Bioactive compounds from herbal medicines to manage dyslipidemia

Ji, Xinyu; Shi, Shuai; Liu, Bin; Shan, Mingxu; Tang, Danli; Zhang, Wantong; Zhang, Yin; Zhang, Lulu; Zhang, Huamin; Lü, Cheng; Wang, Yongyan

doi:10.1016/j.biopha.2019.109338

Cited by 66 publications

(48 citation statements)

References 127 publications

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“…Dyslipidemia is a key risk factor in the development of cardiovascular diseases which leads to increased morbidity and mortality [ 8 ]. Natural products have been used as an alternative medicine for the prevention and management of cardiovascular diseases [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, natural products have been reported to have the potential to be developed faster and cheaper than conventional single drug. For example, curcumin, lycopene, monascin, ankaflavin, oleanolic acid, ursolic acid, berberine, amphene, tanshinone IIA, hesperetin, and naringenin inhibit cholesterol absorption in enterocytes [ 8 ]. Thus, natural products, especially phenolic compounds of these products, may inhibit pancreatic lipase, cholesterol esterase, and solubility of cholesterol micelles.…”

Section: Introductionmentioning

confidence: 99%

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Phenolic Profile of Nipa Palm Vinegar and Evaluation of Its Antilipidemic Activities

Chatatikun

Kwanhian

2020

Evidence-Based Complementary and Alternative Medicine

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Obesity and overweight are strongly associated with dyslipidemia which can promote the development of cardiovascular diseases. Recently, natural products have been suggested as alternative compounds for antioxidant and antilipidemic activity. The objective of this study was to determine the phenolic compounds and assess the inhibitory activities on pancreatic lipase, cholesterol esterase, and cholesterol micellization of nipa palm vinegar (NPV). Total phenolic content was assessed and phenolic compounds were determined using the Folin–Ciocalteu assay and liquid chromatography-mass spectrometry (LC-MS), respectively. Pancreatic lipase and cholesterol esterase inhibitory activities of the NPV were measured using enzymatic colorimetric assays. The formation of cholesterol micelles was assessed using a cholesterol assay kit. The phenolic content of NPV was 167.10 ± 10.15 µg GAE/mL, and LC-MS analyses indicated the presence of gallic acid, isoquercetin, quercetin, catechin, and rutin as bioactive compounds. Additionally, the NPV inhibited pancreatic lipase and cholesterol esterase activities in a concentration-dependent manner. Moreover, the NPV also suppressed the formation of cholesterol micellization. These results suggest that phenolic compounds, especially gallic acid, isoquercetin, quercetin, catechin, and rutin, from NPV may be the main active compounds with possible cholesterol-lowering effects through inhibition of pancreatic lipase and cholesterol esterase activities as well as the inhibition of solubility of cholesterol micelles. Therefore, NPV may delay postprandial dyslipidemia, and it could be used as a natural source of bioactive compounds with antilipidemic activity. However, NPV should be extensively evaluated by animal and clinical human studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolic Profile of Nipa Palm Vinegar and Evaluation of Its Antilipidemic Activities

Chatatikun

Kwanhian

2020

Evidence-Based Complementary and Alternative Medicine

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“…Gypenosides (extracted from Gynostemma pentaphyllum) (Li et al, 2017a), palmatine and jatrorrhizine (extracted from Coptidis Rhizoma) promote bile acid synthesis to prevent NAFLD, which involved the expression of cholesterol 7ahydroxylase A1 (CYP7A1). Punicalagin and pomegranate ellagic acid (isolated from Punica granatum L.) activate the CYP7A1/PPARg signaling to promote hepatic diversion of cholesterol into bile acid (Ji et al, 2019). Celastrus orbiculatus Thunb.…”

Section: Bile Acid Synthesis Involves In Herbal Medicine Modulation Omentioning

confidence: 99%

Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application

Guo

Zhang

et al. 2020

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with high prevalence in the developed countries. NAFLD has been considered as one of the leading causes of cryptogenic cirrhosis and chronic liver disease. The individuals with obesity, insulin resistance and diabetes mellitus, hyperlipidaemia, and hypertension cardiovascular disease have a high risk to develop NAFLD. The related critical pathological events are associated with the development of NAFLD including insulin resistance, lipid metabolism dysfunction, oxidative stress, inflammation, apoptosis, and fibrosis. The development of NAFLD range from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic steatosis is characterized by fat accumulation, which represents the early stage of NAFLD. Then, inflammation triggered by steatosis drives early NAFLD progression into NASH. Therefore, the amelioration of steatosis and inflammation is essential for NAFLD therapy. The herbal medicine have taken great effects on the improvement of steatosis and inflammation for treating NAFLD. It has been found out that these effects involved the multiple mechanisms underlying lipid metabolism and inflammation. In this review, we pay particular attention on herbal medicine treatment and make summary about the research of herbal medicine, including herb formula, herb extract and naturals compound on NAFLD. We make details about their protective effects, the mechanism of action involved in the amelioration steatosis and inflammation for NAFLD therapy as well as the clinical application.

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“…A number of natural and drug compounds have gained attention due to their favourable effects in insulin resistance, [141] anti-ageing, [142][143][144] muscle atrophy [145,146] and hyperlipidaemia. [147,148] For example, previous review showed that natural products, such as Zengye Decoction, Seyoeum, Wu-Mei-Wan, Erchen Decoction, Linguizhugan Decoction, Fenugreek seed, mulberry leaf and Jinlida, could improve insulin resistance in vitro or in vivo. [141] In the preclinical stage of pharmaceutical development, the C2C12 myoblast cell line enables the establishment of the potential safety profile and effective dosage range prior to testing of therapeutic agents in vivo by using animal models.…”

Section: Role Of Rosmentioning

confidence: 99%

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

Wong

Al‐Salami

Dass

2020

Journal of Pharmacy and Pharmacology

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Objectives The myoblast cell line, C2C12, has been utilised extensively in vitro as an examination model in understanding metabolic disease progression. Although it is indispensable in both preclinical and pharmaceutical research, a comprehensive review of its use in the investigation of insulin resistance progression and pharmaceutical development is not available. Key findings C2C12 is a well-documented model, which can facilitate our understanding in glucose metabolism, insulin signalling mechanism, insulin resistance, oxidative stress, reactive oxygen species and glucose transporters at cellular and molecular levels. With the aid of the C2C12 model, recent studies revealed that insulin resistance has close relationship with various metabolic diseases in terms of disease progression, pathogenesis and therapeutic management. A holistic, safe and effective disease management is highly of interest. Therefore, significant efforts have been paid to explore novel drug compounds and natural herbs that can elicit therapeutic effects in the targeted sites at both cellular (e.g. mitochondria, glucose transporter) and molecular level (e.g. genes, signalling pathway). Summary The use of C2C12 myoblast cell line is meaningful in pharmaceutical and biomedical research due to their expression of GLUT-4 and other features that are representative to human skeletal muscle cells. With the use of the C2C12 cell model, the impact of drug delivery systems (nanoparticles and quantum dots) on skeletal muscle, as well as the relationship between exercise, pancreatic b-cells and endothelial cells, was discovered. Applications and role of C2C12 skeletal muscle Chun Y. Wong et al.

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Bioactive compounds from herbal medicines to manage dyslipidemia

Cited by 66 publications

References 127 publications

Phenolic Profile of Nipa Palm Vinegar and Evaluation of Its Antilipidemic Activities

Phenolic Profile of Nipa Palm Vinegar and Evaluation of Its Antilipidemic Activities

Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

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