Bioactivities from Marine Algae of the Genus Gracilaria

Almeida, Cynthia Layse Ferreira de; Falcão, Heloina de Sousa; Lima, Gedson Rodrigues de Morais; Montenegro, Camila de Albuquerque; Lira, Narlize Silva; Athayde-Filho, Petrônio Filgueiras de; Rodrigues, Luís Cézar; Souza, María de Fátima Vanderlei de; Barbosa-Filho, José Maria; Batista, Leônia Maria

doi:10.3390/ijms12074550

Cited by 191 publications

(106 citation statements)

References 96 publications

(106 reference statements)

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“…The report that Gracilaria spp. has been used in the treatment of stomach disorders (Trono, 1999) and the usefulness of carrageenan in ulcer therapy (De Almeida et al, 2011), substantiated the antiulcer activity of G. crassa in the present study. Also, the sulfated algal polysaccharides (Silva et al, 2011) in the seaweeds may provide an effective protection against gastric damage.…”

Section: Discussionsupporting

confidence: 80%

Antiulcer, wound healing and hepatoprotective activities of the seaweeds Gracilaria crassa, Turbinaria ornata and Laurencia papillosa from the southeast coast of India

Senthil¹,

Murugan²

2013

Braz. J. Pharm. Sci.

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Seaweeds have bioactive compounds of interest in the pharmaceutical industry. In India, seaweeds are used exclusively for phycocolloids production and have not yet received consideration as a dietary supplement. So, it has become imperative to explore the biomedical potential of seaweeds and promote their utilization as a functional food. The seaweeds Turbinaria ornata, Gracillaria crassa and Laurencia papillosa, collected from the Tuticorin coast of the Southeast coast of India and selected based on preliminary screening, were extracted with acetone and evaluated for antiulcer, wound healing and hepatoprotective activities. L. papillosa showed the highest level of gastric protection activity (81%) at 200 mg/kg, comparable to the standard drug ranitidine (90%). G. crassa followed with 76%. G. crassa and L. papillosa, showed marked wound-healing activity. G. crassa at 200 mg/kg, showed a marked effect on the serum marker enzymes indicating prominent hepatoprotective activity. The noteworthy wound-healing and hepato-protective properties of G. crassa besides anti-ulcer activity next to L. papillosa were indicative of its potential for further consideration.Uniterms: Seaweed/biomedical potential. Seaweed/antiulcer activity. Seaweed/wound-healing. Seaweed/ hepatoprotective activity. Gracilaria crassa/biomedical potential. Turbinaria ornata/biomedical potential. Laurencia papillosa/biomedical potential.Algas marinhas possuem compostos bioativos de interesse para a indústria farmacêutica. Na Índia, as algas marinhas são usadas exclusivamente para a produção de ficocolóides e ainda não receberam a consideração como um suplemento dietético. Assim, tornou-se imperativo explorar o potencial biomédico de algas e promover a sua utilização como alimento funcional. As algas marinhas Turbinaria ornata, Gracillaria crassa e Laurencia papillosa, coletadas de Tuticorin, na costa sudeste da Índia, e selecionadas com base em triagem preliminar, foram extraídas com acetona e avaliadas quanto à atividade antiúlcera, de cicatrização de feridas e de hepatoproteção. L. papillosa mostrou o mais alto nível da atividade de proteção gástrica (81%) na dose de 200 mg/kg, comparável ao fármaco padrão, ranitidina (90%). G. crassa mostrou atividade de 76%. G. crassa e L. papillosa mostrou atividade martcante na cicatrização de feridas. G. Crassa, a 200 mg/kg, mostrou efeito alto sobre o marcador sérico das enzimas, indicando atividade hepatoprotetora proeminente. A notável cura de feridas e as propriedades hepatoprotetoras de G. Crassa, além da atividade antiúlcera, próxima da L. Papillosa, foram indicativos do seu potencial para uma análise mais aprofundada.

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Section: Discussionsupporting

confidence: 80%

Antiulcer, wound healing and hepatoprotective activities of the seaweeds Gracilaria crassa, Turbinaria ornata and Laurencia papillosa from the southeast coast of India

Senthil¹,

Murugan²

2013

Braz. J. Pharm. Sci.

