Bioactivity and cytocompatibility of dicalcium phosphate/poly (amino acid) biocomposite with degradability

Zhang, Yunfei; Shan, Wenpeng; Li, Xiangde; Wei, Jie; Li, Hong; Ma, Jian; Yan, Yonggang

doi:10.1016/j.apsusc.2011.10.109

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…This might be relative to the scale of inorganic particles in the composite. According to our results, BG/PAA composites exhibit different interface (as shown in Figure 3) with those of the HA/PAA, CDHA/PAA, and DCP/PAA composites because of the bigger particle size of BG than HA, CDHA, and DCP 30,31,36 . The pH value of the physiological environment is often affected by degradation products of a biomaterial implanted in vivo, and hence it would influence cellular and tissue responses 24,37 .…”

Section: Discussionmentioning

confidence: 74%

Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials

Zheng

Dai

Wei

et al. 2020

J of Applied Polymer Sci

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Bioglass (BG) possesses excellent bioactivity and has been widely used in the manufacture of biomaterials. In this study, a composite with different surface bioactivity was fabricated via in situ melting polymerization by incorporating BG and poly(amino acid) (PAA) at a suitable ratio. The structure of the composite was characterized by Fourier transform infrared spectroscopy and XRD. The compressive strength of the BG/PAA composites was 139 MPa (BG: PAA = 30:70). The BG/PAA composites were degradable, and higher BG in composite showed higher weight loss after 4 weeks of incubation in simulated body fluid. In addition, the BG/PAA composite maintained adequate residual compressive strength during the degradation period. The SEM results showed the differences in surface bioactivities of the composites directly, and 30BG/ PAA composite showed thicker apatite layer and higher Ca/p than 15BG/PAA. in vitro MG-63 cell culture experiments showed that the composite was noncytotoxic and thus allows cells to adhere, proliferate, and differentiate. This indicates that the composite has good biocompatibility. The implantations in the bone defects of rabbits for 4 and 12 weeks were studied. The composites had good biocompatibility and were capable of guiding new bone formation without causing any inflammation. The composite may be successfully used in the development of bone implants.

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Section: Discussionmentioning

confidence: 74%

Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials

Zheng

Dai

Wei

et al. 2020

J of Applied Polymer Sci

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“…A modified PAA copolymer was synthesized with ε‐aminohexanoic acid as the main framework and other natural amino acids as the block group, and this copolymer had molecular groups similar to those of collagen protein in natural bone . Also, PAA was biocompatible and bioactive when combined with inorganics of Ca–P ceramic, as we found in a previous study . Calcium sulfate (CS) is recognized as a well‐tolerated material in bone regeneration .…”

Section: Introductionmentioning

confidence: 84%

“…Thus, the combination of the bioactivities of CS and HA and the reasonable mechanical properties of polymers is of interest for the development applicable composites with improved properties for bone regeneration. Furthermore, our previous work about PAA illustrated that some certain PAAs possessed excellent mechanical properties and biocompatibility, and the addition of inorganic ceramics improved its bioactivity and other properties …”

Section: Introductionmentioning

confidence: 99%

Effects of the surface modification of poly(amino acid)/hydroxyapatite/calcium sulfate biocomposites on the adhesion and proliferation of osteoblast‐like cells

Fan

Ren

Liu³

et al. 2015

J of Applied Polymer Sci

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In this study, we focused on the surface modification of a novel poly(amino acid) (PAA)/hydroxyapatite/calcium sulfate composite and the effect of its surface modification on cellular responses. The surface modification was performed by sandblasting (sample S2), calcium chloride ethanol saturated solution etching (sample S3), and formic acid etching (sample S4) followed by in vitro culturing of osteoblast‐like cells. The obtained results indicate that a new interface of the composite was formed during the modification, and the modified surface was changed with respect to its surface morphology by physical abrasion. The calcium chloride ethanol saturated solution etchant etched PAA selectively whereas forming rich calcium‐phosphate (Ca–P) apatite on the surface of S3. The formic acid etchant attacked the inorganic component without changing the PAA state. Cell attachment and cell proliferation were improved by the treatments of S2 and S3 in comparison with no treatment and the treatment of S4 © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42427.

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“…15,16 Among these composites, poly(amino acid) (PAA) composites were the newly developed biocomposites which were composed of PAA and inorganic bioceramics. 17 Inorganic bioceramics used in this kind of composites could be chosen from HA, CS, Tricalcium Phosphate, etc. [18][19][20] In previous work, a series of PAA copolymers and their composites have been prepared, proved to be tailored physical, controllable biodegradable, biocompatible, and nontoxic by changing different kinds of amino acid.…”

Section: Introductionmentioning

confidence: 99%

Mechanics, degradability, bioactivity, in vitro, and in vivo biocompatibility evaluation of poly(amino acid)/hydroxyapatite/calcium sulfate composite for potential load-bearing bone repair

et al. 2015

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A ternary composite of poly(amino acid), hydroxyapatite, and calcium sulfate (PAA/HA/CS) was prepared using in situ melting polycondensation method and evaluated in terms of mechanical strengths, in vitro degradability, bioactivity, as well as in vitro and in vivo biocompatibility. The results showed that the ternary composite exhibited a compressive strength of 147 MPa, a bending strength of 121 MPa, a tensile strength of 122 MPa, and a tensile modulus of 4.6 GPa. After immersion in simulated body fluid, the compressive strength of the composite decreased from 147 to 98 MPa for six weeks and the bending strength decreased from 121 to 75 MPa for eight weeks, and both of them kept stable in the following soaking period. The composite could be slowly degraded with 7.27 wt% loss of initial weight after soaking in phosphate buffered solution for three weeks when started to keep stable weight in the following days. The composite was soaked in simulated body fluid solution and the hydroxyapatite layer, as flower-like granules, formed on the surface of the composite samples, showing good bioactivity. Moreover, it was found that the composite could promote proliferation of MG-63 cells, and the cells with normal phenotype extended and spread well on the composite surface. The implantation of the composite into the ulna of sheep confirmed that the composite was biocompatible and osteoconductive in vivo, and offered the PAA/HA/CS composite promising material for load-bearing bone substitutes for clinical application.

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Bioactivity and cytocompatibility of dicalcium phosphate/poly (amino acid) biocomposite with degradability

Cited by 9 publications

References 35 publications

Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials

Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials

Effects of the surface modification of poly(amino acid)/hydroxyapatite/calcium sulfate biocomposites on the adhesion and proliferation of osteoblast‐like cells

Mechanics, degradability, bioactivity, in vitro, and in vivo biocompatibility evaluation of poly(amino acid)/hydroxyapatite/calcium sulfate composite for potential load-bearing bone repair

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