Bioactivities, biosynthesis and biotechnological production of phenolic acids in Salvia miltiorrhiza

Abstract

Salvia miltiorrhiza (Danshen in Chinese), is a well-known traditional Chinese medicinal plant, which is used as not only human medicine but also health-promotion food. Danshen has been extensively used for the treatment of various cardiovascular and cerebrovascular diseases. As a major group of bioactive constituents from S. miltiorrhiza, water-soluble phenolic acids such as salvianolic acid B possessed good bioactivities including antioxidant, anti-inflammatory, anti-cancer and other health-promoting activities. It is of significance to improve the production of phenolic acids by modern biotechnology approaches to meet the increasing market demand. Significant progresses have been made in understanding the biosynthetic pathway and regulation mechanism of phenolic acids in S.miltiorrhiza, which will facilitate the process of targeted metabolic engineering or synthetic biology. Furthermore, multiple biotechnology methods such as in vitro culture, elicitation, hairy roots, endophytic fungi and bioreactors have been also used to obtain pharmaceutically active phenolic acids from S. miltiorrhiza. In this review, recent advances in bioactivities, biosynthetic pathway and biotechnological production of phenolic acid ingredients were summarized and future prospective was also discussed.

The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients

“…Tanshinone is a natural terpenoid and the main bioactive component isolated from traditional Chinese medicine Salvia miltiorrhiza. It is traditionally used in the treatment of cardiovascular and cerebrovascular diseases in China Shi et al, 2019;Sun et al, 2019). Modern pharmaceutical studies showed that tanshinone also possess antiangiogenic, antioxidant, antibacterial, anti-inflammatory, and antitumor activities (Wang et al, 2016;Gao et al, 2017;Zhou et al, 2017).…”

SmMYB2 promotes salvianolic acid biosynthesis in the medicinal herb Salvia miltiorrhiza

“…Exogenous MeJA treatment significantly promotes salvianolic acid accumulation in S. miltiorrhiza hairy roots In recent years, salvianolic acid compounds have found widespread use as treatments for coronary heart disease and angina pectoris. Among these compounds, RA and SAB have high economic value and medicinal efficacy (Shi et al 2019). Therefore, studying the molecular mechanism of salvianolic acid biosynthesis could facilitate efforts to promote the accumulation of salvianolic acids in plants.…”

Silver nanoparticle pollutants activate oxidative stress responses and rosmarinic acid accumulation in sage

“…Based on several studies, PAL is known as a critical enzyme in the production of many phenolic compounds such as flavonoids, lignans, coumarins and phenolic acids (Xu et al 2016, Nourozi et al 2019. Some reports have also confirmed that PAL is a committed-step enzyme responsible for RA biosynthesis (Nourozi et al 2019, Shi et al 2019. Results disclosed that SNPs-induced PAL activity that catalyzes the conversion of phenylalanine to the precursors of phenolic compounds.…”