Bioactive constituents from roots of Bursera tonkinensis

Jutiviboonsuk, Aranya; Zhang, Hongjie; Tan, Ghee Teng; Ma, Ching‐Yung; Hùng, Nguyễn Văn; Cường, Nguyễn Mạnh; Bunyapraphatsara, Nuntavan; Soejarto, Djaja D.; Fong, Harry H. S.

doi:10.1016/j.phytochem.2005.09.025

Cited by 111 publications

(66 citation statements)

References 31 publications

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“…The HMBC experiment displayed a correlation from HÀC(2') to C(4), which evidenced the linkage of the glycerol and sinapyl alcohol units through an O-atom. The signals at d(C) 84.0 (d) and 60.5 (t) represented the three C-atoms when the aromatic ring was degraded in some lignans, such as the known monolignan, bursephenylpropane [25]. Thus, 7 was established as a degraded derivative of 8 : 4'-oxyneolignan, 2-{4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenoxy}propane-1,3-diol, whose parent compound was considered as (7'E)-3,5,3',5'-tetramethoxy-8 : 4'-oxyneolign-7'-ene-4,7,9,9'-tetraol (14) or (7'E)-3,3',5'-trimethoxy-8 : 4'-oxyneolign-7'-ene-4,7,9,9'-tetraol (12).…”

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confidence: 99%

Phenolic Compounds from Selaginella moellendorfii

Wang

2011

Chemistry & Biodiversity

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Chemical investigation of the leaves and roots of Selaginella moellendorfii Hieron has resulted in the isolation and characterization of two new flavone glucosides, 7-O-(β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→6)]-β-glucopyranosyl)flavone-3',4',5,7-tetraol (1) and 7-O-(β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→6)]-β-glucopyranosyl)flavone-4',5,7-triol (2), two new biflavonoids, 2,3-dihydroflavone-5,7,4'-triol-(3'→8″)-flavone-5″,6″,7″,4'''-tetraol (3) and 6-methylflavone-5,7,4'-triol-(3'→O→4''')-6″-methylflavone-5″,7″-diol (4), two new lignans, (7'E)-3,5,3',5'-tetramethoxy-8 : 4'-oxyneolign-7'-ene-4,9,9'-triol (5) and 3,3'-dimethoxylign-8'-ene-4,4',9-triol (6), together with two known monolignans, four known lignans, and four known biflavonoids. Their structures were established by spectroscopic means and by comparison with literature values.

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confidence: 99%

Phenolic Compounds from Selaginella moellendorfii

Wang

2011

Chemistry & Biodiversity

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“…The structures of the isolated compounds were identified by comparing their spec-ν max KBr ν max KBr tral data ( 1 H-and 13 C-NMR) to those reported in the literatures. These compounds were identified as icariside E 4 (1) (Miyase et al, 1989), cupressoside A (2) (Xu et al, 2006), schizandriside (3) (Takani et al, 1979), (+)-isolariciresinol (4) (Achenbach et al, 1992;Jutiviboonsuk et al, 2005), (+)-catechin (5) , quercetin 3-O-β-D-glucopyranoside (6) (Oleszek et al, 2002), 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-β-D-glucopyranoside (7) and (-)-shikimic acid (8) (Ishimaru et al, 1987). Also compounds 2 and 4 were first isolated from the needles of PD.…”

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confidence: 99%

Inhibitory effects of phenolic compounds from needles of Pinus densiflora on nitric oxide and PGE2 production

et al. 2010

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The needles of Pinus densiflora Siebold et Zuccarini, a representative Pinus species that grows in Korea, have been used in oriental traditional medicine as remedies for rheumatitis, hemorrhage, cancer, etc. Phytochemical examination of the needles of Pinus densiflora Siebold et Zuccarini led to the isolation of four lignans, one flavan-3-ol, two flavonols and one organic acid. They were identified as icariside E(4) (1), cupressoside A (2), schizandriside (3), (+)-isolariciresinol (4), (+)-catechin (5), quercetin 3-O-β-D-glucopyranoside (6), 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-β-D-glucopyranoside (7) and (-)-shikimic acid (8). In order to evaluate the anti-inflammatory effects of these compounds, their inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells were examined.

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“…It is found that most investigators use alcoholic extraction as their initial crude extraction method [14]. Li et al [15] used methanol to obtain their first crude extract and then proceeded with further fractionation.…”

Section: Preparation Of Botanical Samples For Initial Screening Testsmentioning

confidence: 99%

“…This is often used after the initial crude extract is obtained [16,40]. A typical example is the work by Jutiviboonsuk et al [14], where the crude methanol extract was extracted again with petroleum ether to remove the fatty constituents, followed by partitioning with chloroform. This liquid phase extracted fraction with bioactivity moved forward to a series of solid phase extractions, as shown in column chromatography, that led to the isolation and purification of the bioactive molecules.…”

Section: Identification Of Active Molecules In Botanical Samples -Is mentioning

confidence: 99%

Preparation of Botanical Samples for Biomedical Research

Liu

2008

EMIDDT

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Plants are chemical storehouses, a fact which has driven countless multidisciplinary quests for bioactive compounds. As the very first step of botanical research, the whole desire is to find "hit" plants with specific bioactivities. It is logical to use some strategies that can maximize the chances of finding these "hits" with limited time and resources. In addition to selecting the right plants for screening, how the plant extracts are prepared can also influence the bioactivity screening outcomes. An extract from the same plant material can be quite different in chemical composition having different preparations. Because of the complex mixture nature of plant extracts, it is possible artifact activities may be observed. Thus confirmatory activity tests are often necessary to warrant the next laborious isolation step. A bioassay directed isolation approach may be the most efficient in identifying the bioactive compounds because of the narrowed focus at each isolation step, but a phytochemistry isolation approach is appropriate to characterize a purified bioactive extract. In fact, these two approaches can be taken intermittently whenever efficiency can be improved. Finally, use of the identified active compounds is now broader. In addition to determining a lead compound to continue a drug development path, there is an increasing interest in support for the use of botanical extracts as botanical drugs. Instead of dropping the extract after extracting the lead compound, the natural analogues representing the purified extract now have a chance to become leading compounds in the pursuit of novel therapies for metabolic syndrome and other diseases.

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Bioactive constituents from roots of Bursera tonkinensis

Cited by 111 publications

References 31 publications

Phenolic Compounds from Selaginella moellendorfii

Phenolic Compounds from Selaginella moellendorfii

Inhibitory effects of phenolic compounds from needles of Pinus densiflora on nitric oxide and PGE2 production

Preparation of Botanical Samples for Biomedical Research

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