Bioadhesives for clinical applications – a mini review

Uma, K.

doi:10.1039/d2ma00941b

Cited by 9 publications

(2 citation statements)

References 68 publications

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“…Bioadhesives represent one of the most attractive solutions for esophageal wound shielding. Now, there are many commercial bioadhesives for clinical use [7,25,26]. However, the harsh environment of the esophagus raises higher requirements for bioadhesives [7].…”

Section: Discussionmentioning

confidence: 99%

“…A tissue adhesive forms bonds with its substrate to provide sufficient adhesion. The adhesion strength of tissue adhesives depends on the balance between interaction within the tissue adhesive (cohesion) and the tissue adhesive-substrate interface (adhesion) [25,26]. Because there is a limited number of proteins on the tissue surface, pure ODA showed very low adhesion strength in the porcine skin model (figure 2(B)).…”

Section: Discussionmentioning

confidence: 99%

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A pilot study on endoscopic delivery of injectable bioadhesive for esophageal repair in a porcine model

Xia,

Wang,

Guo

et al. 2024

Biomed. Mater.

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Endoscopic submucosal dissection (ESD) is the gold-standard surgical procedure for superficial esophageal cancer. A significant and challenging complication of this technique is post-ESD esophageal stricture. In this study, the feasibility of endoscopic catheter delivery of bioadhesive to esophageal lesions in a porcine model was tested. Injectable bioadhesive was composed of oxidized dextran (ODA) and chitosan hydrochloride (CS), its physicochemical properties, injectability, antibacterial activity, and cytocompatibility were investigated before in vivo test. ODA-CS bioadhesive was delivered to the wound bed of the esophageal tissue using a custom-made catheter device after ESD in a porcine model. Our results show that the ODA-CS bioadhesive is of good injectability, tissue adhesive strength, antibacterial capacity, and blood compatibility. In vivo delivery was achieved by endoscopic spraying of ODA and CS in separate catheters fixed on the endoscopic probe. ODA and CS can be mixed well to allow in situ bioadhesive formation and firmly adhere to the esophageal wound surface. After two weeks, the bioadhesive maintained structural integrity and adhered to the surface of esophageal wounds. However, histological analysis reveals that the ODA-CS bioadhesive did not show improvement in attenuating inflammatory response after ESD. This pilot study demonstrates the feasibility of ODA-CS bioadhesive for shielding esophageal wounds after ESD, whereas efforts need to improve its anti-inflammatory activity to reduce fibrosis for stricture prevention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A pilot study on endoscopic delivery of injectable bioadhesive for esophageal repair in a porcine model

Xia,

Wang,

Guo

et al. 2024

Biomed. Mater.

View full text Add to dashboard Cite

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Multifunctional coatings hinging on the catechol/amine interplay

Alfieri,

Panzella,

Napolitano

2023

Eur J Org Chem

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Design and implementation of functional coatings is a topic of active research in a variety of health‐related applications, most of which require wet adhesion. The powerful wet adhesion of mussel byssus proteins rich in DOPA and lysine residues provided a clue to realize that the combination of a catechol and an amine component has a specific role in the interfacial adhesion. From this natural model, polydopamine (PDA)‐based coatings have been developed that result from the oxidative polymerization of dopamine combining the catechol and amine functionalities in the same molecule. Covalent interactions resulting from Michael‐type addition or Schiff‐base formation of the polymeric products from dopamine oxidation as well as non‐covalent π‐stacking and cation‐π interactions exemplify the diverse mode of catechol/amine interplay that have been identified as responsible of the adhesion and cohesion properties of PDA. In the last decade coatings inspired to the same chemistry but using different starting materials have been explored particularly catechols of natural origin and different amine components, while mechanistic studies with model compounds have allowed to rationalize the structural requirements for adhesion and to expand the potential of these functional coatings.

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Phenylboronic acid-functionalized biomaterials for improved cancer immunotherapy via sialic acid targeting

Jangid,

Kim

2024

Advances in Colloid and Interface Science

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Bioadhesives for clinical applications – a mini review

Abstract: Bioadhesives are highly biocompatible and biodegradable polymers, which are used to join two surfaces where at least one of them is a living tissue.

Cited by 9 publications

References 68 publications

A pilot study on endoscopic delivery of injectable bioadhesive for esophageal repair in a porcine model

A pilot study on endoscopic delivery of injectable bioadhesive for esophageal repair in a porcine model

Multifunctional coatings hinging on the catechol/amine interplay

Phenylboronic acid-functionalized biomaterials for improved cancer immunotherapy via sialic acid targeting

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