Bioactivity and health effects of garlic essential oil: A review

Abstract

Garlic (Allium sativum L.), the underground bulb of the Allium plant in the family Liliaceae, is a common and popular spice that has historically been used to prevent and treat many different diseases such as pain, deafness, diarrhea, tumors, and other healthy problems. Garlic essential oil contains a variety of organosulfur compounds, such as the most representative diallyl disulfides (DADS) and diallyl trisulfides (DATS), which have attracted great interest in medicine, food, and agriculture because of their rich biological activities. This paper reviews the research progress on the composition and bioactivities of garlic essential oil mixtures and the bioactivity of some typical monomeric sulfides in garlic essential oil. The active mechanisms of representative sulfides in garlic essential oil were analyzed, and the applications of garlic essential oil in functional food, food additives, and clinical treatment were discussed. Combined with the current research status, the limitations and development direction of garlic essential oil in the study of molecular mechanism were discussed, which is of great significance to the development of garlic essential oil as a natural and safe alternative medicine for treatment.

Role of oral phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens

“…The addition of garlic essential oils in chicken ration acted by immunomodulation via bioavailability of nutrients required to synthesize antibodies and promote development of the immune system of chickens ( Elbaz et al, 2022 ). Claims by ( Huang et al, 2023 ) demonstrated that garlic essential oil supports the immune system by improving the phagocytic activity of heterophages and explaining the rate of peroxidation induced by ROS production.…”

Essential Oils for the Treatment and Management of Nonalcoholic Fatty Liver Disease (NAFLD)

“…[56][57][58] Garlic essential oil (GO) emerges as a novel therapeutic tool with potential benefits in preventing cancer, alleviating oxidative damage and inflammation, preserving liver health, and reducing blood sugar levels. 59 Previous research underscores the promising effects of organosulfur compounds derived from GO, such as diallyl disulfide and diallyl trisulfide, in addressing the multifaceted challenges presented by NAFLD. 60 Lai et al reported that GO and its active compound DAD exhibited anti-NAFLD effects in obese mice by regulating key enzymes and molecules involved in lipid synthesis and metabolism, including SREBP-1c, acetyl-CoA carboxylase, FAS, and PPAR-α.…”

Green and sustainable natural derived polysulfides for a broad range of applications

“…Inverse vulcanization of diallyl disulfide (DAS), an essential oil of garlic, 145 and myrcene, a natural terpene from thyme, 146 as natural dienes with sulfur at 185 °C produced polysulfides that were suitable candidates for cathodes in Li–S batteries (Fig. 10a).…”