Bioactive Constituents fromBoswelliapapyrifera

Abstract

Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.

Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphis barteri, Mitragyna inermis and Pseudocedrela kotschyi

“…Interpretation of 1D proton (400 MHz), HSQC and HMBC spectra (Bruker Avance 400, CD 3 OD) indicated that approximately equimolar amounts of 3-O-methyl-(E)-and 3-O-methyl-(Z)-resveratrol 5-Orutinosides were present. The former isomer has been reported from Elephantorrhiza goetzei (Leguminosae) (Wanjala and Majinda, 2001) and Boswellia papyrifera (Burseraceae) (Atta-ur-Rahman et al, 2005). A reexamination of the original crude extract with positive ion APCI-MS revealed an ion peak (m/z 243.1, [M+H] + ) that corresponds to 3-O-methylresveratrol (or its isomer), in addition to the two glycosides.…”

Synthesis of glycosides of resveratrol, pterostilbene, and piceatannol, and their anti-oxidant, anti-allergic, and neuroprotective activities

“…Recently, the inhibitory action of stilbene glycosides with glucosyl residue at their 3-position toward PDE has been reported. 35) This is the first description of the inhibition of PDE by the stilbene glycoside which has glucosyl residue at its 4′-position.…”

Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties

“…(found in East Africa), another deciduous, gum-producing, multipurpose perennial tree that grows in Somalia, Ethiopia, Eritrea, Sudan and in the other east African countries, is claimed to have been the source of olibanum in antiquity and produces resin of a quality known as “boido” [4,7,18]. …”

“…Meanwhile, it is also used in the treatment of amenorrhea, menorrhagia, polyuria, scrofula, syphilis, asthma, bronchitis, sores, and diseases of the nervous system [7]. Generally speaking, frankincense is widely used as an anti-inflammatory drug and numerous reports suggest that triterpenoids may be the bioactive ingredients responsible for these properties [6,8].…”