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“…Furthermore, considering the use of biomass in the market of high-value bioactive products (KUMAR et al, 2008;YOKOYAMA and ISHIHI, 2010;ALMEIDA et al, 2011), the cultivation of seaweeds in IMTA becomes even more economically interesting.…”

Section: *Calculated Data Based On Cited Study; Nd -No Datamentioning

confidence: 99%

Biofiltering efficiency and productive performance of macroalgae with potential for integrated multi-trophic Aquaculture (IMTA)

Castelar¹,

Pontes²,

Costa³

et al. 2015

Bol. Inst. Pesca

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Seaweeds have many uses in industry and agriculture and many species have potential for integrated multi-trophic aquaculture (IMTA), since they are efficient in removing nutrients from water. The efficiency of Ulva flexuosa, U. fasciata and Gracilaria birdiae in removing nutrients from enriched water and their productive performance in outdoor tanks were quantified. These seaweeds (50 g; n = 5) were grown in tanks containing 50 L of eutrophic seawater, with a salinity of 30, a temperature of 28.5 ± 2.8 °C, an irradiance of 547 ± 458 μmol photons m -2 s -1 and aeration. The nutrients levels were recorded daily and when total nitrogen removal was detected, the biomass was measured. After five days of cultivation, more than 98% of NH3 (H = 1.1; P = 0.56) and NO3 -(H = 2.7; P = 0.25) and 62.1% of PO4 3-(H = 0.0; P = 0.90) had been removed from the tanks. However, the mean daily growth rate (4.5 ± 2.5% day -1 ) and productivity (3.5 ± 1.9 g m -2 day -1 ) of U. fasciata and G. birdiae were higher than U. flexuosa (-13.6 ± 7.7% day -1 ; -6.24 ± 2.8 g m -2 day -1 ; P<0.01), demonstrating that microalga contamination by this species promoted high removal efficiency in the tanks, but a low productive performance. Based on these results, U. fasciata and G. birdiae show a greater potential for use in IMTA to improve water quality and produce biomass.Keywords: Gracilaria birdiae; productivity; daily growth rate; nutrient removal; Ulva fasciata; Ulva flexuosa EFICIÊNCIA BIOFILTRADORA E DESEMPENHO PRODUTIVO DE MACROALGAS COMPOTENCIAL PARA AQUICULTURA MULTI-TRÓFICA INTEGRADA (AMTI) RESUMOAs macroalgas são utilizadas em diversos setores industriais e agrícolas. Além disso, muitas espécies apresentam potencial para aquicultura multitrófica integrada (AMTI), pois são eficientes na remoção de nutrientes da água. A eficiência biofiltradora e desempenho produtivo das macroalgas Ulva flexuosa, U. fasciata e Gracilaria birdiae e foram quantificados em tanques outdoor. As algas (50 g; n = 5) foram cultivadas em tanques de 50 L, com água eutrofizada, salinidade 30 e temperatura média 28,3 °C. Os nutrientes foram monitorados diariamente e a biomassa foi mensurada assim que detectada a extinção do nitrogênio. Após cinco dias de cultivo, mais de 98% de NH3 (H = 1,1; P = 0,56) e de NO3 -(H = 2,7; P = 0,25) e 62,1% de PO4 3-(H = 0,0; P = 0,9) foram removidos dos tanques. Contudo, a taxa de crescimento (% dia -1 ) e a produtividade (g m -2 dia -1 ) de U. fasciata e de G. birdiae (4,5 ± 2,5% dia -1 ; 3,5 ± 1,9 g m -2 dia -1 ) foram superiores às de U. flexuosa (13,6 ± 7,7% dia -1 ; 6,2 ± 2,8; P<0,01), cuja contaminação por microalgas contribuiu para elevada eficiência de retirada nos tanques desta espécie, mas baixo desempenho produtivo. Desta forma, U. fasciata e G. birdiae foram indicadas para AMTI tanto para a manutenção da qualidade da água quanto para aproveitamento de biomassa.

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“…Numerous bioactive primary and secondary metabolites identified within the genus Gracilaria and Hypnea have been reported in literature. [7][8][9] In the light of these results and of worldwide great interest in marine biomass as a source of bioactive compounds (for the nutraceutical, pharmaceutical and cosmetic industry), the aim of this work was to screen rapidly the chemical compositions of two of the most abundant algae growing in Corsican lagoons (Its' ecosystem was formerly studied by Pasqualini et al 10 ) and to take into account the algae biomass as a potential multi product source for the cosmetic industry.…”

Section: Introductionmentioning

confidence: 99%

Rapid Screening of Chemical Compositions of Gracilaria dura and Hypnea mucisformis (Rhodophyta) from Corsican Lagoon.

Xu¹,

Sutour²,

Casabianca³

et al. 2015

Intl J Phyto Natu Ingrd

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Bioactivities from Marine Algae of the Genus Gracilaria

Cited by 191 publications

References 96 publications

Antiulcer, wound healing and hepatoprotective activities of the seaweeds Gracilaria crassa, Turbinaria ornata and Laurencia papillosa from the southeast coast of India

Antiulcer, wound healing and hepatoprotective activities of the seaweeds Gracilaria crassa, Turbinaria ornata and Laurencia papillosa from the southeast coast of India

Biofiltering efficiency and productive performance of macroalgae with potential for integrated multi-trophic Aquaculture (IMTA)

Rapid Screening of Chemical Compositions of Gracilaria dura and Hypnea mucisformis (Rhodophyta) from Corsican Lagoon.

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