Bioactive peptides: signaling the future

Abstract

SummaryNatural processes within the body are modulated almost exclusively by the interaction of specific amino acid sequences, either as peptides or as subsections of proteins. With respect to skin, proteins and peptides are involved in the modulation of cell proliferation, cell migration, inflammation, angiogenesis, melanogenesis, and protein synthesis and regulation. The creation of therapeutic or bioactive peptide analogs of specific interactive sequences has opened the door to a diverse new field of pharmaceutical and active cosmetic ingredients for the skincare industry. Here, we describe the origin of such sequences, their role in nature, their application to dermatology, as well as the advantages and challenges posed by this new technology.

Peptides: Production, bioactivity, functionality, and applications

“…On the other hand, natural bioactive peptides have gained more attention in cosmetics industry rather than drug making, which is justifiable since cosmetics are consumed topically and therefore, toxicity of natural peptides in systemic applications is a minor concern when it comes to the production of natural-peptide-based cosmetics. Bioactive peptides have been specifically emphasized in skincare and cosmetic dermatology because of their ability to stimulate collagen and render botox-like antiwrinkle effect (Fields et al, 2009).…”

Topical Peptide Treatments with Effective Anti-Aging Results

“…Hexapeptide-14 (palmitoyl hexapeptide-14) has been reported to stimulate cell migration, collagen synthesis, and fibroblast proliferation and scaffolding [1]. A 12-week study with 29 volunteers showed results of reduced fine lines and wrinkles by palmitoyl hexapeptide-14.…”

“…The name peptide is coming from pepton [peptos: digested (Greek)]. Naturally occurring human peptides are known for cellular communication, such as protein regulation, cell proliferation, cell migration, inflammation, angiogenesis, and melanogenesis [1], which results in a broad variety of physiological processes including defense, immunity, stress, growth, homeostasis, and reproduction [2]. The first peptides were described by Emil Fischer and Hofmeister in the early 19th century.…”

Characteristics and Applications of Bioactive Peptides in Skin Care

“…적 효과로 인해 고기능성 물질로 인식되고 있다 [5]. 피부 미용 소재로써 BAP의 기능 중 cellular messenger에 관한 연구는 가장 최근이며 [6] 2009년 미국의 경우 스킨케어 성분으로 시장에서 확인된 피부 미용 소재 BAP는 25여 종으로 파악되 었고 [4] 주요 기능은 진피층 콜라겐 합성에 관련된 것이었 다 [5].…”

“…피부 미용 소재로써 BAP의 기능 중 cellular messenger에 관한 연구는 가장 최근이며 [6] 2009년 미국의 경우 스킨케어 성분으로 시장에서 확인된 피부 미용 소재 BAP는 25여 종으로 파악되 었고 [4] 주요 기능은 진피층 콜라겐 합성에 관련된 것이었 다 [5]. Caffeoyl tripeptide-1 (CT-1), digalloyl tetrapeptide-19 (DT-19), nicotinoyl tripeptide-1 (NT-1)은 Fmoc 기반의 고체 상 펩타이드 합성법 (solid phase peptide synthesis; SPPS) 을 이용하여 최근에 개발된 새로운 BAP이다.…”