Bioactive secondary metabolites from Plectranthus glandulosus Hook. (Lamiaceae)

An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals from Plectranthus glandulosus towards MDR Phenotypes

“…Moreover, many techniques for isolation, characterization, and pharmacological evaluation have led to an interest in plant secondary metabolites as a source of new drugs, which are potential antimicrobials [42][43][44]. Previous chemical studies of that plant resulted in the isolation of many compounds among which those belonging to the phytochemical classes such as flavonoids are known for their antimicrobial activities [20,42]. In this study, many other known phytochemical compounds have been isolated from P. glandulosus (Figure 1), and their antibacterial activities were evaluated.…”

“…Known as Ava in “Ewondo,” a local tongue in Cameroon, the plant is used as a spice in this part of the country [ 17 ]. Some compounds including one methoxylated flavonoid derivative, plectranmicin, and one monoterpene derivative, plectranmicinol, together with seven known compounds including 5-hydroxy-3,7,2′,4′tetramethoxyflavone; 5,7-dihydroxy-3,2′,4′-trimethoxyflavone; 7-hydroxy-5,6,4′-trimethoxyflavone; 3-epi-betulinic acid; 3- O - β -D-glucopyranosyl; stigmasterol; β -sitosterol, and 4-epi-fridelin were isolated from the whole plant of the studies species [ 20 ]. Earlier biological studies reported the antinociceptive and anti-inflammatory effects [ 21 ] as well as the antioxidant and insecticidal activities of P. glandulosus [ 22 , 23 ].…”

In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions

“… ∗ The different flavonoids have the same m/z. The assignments were done in comparison with the literature [ 32 , 33 ]. …”

“…Phytochemical examination of P. glandulosus revealed the presence of secondary metabolites such as alkaloids, flavonoids, saponins, terpenoids, steroids, tannins, and glucosides [ 28 – 31 ]. Further phytochemical studies isolated a methoxylated flavonoid derivative plectranmicin, a monoterpene derivative plectranmicinol, and seven known compounds (5-hydroxy-3,7,2′,4′-tetramethoxyflavone, 5,7-dihydroxy-3,2′,4′-trimethoxyflavone, 7-hydroxy-5,6,4′-trimethoxyflavonen, 3-epi-betulinic acid, 3 -O-β -D-glucopyranosyl stigmasterol, β -sitosterol, and 4-epi-fridelin) [ 32 ]. Nanmeni et al [ 33 ] isolated seventeen compounds form de ethanolic whole plant extract including the mixture of stigmasterol and β -sitosterol, oleanolic acid, pilloin, β -sitosterol 3- O - β -D-glucopyranoside, chrysoeriol, luteolin 7-methyl ether, 5-hydroxy-7,4′-dimethoxyflavone, mixture of maslinic acid and benthamic acid, 5,6-dihydroxy-7,3′,4′-trimethoxyflavone, ladanein, hederagenin, cylicodiscic acid, mixture of chrysoeriol 5- O - β -D-glucopyranoside and 7- O -methyl luteolin 5- O - β -D-glucopyranoside, and galuteolin.…”

In vitro antioxidant properties and inhibitory effect of extracts and fractions of Plectranthus glandulosus leaves on copper sulfate (CuSO4)-induced oxidation in human low-density lipoprotein

“…Earlier studies reported the antinociceptive and anti-inflammatory effects 13 as well as antioxidant and insecticidals activities 14,15,16 . As phytochemical constituents of P. glandulosus, one new methoxylated flavonoid derivative, plectranmicin and one new monoterpene derivative, plectranmicinol, together with seven known compounds including 5-hydroxy-3,7,2′,4′tetramethoxyflavone; 5,7-dihydroxy-3,2′,4′trimethoxyflavone; 7-hydroxy-5,6,4′trimethoxyflavonen; 3epi-betulinicacidn; 3O-β-D-glucopyranosylstigmasterol; βsitosterol and 4-epi-fridelin were isolated from the whole plant 17 .…”