Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2012.03.013 View full text
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Ju-Ching Yeh, Ian J. Garrard, Chin-Wen Chantal Cho, S.W. Annie Bligh, Guang-hua Lu, Tai-Ping Fan, Derek Fisher

Abstract: In natural product research, it is a common experience that fractionation of biologically-active crude extracts can lead to the loss of their original activity. This is attributed to synergistic effects, where two or more components are required to be present together for full activity of the sample. Our previous study showed that a volatile oil of Angelica sinensis radix (VOAS) inhibited endothelial cell proliferation in culture. Here we have used a bioactivity-guided fractionation method to preserve any syne…

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