Bioaccumulation and damaging action of polymetal industrial dust on laboratory mice Mus musculus alba II. Genetic, cell, and metabolic disturbances

Protective Role of Omega-3 Polyunsaturated Fatty Acid against Lead Acetate-Induced Toxicity in Liver and Kidney of Female Rats

“…On the other hand, WBCs count of lead acetate treated rats was elevated compared to the negative control group, and these results are in agreement with those described by Kim et al [41] and Simsek et al [42]. However, Topashka-Ancheva et al [43] showed that lead could damage the erythrocytes membrane resulting in hemolysis or decrease of blood iron level which may be the reason of decreasing the concentration of Hb and PCV. These hematological alterations might be also due to the effect of lead on the activity of δ -aminolevulinic acid dehydrogenase which acts as key enzyme of heme synthesis.…”

Spirulina platensis feeding inhibited the anemia- and leucopenia-induced lead and cadmium in rats

“…Cd and Pb cause damage to the erythrocyte membrane resulting in hemolysis or a decrease of blood iron level which may be the cause of decreased concentration of haemoglobine and hematocrit value [5]. The decrease in ANAE + lymphocyte, RBC, and WBC counts, MCHC, Hb and PCV of Cd-and Pb-added groups was observed at the end of the study (p < 0.05).…”

“…The decrease in ANAE + lymphocyte, RBC, and WBC counts, MCHC, Hb and PCV of Cd-and Pb-added groups was observed at the end of the study (p < 0.05). Chronic oral cadmium and lead administration cause the development of hypochromic anemia and hemolytic anemia, respectively [5]. Reticulocytes were quitely increased in the Pb group compared to control group, but were decreased in Cd group (p < 0.05).…”

“…Furthermore, the anemia and eosinophilia associated with Cd toxicity have been largely studied in Itai-itai syndrome [1,4]. The acute and chronic lead poisoning also causes pathophysiological changes in tissues, and morphological changes in bone marrow cells, and necrosis in proximal tubular cells, reduces glomerular filtration rate and dysfunction in kidney [5], reduces semen quality, decreases sperm count and motility in the reproductive systems [6]. Lead toxicity induces changes in the composition of red blood cell (RBC) membrane proteins and lipids that inhibit haemoglobine synthesis, insufficient erythrocyte production, and reduce red cell survival [5].…”

Effectiveness Protection of Soy Flour and Spirulina on Lead Toxicity

“…Lead is heavy metal which has toxic effect for living beings even in a very low amount, electrical power sources and is used frequently in dye, plastic and fertilizer industry (Jensen et al, 2001). Lead (Pb) causes damage to the erythrocyte membrane resulting in hemolysis or a decrease of blood Fe level which might be decrease concentration of hemoglobin and hematocrit value (Ancheva et al, 2003).…”