2021
DOI: 10.3390/polym13020279 View full text |Buy / Rent full text
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Abstract: Cells grown on bioactive matrices have immensely advanced many aspects of biomedical research related to drug delivery and tissue engineering. Our main objective was to perform simple evaluation of the structural and biotic qualities of cell scaffolds made of affordable biomaterials for liver cell line (HepG2) cultivation in vitro. In this work the electrospun matrix made of synthetic polyester poly(ε-caprolactone) (PCL) was compared with the natural protein-based extracellular matrix isolated from porcine liv… Show more

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“…Slivac et al also manufactured electrospun PCL mats, and tested the effects of PCL mats and liver extracellular matrix scaffolds on the bioactivity of HepG2 cells. 55 Kim et al promoted the regenerative treatment of the liver injury by stacking patient-specific progenitor cell sheets onto multiscale electrospun fibers. 56 The results showed that the liver patch was a technique for the generation of an artificial liver, which might have potential clinical application value in the future.…”
Section: Polycaprolactone (Pcl)mentioning
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“…Slivac et al also manufactured electrospun PCL mats, and tested the effects of PCL mats and liver extracellular matrix scaffolds on the bioactivity of HepG2 cells. 55 Kim et al promoted the regenerative treatment of the liver injury by stacking patient-specific progenitor cell sheets onto multiscale electrospun fibers. 56 The results showed that the liver patch was a technique for the generation of an artificial liver, which might have potential clinical application value in the future.…”
Section: Polycaprolactone (Pcl)mentioning
“…Drug delivery is always anticipated to be "safe, effective, and convenient" for patients [1][2][3][4][5]. To achieve this goal, drug release profiles must be modified regardless of the drug administration routes [6][7][8][9][10][11]. During the past half a century, both pharmaceutical technologies and excipients broadly expanded to create novel functional materials for realizing a wide variety of modified release profiles of active ingredients, which show potential applications in drug delivery, food engineering, cosmetics, and so on [12][13][14][15][16][17][18][19].…”
Section: Introductionmentioning
“…25 In recent studies, electrospinning has provided significant contributions to liver tissue engineering. [26][27][28][29][30][31][32][33][34][35][36][37] In particular one study combined electrospinning and laparoscope techniques to deliver nanofibres directly into the liver of a living pig, and the results showed advantages such as less inflammatory responses and faster recovery than other traditional methods. 34 Also it is an excellent way to combine other proteins such as liver ECM, collagen, fibronectin and chitosan to create a tailored scaffold to influence hepatocyte phenotype.…”
Section: Introductionmentioning
“…19 Interestingly, one highlight from recent studies also confirmed electrospun PCL mats can exhibit some similar responses to original liver tissue. 35 It has been shown that the morphology of fibres can significantly effect cell behaviour and growth. 2,17 With fibre alignment publicised to affect cell elongation and orientation.…”
Section: Introductionmentioning
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