, Yabukita tea, or water (control group) for 2 weeks. Electron paramagnetic resonance (EPR) spectroscopy was applied to measure the radical scavenging capacity of the skin in vivo before and after the intervention. Results: Both Yabukita and Benifuuki tea led to an increase in the radical scavenging activity of the skin by 28 and 29%, respectively, and the difference was significant when compared to the control group. Benifuuki tea, previously reported to be superior in bioavailability due to a highly absorbable methylated catechin, did not prove to be more effective than the common Yabukita tea. Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.

show abstract

Bioavailability and catabolism of green tea flavan-3-ols in humans

Cited by 164 publications

References 22 publications

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

Processed dietary plants demonstrate broad capacity for angiotensin converting enzyme and angiotensin II receptor binding inhibition in vitro

The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice

A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin

Contact Info

Product

Resources

About